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Open access

Keld Fosgerau, Kirsten Raun, Cecilia Nilsson, Kirsten Dahl and Birgitte S Wulff

effective weight lowering drugs remains very relevant as complement to existing therapies ( Nguyen et al . 2012 ). Insulin-resistance plays a significant role in both obesity and prediabetes ( Reaven 1988 , Ferrannini 1993 ) and the reversal of the insulin

Open access

Xuefeng Yang, Shuang Mei, Haihua Gu, Huailan Guo, Longying Zha, Junwei Cai, Xuefeng Li, Zhenqi Liu and Wenhong Cao

) respond to acute insulin challenge much better than the diabetic animals treated with insulin, suggesting that hyperglycemia itself does not cause insulin resistance but treatment of T1DM with insulin does ( Liu et al . 2009 a ). In the absence of insulin

Open access

Sandra Pereira, Wen Qin Yu, María E Frigolet, Jacqueline L Beaudry, Yaniv Shpilberg, Edward Park, Cristina Dirlea, B L Grégoire Nyomba, Michael C Riddell, I George Fantus and Adria Giacca

Introduction Obesity leads to type 2 diabetes mellitus (T2DM) because of insulin resistance, and insulin resistance of obesity is due to elevated circulating levels of free fatty acids (FFAs) and cytokines ( Boden 1997 , Lewis et al . 2002

Open access

Corinne Caillaud, Mie Mechta, Heidi Ainge, Andreas N Madsen, Patricia Ruell, Emilie Mas, Catherine Bisbal, Jacques Mercier, Stephen Twigg, Trevor A Mori, David Simar and Romain Barrès

al . 2013 ). In this study, we investigated the effect of both acute and chronic EPO treatment on whole-body glucose metabolism and activation of the insulin signaling pathway in skeletal muscle. We found that EPO ameliorates diet-induced glucose

Open access

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu and E W Kraegen

resistance To establish whether the APPL1-mediated increase in muscle glycogen storage would be associated with acute increases in insulin-stimulated glucose uptake and glycogen synthesis, rats were subjected to a HEC combined with administration of

Open access

Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker and Ruth Andrew

αR2) develop obesity and insulin resistance, with increased susceptibility to liver steatosis, fibrosis and hepatocellular carcinoma ( Dowman et al. 2013 , Livingstone et al. 2015 ). These findings translate into humans, where dutasteride (a dual

Open access

Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker and Simon W Jones

implications for the treatment of metabolic diseases such as type 2 diabetes ( Bluher 2014 , Bluher & Mantzoros 2015 ). It has long been established that the accumulation of abdominal fat (central adiposity) is associated with insulin resistance ( Pratley et

Open access

Mark E Cleasby, Pauline M Jamieson and Philip J Atherton

, of which the significant majority would be of >40 years old ( IDF 2013 ). Of these, 90% suffer from type 2 diabetes (T2D), which is characterised by both β-cell failure and resistance to the actions of insulin at the tissue level (insulin resistance

Open access

Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovscki, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan and Assaf Rudich

inflammation (particularly macrophage infiltration) characterizes obese persons who develop insulin resistance ( Harman-Boehm et al . 2007 ), but to a much lesser degree age, sex and BMI-matched obese persons who remain insulin sensitive ( Kloting et al

Open access

Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby and Margit Mahlapuu

Introduction Type 2 diabetes, characterised by hyperglycaemia in the context of insulin resistance, is one of the most common metabolic diseases in the world. Insulin production from pancreatic β-cells plays a vital role in maintaining the