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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz and Kelly D McCall

). Specifically, NAFLD is a disease of excess fat accumulation in the liver of individuals with no history of alcohol abuse, which can range from benign steatosis to advanced steatohepatitis (NASH) and cirrhosis ( El-Serag & Kanwal 2014 ). NASH is associated with

Open access

Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker and Ruth Andrew

αR2) develop obesity and insulin resistance, with increased susceptibility to liver steatosis, fibrosis and hepatocellular carcinoma ( Dowman et al. 2013 , Livingstone et al. 2015 ). These findings translate into humans, where dutasteride (a dual

Open access

Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu and Pann-Ghill Suh

accumulation of neutral lipids, mainly triglycerides (TGs), without ethanol consumption, viral infection, or other etiologies. NAFLD ranged from simple steatosis to cirrhosis accompanied by oxidative stress and hepatic injury ( Angulo 2002 ). Although the

Open access

T Mracek, D Gao, T Tzanavari, Y Bao, X Xiao, C Stocker, P Trayhurn and C Bing

epididymal (C and D) fat. Data are means± s.e.m. for groups of 6. * P <0.05, *** P <0.001 compared with lean controls. ZAG gene and protein expression in liver of ob/ob mice Liver histology revealed the typical features of steatosis (fatty liver) in ob

Open access

Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovscki, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan and Assaf Rudich

, resulted in decreased hepatic steatosis, insulin resistance and glucose overproduction ( Sabio et al . 2008 , Wueest et al . 2010 , Zhang et al . 2011 ). Compared to this wealth of studies implicating adipose tissue inflammation in the pathogenesis

Open access

Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby and Margit Mahlapuu

steatosis) in the development of type 2 diabetes, atherosclerosis, acute pancreatitis and pancreatic cancer ( Catanzaro et al. 2016 ). In spite of this high medical relevance and an estimated prevalence between 16 and 35% ( Wang et al. 2014 , Lesmana

Open access

Jarrad M Scarlett, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant and Daniel L Marks

pronounced liver steatosis, we did not observe liver steatosis in the Band-AGRP rats. In summary, our data suggest that the central melanocortin system, a neural integrator of hormone and cytokine signaling that regulates feeding behavior, linear growth, and

Open access

S J Brandt, M Kleinert, M H Tschöp and T D Müller

liraglutide alone and also improves lipid metabolism and hepatic steatosis ( Choi et al. 2017 , Kim et al. 2017 ). A third example, Syn-GIP-ZP, is a triple agonist created by fusing a GLP-1R/GCGR dual agonist and a GIP analog to the heavy and light

Open access

Alvaro Souto Padron, Ruy Andrade Louzada Neto, Thiago Urgal Pantaleão, Maria Carolina de Souza dos Santos, Renata Lopes Araujo, Bruno Moulin de Andrade, Monique da Silva Leandro, João Pedro Saar Werneck de Castro, Andrea Claudia Freitas Ferreira and Denise Pires de Carvalho

therapeutic tool to overcome liver steatosis and insulin resistance; hence, it is tempting to speculate as to whether its chronic administration could lead to thyroid dysfunction, thus affecting other organs that do not respond to 3,5-T2. In this study, we

Open access

Gulizar Issa Ameen and Silvia Mora

-Vieira et al . 2014 ) or pharmacologic elevation of serum RBP4 causes insulin resistance and hepatic steatosis in mice ( Lee et al . 2016 ). Recent studies in transgenic mice models overexpressing Rbp4 gene in adipose tissue have revealed that RBP4 causes