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J Bryce Ortiz Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA

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Sebastian Tellez Arizona State University, School of Life Sciences, Tempe, Arizona, USA

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Giri Rampal Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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Grant S Mannino Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Nicole Couillard Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Matias Mendez Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Tabitha R F Green Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Sean M Murphy Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Rachel K Rowe Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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development, remains unclear. GH release is regulated by the hypothalamic peptides somatostatin and growth hormone releasing hormone (GHRH). Somatostatin is released from somatostatin-expressing neurons in the periventricular nucleus of the hypothalamus

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0157
Volume/Issue:
Volume 260: Issue 1
Open access
Rui Gao Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Samuel Acreman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden

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Jinfang Ma Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Fernando Abdulkader Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Anna Wendt Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden

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Quan Zhang Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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removed. This mixed effect on α-cell membrane potential was also observed in the presence of high glucose and hyperpolarisation could be reversed by blocking somatostatin receptors ( Zhang et al. 2013 ). As such, sulphonylureas could inhibit glucagon

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0295
Volume/Issue:
Volume 258: Issue 2
Open access
A Edlund Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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M Barghouth Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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M Hühn Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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M Abels Unit of Neuroendocrine Cell biology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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J S E Esguerra Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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I G Mollet Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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E Svedin Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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A Wendt Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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E Renström Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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E Zhang Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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N Wierup Unit of Neuroendocrine Cell biology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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B J Scholte Department of Cell Biology, Erasmus MC, Rotterdam, the Netherlands
Pediatric Pulmonology, Erasmus MC, Rotterdam, the Netherlands

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M Flodström-Tullberg Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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L Eliasson Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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F508del beta cells have defective exocytosis and insulin secretion. Finally, we measured islet glucagon and somatostatin secretion. The data presented highlight the important contribution of CFTR in beta cells for functional insulin secretion

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0570
Volume/Issue:
Volume 241: Issue 1
Open access
David Cottet-Dumoulin Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Quentin Perrier Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Vanessa Lavallard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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David Matthey-Doret Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Laura Mar Fonseca Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Juliette Bignard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Reine Hanna Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Géraldine Parnaud Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Fanny Lebreton Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Kevin Bellofatto Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Ekaterine Berishvili Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Thierry Berney Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Domenico Bosco Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Introduction Islets of Langerhans are the regions of the pancreas that contain endocrine cells. They are composed of four major cell types: alpha, beta, delta and pancreatic polypeptide (PP) cells, which secrete glucagon, insulin, somatostatin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0304
Volume/Issue:
Volume 258: Issue 2
Open access
Maria L Price Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Cameron D Ley Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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overexpressing SSTR5 and GHSR1a TR-FRET in INS-1 cells GHSR1a-SSTR5 heteromers impair somatostatin responsiveness in favour of ghrelin responses. However, more recent studies have shown that GHSR1a is not expressed in pancreatic β-cells and it is unlikely the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0206
Volume/Issue:
Volume 252: Issue 1
Open access
Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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glucagon deficiency secondary to total pancreatectomy ( Boden et al. 1980 ) and acute glucagon deficiency due to somatostatin infusion ( Boden et al. 1984 ) are also associated with elevated levels of plasma amino acids. Although the species of amino

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0365
Volume/Issue:
Volume 261: Issue 3
Open access
Michael Merkhassine Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
VCA Colonial Animal Hospital, Ithaca, New York, USA

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Reilly W Coch Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Weill Cornell College of Medicine, New York, New York, USA

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Carol E Frederick Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Lucinda L Bennett Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Seth A Peng Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Fate Therapeutics, San Diego, California, USA

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Benjamin Morse Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Bethany P Cummings Center for Alimentary and Metabolic Science, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, California, USA
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA

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John P Loftus Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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techniques, where combinations of insulin, glucose, or somatostatin are administered to control for hyperglycemia or isolate the role of glucagon in hepatic glucose production ( Shulman et al. 1978 ). A study isolating the effects of severe

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0051
Volume/Issue:
Volume 262: Issue 2
Open access
Nadia Schoenmakers University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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Kyriaki S Alatzoglou University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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V Krishna Chatterjee University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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Mehul T Dattani University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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the neuropeptides TRH, thyrotropin-releasing hormone; GHRH, growth-hormone releasing hormone; SST, somatostatin; CRH, corticotropin-releasing hormone ( Shimogori et al . 2010 , Diaz et al . 2015 ). In the developing rat, hypothalamus Trh cells first

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0341
Volume/Issue:
Volume 227: Issue 3
Open access
Kristen R Lednovich Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sophie Gough Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Medha Priyadarshini Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Nupur Pandya Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Chioma Nnyamah Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Kai Xu Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Barton Wicksteed Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sidharth Mishra USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Shalini Jain USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Joseph L Zapater Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Hariom Yadav USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Brian T Layden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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, including cholecystokinin, leptin, somatostatin, and ghrelin ( Hajishafiee et al. 2019 , Kumar & Singh2020 ). While we did observe a modest improvement in glucose homeostasis in the WD-fed Vil-FFA2 mice, it is unclear if this effect is due to changes in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0184
Volume/Issue:
Volume 260: Issue 2
Open access
Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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somatostatin infusions start at 0 h and the pancreatic euglycemic clamp usually lasts 2 h. Typical insulin and glucose concentrations are also shown. Created with BioRender.com. Glucose tracer methodology can be combined with the clamp and the glucose

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0308
Volume/Issue:
Volume 260: Issue 3
Open access