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L Nicol
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M-O Faure MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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J R McNeilly
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J Fontaine MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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C Taragnat MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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A S McNeilly
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treatment groups. Values represent means± s.e.m. from one representative experiment; n =2. Effects of BMP-4 on the GnRH-induced activation of ERK1/2, p38 MAPK and CREB As there is evidence that, as well as signalling through the Smad pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0542
Volume/Issue:
Volume 196: Issue 3
Open access
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Nami Kim Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea
Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Jung Ok Lee Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Hye Jeong Lee Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Yong Woo Lee Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Hyung Ip Kim Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Su Jin Kim Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Sun Hwa Park Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Chul Su Lee Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Sun Woo Ryoo Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Geum-Sook Hwang Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea
Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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Hyeon Soo Kim Department of Anatomy, Department of Medicine, Integrated Metabolomics Research Group, Department of Life Science, Korea University College of Medicine, Seoul 136-701, South Korea

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uptake ( Niu et al . 2003 , Cheng et al . 2006 ). To understand the signaling pathways involved in isoeugenol-induced glucose uptake, we investigated the effects of isoeugenol on p38MAPK. Isoeugenol (10 μM) increased p38MAPK phosphorylation in a time

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0302
Volume/Issue:
Volume 228: Issue 2
Open access
Sandra Pereira Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Wen Qin Yu Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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María E Frigolet Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Jacqueline L Beaudry Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Yaniv Shpilberg Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Edward Park Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Cristina Dirlea Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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B L Grégoire Nyomba Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Michael C Riddell Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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I George Fantus Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Adria Giacca Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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through which IKKB induces insulin resistance are twofold: i) direct phosphorylation of insulin receptor substrate (IRS)-1 at serine 307 ( Gao et al . 2002 ), which impairs tyrosine phosphorylation of IRS-1 and therefore dampens the insulin signal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0214
Volume/Issue:
Volume 217: Issue 1
Open access
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Maayan Vatarescu The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Sapir Bechor The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Yulia Haim The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tal Pecht The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tanya Tarnovscki The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Noa Slutsky The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Ori Nov The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Hagit Shapiro The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Avishai Shemesh The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Angel Porgador The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Nava Bashan The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Assaf Rudich The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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-1369 ) Bluher M Bashan N Shai I Harman-Boehm I Tarnovscki T Avinaoch E Stumvoll M Dietrich A Kloting N Rudich A 2009 Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0007
Volume/Issue:
Volume 233: Issue 3
Open access
Ismael González-García Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Pablo B Martínez de Morentin Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Ánxela Estévez-Salguero Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Cristina Contreras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Amparo Romero-Picó Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Manuel Tena-Sempere Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Reina Sofía, Córdoba, Spain
FiDiPro Program, University of Turku, Turku, Finland

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Sulay Tovar Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Miguel López Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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for investigation. In this sense, the existence of membrane-initiated estrogen signaling effects in POMC neurons, involving for example mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) ( López & Tena

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0190
Volume/Issue:
Volume 238: Issue 3
Open access
Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

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Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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(MAPK), extracellular signal-regulated kinases (ERK) and phosphatidylinositol 3 kinase (PI3K)-AKT pathways to regulate biological functions such as angiogenesis and inflammation ( Wittamer et al . 2003 , Goralski et al . 2007 , Sell et al . 2009

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0174
Volume/Issue:
Volume 238: Issue 2
Open access
Andrea Mafficini ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy

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Aldo Scarpa ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy

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VHL Genetic syndrome (Von-Hippel Lindau) PI3K/mTOR NF1 Genetic syndrome (neurofibromatosis type I) PI3K/mTOR, Ras/MAPK TSC1/TSC2 Genetic syndrome (tuberous sclerosis) PI3K/mTOR PTEN Next-generation sequencing of PanNETs

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0560
Volume/Issue:
Volume 236: Issue 3
Open access
Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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of ligand-independent AR signalling has been described in prostate cancer where upregulation of androgen target genes occurs through pathways such as the protein kinase A (PKA), proteins kinase C and mitogen-activated protein kinases (MAPK) signalling

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0398
Volume/Issue:
Volume 261: Issue 3
Open access
Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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, there is now overwhelming evidence that seasonal changes in day length (photoperiod) provide the primary environmental cue for a diverse range of organisms. In contrast to all other environmental cues, photoperiod offers a highly predictive signal that

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0141
Volume/Issue:
Volume 222: Issue 2
Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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Olwin BB 2014 p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice . Nature Medicine 20 265 – 271 . ( doi:10.1038/nm.3465 ) Bodine SC Latres E Baumhueter S Lai VK Nunez

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
Open access