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Open access

Corinne Caillaud, Mie Mechta, Heidi Ainge, Andreas N Madsen, Patricia Ruell, Emilie Mas, Catherine Bisbal, Jacques Mercier, Stephen Twigg, Trevor A Mori, David Simar and Romain Barrès

as a regulator involved in glucose metabolism. Results of early studies carried out of patients with end-stage renal disease (ESRD) indicated that EPO not only treated anemia but also improved insulin sensitivity ( Borissova et al . 1993 , Mak 1996

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu and Itaru Kojima

activated by glucose, and promotes metabolism of fuels in β-cells leading to an increase in ATP ( Nakagawa et al . 2014 ). Since knockdown of T1R3 attenuates glucose-induced elevation of intracellular ATP ([ATP] c ), the glucose-sensing receptor T1R3 is

Open access

Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker and Simon W Jones

insulin stimulation of glucose uptake in muscle cells . American Journal of Physiology. Endocrinology and Metabolism 280 E229 – E237 . ( ) 10.1152/ajpendo.2001.280.2.E229) Montessuit C Rosenblatt

Open access

Alyce M Martin, Emily W Sun and Damien J Keating

regulatory roles in glucose homeostasis, centrally-mediated appetite control and adiposity. This review focuses on the molecular mechanisms driving gut hormone secretion and describes how this is significant in the context of human metabolism and the

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson and Mark E Cleasby

of UCN3 in metabolism are less advanced. Injection of UCN3 into the VMH elevated blood glucose and insulin levels and reduced food intake ( Chen et al . 2010 ), while overexpression of UCN3 in the rostral perifornical area of the brain caused

Open access

Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker and Ruth Andrew

a recording frame (Linton Instruments, Diss, Norfolk, UK) overnight (14.5 h) and quantified using AMON software. Animals were re-housed in groups, after testing. One week later, mice underwent glucose tolerance testing (GTT: 2 g glucose/kg body

Open access

Gisela Helfer and Qing-Feng Wu

. 2007 ). Subsequent studies revealed that chemerin acts on its receptor CMKLR1 to affect adipogenesis, angiogenesis and inflammation in adipose tissue. Beyond the lipid metabolism, chemerin also influences the dysregulation of glucose metabolism

Open access

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu and E W Kraegen

characterised by lipid-induced impairments in glucose disposal, glycogen synthesis and lipid use in muscle and in the associated signalling pathways ( Hegarty et al . 2003 ). The identification of key molecular mediators of normal metabolism and obesity

Open access

S J Brandt, M Kleinert, M H Tschöp and T D Müller

diet-induced obesity ( Kim et al. 2012 ). Chronic GIPR agonism further improves glucose metabolism in DIO mice without signs of excess weight gain ( Martin et al. 2013 ). Transgenic pigs expressing a dominant negative GIP receptor in the pancreas

Open access

Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole and Jeremy W Tomlinson

decreased following dexamethasone treatment, indicative of decreased AKR1D1 activity (C). Data are presented as mean ±  s.e. of n  = 14 participants, *** P  < 0.001. AKR1D1 knockdown alters glucose metabolism gene expression through FXR, GR