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deletion analysis and transcription factor-binding site analysis, GATA-binding factor 1 (GATA1) was identified as a transcription factor most relevant to the HSD3B2 gene expression after cells were incubated with baicalin. To further confirm these results

) ( Garcia et al . 2014 ). Alternatively, as normal pituitary development depends on the sequential temporal and spatial expression of a cascade of signaling molecules and transcription factors, mutations in early ( HESX1, LHX3, LHX4, SOX3, OTX2 ) or late

-Akt (1:1000, room temperature, 1 h, Santa Cruz); and anti phospho-SYK (Tyr 352, 1:5000, overnight, 4 °C, BD Biosciences, San Jose, CA, USA). To investigate transcription factors, rabbit antibodies to phospho-PPARγ (Ser 82, 1:1000 overnight, 4 °C, Upstate

transcription factors in macrophages ( Tsatsanis et al . 2006 ). These data contrast with the reduced IRS1 and AKT phosphorylation observed in the transgenic mice ( Jamieson et al . 2011 ), which may have been the result of the reduced circulating insulin

give rise to the adult cell lineages, including β-cells ( Murtaugh 2007 ). Experiments manipulating genes in mice have discovered a multitude of transcription factors that regulate this transition ( Wilson et al . 2003 ). Within a subset of progenitors

asprosin mediated inhibition of adipose browning To uncover the underlying mechanism of the aforementioned observations, we explored whether Nrf2, a crucial antioxidant transcription factor, was involved in the process. Nrf2 is a transcription factor

hepatocytes. DNL contributes to the maintenance of glucose homeostasis. A healthy balance of hepatocyte and adipocyte DNL is essential for maintaining systemic insulin sensitivity ( Song et al. 2018 ). The master transcription factors sterol

level ( Berlanga et al. 2014 ). Nuclear transcription factors (Liver X receptor (LxRα), sterol regulatory element-binding protein 1c (SREBP1c), carbohydrate-responsive element-binding protein (ChREBP), and farnesoid X receptor (FxR) and enzymes ACC1

synthetic Gc molecules modulate the activity of the near ubiquitously expressed glucocorticoid receptor (GR). The GR is a member of the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor by interacting with chromatin to

might determine disease onset and clinical progression in MODY patients. Mutations in the PDX1 gene account for the well-characterized MODY4 subtype ( Stoffers et al. 1997 , Ahlgren et al. 1998 ). PDX1 is a transcription factor critically involved