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Open access

Jin Yu, Yuhuan Liu, Danying Zhang, Dongxia Zhai, Linyi Song, Zailong Cai, and Chaoqin Yu

deletion analysis and transcription factor-binding site analysis, GATA-binding factor 1 (GATA1) was identified as a transcription factor most relevant to the HSD3B2 gene expression after cells were incubated with baicalin. To further confirm these results

Open access

Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

) ( Garcia et al . 2014 ). Alternatively, as normal pituitary development depends on the sequential temporal and spatial expression of a cascade of signaling molecules and transcription factors, mutations in early ( HESX1, LHX3, LHX4, SOX3, OTX2 ) or late

Open access

Lei Zhang, Carol Paddon, Mark D Lewis, Fiona Grennan-Jones, and Marian Ludgate

-Akt (1:1000, room temperature, 1 h, Santa Cruz); and anti phospho-SYK (Tyr 352, 1:5000, overnight, 4 °C, BD Biosciences, San Jose, CA, USA). To investigate transcription factors, rabbit antibodies to phospho-PPARγ (Ser 82, 1:1000 overnight, 4 °C, Upstate

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby

transcription factors in macrophages ( Tsatsanis et al . 2006 ). These data contrast with the reduced IRS1 and AKT phosphorylation observed in the transgenic mice ( Jamieson et al . 2011 ), which may have been the result of the reduced circulating insulin

Open access

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, and Neil A Hanley

give rise to the adult cell lineages, including β-cells ( Murtaugh 2007 ). Experiments manipulating genes in mice have discovered a multitude of transcription factors that regulate this transition ( Wilson et al . 2003 ). Within a subset of progenitors

Open access

Yanli Miao, Haojie Qin, Yi Zhong, Kai Huang, and Caijun Rao

asprosin mediated inhibition of adipose browning To uncover the underlying mechanism of the aforementioned observations, we explored whether Nrf2, a crucial antioxidant transcription factor, was involved in the process. Nrf2 is a transcription factor

Open access

Bettina Geidl-Flueck and Philipp A Gerber

hepatocytes. DNL contributes to the maintenance of glucose homeostasis. A healthy balance of hepatocyte and adipocyte DNL is essential for maintaining systemic insulin sensitivity ( Song et al. 2018 ). The master transcription factors sterol

Open access

Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, and Stanley Andrisse

level ( Berlanga et al. 2014 ). Nuclear transcription factors (Liver X receptor (LxRα), sterol regulatory element-binding protein 1c (SREBP1c), carbohydrate-responsive element-binding protein (ChREBP), and farnesoid X receptor (FxR) and enzymes ACC1

Open access

Nan Yang, Giorgio Caratti, Louise M Ince, Toryn M Poolman, Peter J Trebble, Cathy M Holt, David W Ray, and Laura C Matthews

synthetic Gc molecules modulate the activity of the near ubiquitously expressed glucocorticoid receptor (GR). The GR is a member of the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor by interacting with chromatin to

Open access

Bernadette M Trojanowski, Heba H Salem, Heike Neubauer, Eric Simon, Martin Wagner, Rajkumar Dorajoo, Bernhard O Boehm, Leticia Labriola, Thomas Wirth, and Bernd Baumann

might determine disease onset and clinical progression in MODY patients. Mutations in the PDX1 gene account for the well-characterized MODY4 subtype ( Stoffers et al. 1997 , Ahlgren et al. 1998 ). PDX1 is a transcription factor critically involved