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Recent advances in central congenital hypothyroidism

Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

-protein coupled receptor, TRHR, and activates a Gq/11 dependent pathway involving mobilization of intracellular calcium and activation of protein kinase C, culminating in TSH synthesis and secretion. Pyroglutamyl peptidase II (PPII) activity subsequently mediates