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Claes Ohlsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Petra Henning Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin H Nilsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Jianyao Wu Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Karin L Gustafsson Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Klara Sjögren Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Anna Törnqvist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Antti Koskela Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Fu-Ping Zhang Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Marie K Lagerquist Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Matti Poutanen Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland

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Juha Tuukkanen Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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Ulf H Lerner Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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Sofia Movérare-Skrtic Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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reported to affect all aspects of skeletal development, including craniofacial, limb and joint formation. In addition, mutations in several members of the WNT signaling pathways result in skeletal malformations in humans and mice ( Balemans et al . 2001

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0020
Volume/Issue:
Volume 237: Issue 2
Open access
Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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). The Wnt/β-catenin pathway plays a critical function at the site of implantation as inhibition of this signaling pathway interferes with the process ( Mohamed et al . 2005 ). Several WNT proteins (WNT4, WNT5A, WNT6, and WNT7A) are highly expressed in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0523
Volume/Issue:
Volume 229: Issue 2
Open access
Thomas Funck-Brentano Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Karin H Nilsson Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Robert Brommage Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Petra Henning Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ulf H Lerner Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Antti Koskela Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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Juha Tuukkanen Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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Martine Cohen-Solal BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France

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Sofia Movérare-Skrtic Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Claes Ohlsson Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Introduction WNT ligands belong to a family of 19 secreted cysteine-rich glycoproteins that are essential for development and tissue homeostasis ( Clevers & Nusse 2012 ). They signal through both the canonical WNT-β-catenin pathway and the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0153
Volume/Issue:
Volume 238: Issue 1
Open access
K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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control proximo–distal and anterior–posterior patterning in the growing limb bud. These two centres are regulated by signalling pathways such as Indian hedgehog (IHH) and WNT/β-catenin (reviewed elsewhere; Summerbell et al . (1973) , Kronenberg (2003

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0276
Volume/Issue:
Volume 219: Issue 1
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Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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reduced ( Fig. 5 ), highlighting different impacts on protein stability and mRNA turnover. In addition, GTx-024 and Danazol both induced a significant reduction in the uterine expression of Wnt4 and Wnt7a , consistent with previously reported DHT

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0153
Volume/Issue:
Volume 242: Issue 3
Open access
Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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( Alonso & Ralston 2014 ). Such studies have identified the two key regulatory pathways – canonical Wnt signalling and receptor activator of nuclear factor kappa-B ligand (RANKL)/RANK/osteoprotegerin (OPG) that respectively regulate the function of

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Review Article
DOI:
https://doi.org/10.1530/JOE-16-0258
Volume/Issue:
Volume 231: Issue 1
Open access
Erica Yeo Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

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Patricia L Brubaker Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada

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Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada

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investigated these signaling pathways in the maternal L-cell during pregnancy, although genetic variants of TCF proteins (nuclear Wnt pathway components) have been associated with the development of GDM ( Shaat et al. 2007 , Reyes-López et al. 2014 ). But

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Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-21-0354
Volume/Issue:
Volume 253: Issue 1
Open access
Ashley Patton Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA

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Tyler Church Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Caroline Wilson Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA

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Jean Thuma Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Douglas J Goetz Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA

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Darlene E Berryman Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

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Edward O List Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

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Frank Schwartz Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Kelly D McCall Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA

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to the inflammation present in NAFLD ( Lu et al . 2008 , Broering et al . 2011 ). TLR4 signaling is mediated via two intracellular pathways involving the myeloid differentiation primary response 88 (MyD88) or adaptor proteins translocation

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Research Article
DOI:
https://doi.org/10.1530/JOE-18-0078
Volume/Issue:
Volume 237: Issue 3
Open access
Ryoko Yamamoto Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Tomoko Minamizaki Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Yuji Yoshiko Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Hirotaka Yoshioka Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Kazuo Tanne Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Jane E Aubin Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Norihiko Maeda Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Introduction Inorganic phosphate (Pi) contributes to multiple cell pathways and processes by acting as a component of mineralized matrices, nucleic acids and phospholipid bilayers; as a source of energy in the hydrolysis of ATP; as a substrate for

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0058
Volume/Issue:
Volume 206: Issue 3
Open access
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Jin-Ran Chen Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Oxana P Lazarenko Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Haijun Zhao Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Alexander W Alund Interdisciplinary Biomedical Sciences , University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Kartik Shankar Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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and to program gene expression in key metabolic pathways, such as fatty acids and glucose metabolism ( Levin & Govek 1998 , King 2006 , Shankar et al . 2008 , Geraghty et al . 2016 ). Emerging evidence suggests that maternal obesity caused by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0244
Volume/Issue:
Volume 239: Issue 1
Open access