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In vivo techniques for assessment of insulin sensitivity and glucose metabolism

Margaret K Hahn

Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca

Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira

Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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glucose concentrations (i.e. euglycemia); this requires frequent blood sampling and measuring of plasma glucose ( Fig. 1B , which is based on ( DeFronzo et al. 1979 , Pereira et al. 2013 )). A rat’s own red blood cells are reinfused i.v. throughout