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Alessandro Pocai

insulin. Recent work on understanding the physiological function of proglucagon-derived peptides has renewed interest in glucagon-based therapeutics. One of these peptides is glucagon-like peptide-1 (GLP1), which is secreted from the L cells of the

Open access

Eun Young Lee, Shuji Kaneko, Promsuk Jutabha, Xilin Zhang, Susumu Seino, Takahito Jomori, Naohiko Anzai, and Takashi Miki

Introduction Oral ingestion of nutrients triggers the secretion of gut hormones from various enteroendocrine cells ( Ezcurra et al . 2013 , Cho et al . 2014 ). Among these, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic

Open access

Alyce M Martin, Emily W Sun, and Damien J Keating

-like peptide 1 (GLP-1), peptide YY (PYY) and oxyntomodulin (OXM), and glucose-dependent insulinotropic peptide (GIP) secreting K cells. It is now clear that such a classification system is not accurate given the accumulation of evidence that cross-over in

Open access

S J Brandt, M Kleinert, M H Tschöp, and T D Müller

). For example, following Roux-en-Y gastric bypass, gastric banding or sleeve gastronomy, there is an increase in the secretion of glucagon-like peptide 1 (GLP-1) ( Laferrere 2016 , Meek et al. 2016 , Clemmensen et al. 2017 ), which is known not

Open access

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

test (ITT), and measurement of GIP and GLP-1 content in intestine were evaluated in the second cohort. Energy expenditure, food intake, and gene expression were evaluated in the third cohort. The mice were housed in an air-controlled 25°C room with a

Open access

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, and Masamitsu Nakazato

placed in individual cages and allowed to recover for at least 7 days, during which they were handled daily for acclimation. Ghrelin (human), LEAP2 (human), des-acyl ghrelin (rat), NPY, and GLP-1 were purchased from Peptide Institute (Osaka, Japan). [D

Open access

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, and Neil A Hanley

al . 2003 ). Rab3a and Rab27a knockout mice show defects in glucose-stimulated insulin secretion (GSIS) similar to those observed in patients with type 2 diabetes and in mice lacking the glucagon-like peptide-1 (GLP-1) receptor ( Scrocchi et al

Open access

Kevin J P Ryan, Zoe C T R Daniel, Lucinda J L Craggs, Tim Parr, and John M Brameld

)D), which is an inactive precursor form, and calcitriol or 1,25-dihydroxyvitamin D (1,25(OH) 2 D), which is the active form. Blood concentrations of calcidiol range between 30 and 50 nM (i.e. 3–5×10 −8  M; McLeod & Cooke 1989 ), whereas calcitriol is much

Open access

Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real, and Miguel López

glucagon-like peptide 1 (GLP-1) agonism ( Beiroa et al . 2014 ). To elucidate the contribution of hypothalamic AMPK activity on the browning of WAT by THs, we genetically activated AMPK in the VMH of rats centrally treated with T 3 . Our data showed that

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu, and Itaru Kojima

-sensing receptor in human GLP-1-secreting cells . Molecular and Cellular Endocrinology 394 70 – 79 . ( doi:10.1016/j.mce.2014.07.004 ) Oya M Suzuki H Watanabe Y Sato M Tsuboi T 2011 Amino acid taste receptor regulates insulin secretion in