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T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll and L F Chan

Introduction Melanocortin receptor accessory protein (MRAP) and its paralogue MRAP2 are a recently identified class of small, single-pass transmembrane domain accessory proteins ( Chan et al . 2009 , Novoselova et al . 2013 ). Both MRAP and

Open access

K S Wilson, C S Tucker, E A S Al-Dujaili, M C Holmes, P W F Hadoke, C J Kenyon and M A Denvir

associated with melanocortin receptor accessory proteins (also expressed in head kidney). The activity of Mcr4 in larval fish is inhibited by Mrap2a (a larval MRAP paralog which inhibits Mcr4 actions) ( Sebag et al . 2013 ). As GCs have been shown to

Open access

R Prasad, J C Kowalczyk, E Meimaridou, H L Storr and L A Metherell

the adrenal, namely mutations in the ACTH receptor, melanocortin 2 receptor ( MC2R ), and its accessory protein MRAP (melanocortin receptor accessory protein) ( Clark et al . 1993 , Metherell et al . 2005 , Meimaridou et al . 2013 ). Novel

Open access

E Meimaridou, M Goldsworthy, V Chortis, E Fragouli, P A Foster, W Arlt, R Cox and L A Metherell

. 2009 , Rubtsov et al . 2009 , Sahakitrungruang et al . 2010 , 2011 , Parajes et al . 2011 ). In FGD, the two most common gene defects are mutations in the melanocortin 2 receptor and its accessory protein ( MC2R and MRAP ), but recently, we