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cerebral cortex and nucleus accumbens (NAc) ( Phillips et al. 2007 ). Recent studies have shown that mesolimbic dopamine neurons in the ventral tegmental area (VTA) that project to the NAc represent a critical site for ghrelin to trigger food consumption
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
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catecholamine neurotransmitter, dopamine, rather than the more typical peptide hypothalamic hormones involved in regulating all other pituitary systems. Prolactin is also the only anterior pituitary hormone that does not have an endocrine target tissue, and
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) Interactions with prostanoid receptors impair GHSR1a constitutive signalling. AGRP, agouti-related peptide; Ca 2+ i , intracellular Ca 2+ ; DRD1, dopamine receptor D1; DRD2, dopamine receptor D2; EP3-I, prostaglandin E 2 receptor subtype EP 3-I ; GHSR1, growth
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overactivation and progression of HF is less well known. Circulating catecholamines, comprising dopamine (DA), norepinephrine (NE) and epinephrine (EPI), are primarily synthesized and released from the chromaffin cells of the adrenal medulla ( Goldstein et al
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modulated by signals generated by neurotransmitter and hormone binding to G protein-coupled receptors (GPCR) present on islet β-cells ( Lang 1999 , Henquin 2000 , Ahren et al . 2006 ). Several GPCR agonists including norepinephrine, dopamine, galanin, and
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, but that not all immunohistochemically identified PRL cells are EYFP+ve ( Fig. 1 , panels A and B). In the essentially dopamine-free environment of primary cell culture for 5 days (120 000 cells in 2 ml DMEM containing 10% FCS), there was no evidence
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/activated Caspase-3 double positive cells, although the study did not determine whether these cells were lactotrophs ( Guillou et al. 2011 ). There is also evidence for redundancy in AL programmed cell death mechanisms as autocrine production of dopamine has been
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neurotransmitters such as acetylcholine ( Jing et al. 2018 ) and dopamine ( Patriarchi et al. 2018 ), one can hope that these tools will soon be suitable for in vivo detection of peptides and neuropeptides. Declaration of interest The authors declare
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circulating oestrogen might sensitize pituitary cells to pro-apoptotic signals such as lipopolysaccharide, FasL and dopamine ( Pisera et al . 2004 , Jaita et al . 2005 , Radl et al . 2008 ). Induction of apoptosis is frequently mediated through the Fas
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development . Neuroendocrinology 94 265 – 277 . ( https://doi.org/10.1159/000330857 ) Fontaine R Affaticati P Yamamoto K Jolly C Bureau C Baloche S Gonnet F Vernier P Dufour S Pasqualini C 2013 Dopamine inhibits reproduction in
