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Introduction The pituitary gland is a key regulator of body homeostasis and responsible for signal exchanges between the hypothalamus and peripheral organs. Besides of the six different endocrine cell types (e.g. corticotrophs
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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proportion to fat mass ( Das 2001 ). Other important endocrine factors that are susceptible to in utero programming and critical in determining adipose tissue function and later adiposity include the glucocorticoid receptor (GR or NR3C1 as listed in the
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Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic islet tumours ( Pieterman et al. 2009 , Goudet et al. 2010
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transcriptional signatures associated with proliferation, cell cycle progression, apoptotic evasion and other tumourigenic processes. Hence, endocrine therapy – aimed either at directly competing with estrogen for ER binding (e.g. tamoxifen) or at blocking
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The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Introduction Human epidemiological observations and experimental studies in animals have shown that the intrauterine environment has an important role in determining the adult metabolic and endocrine phenotype ( Hales & Barker 2001 , Gluckman
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in the community: a twenty-year follow-up of the Whickham Survey . Clinical Endocrinology 43 55 – 68 . Vassart G Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth . Endocrine Reviews 13 596
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, 2012 Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline . Journal of Clinical Endocrinology and Metabolism 97 2543 – 2565 . ( https://doi.org/10.1210/jc.2011-2803 ) Gu W Roeder
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Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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Endocrine Society 1 202 – 210 . ( https://doi.org/10.1210/js.2016-1094 ) Pemberton PA Stein PE Pepys MB Potter JM Carrell RW 1988 Hormone binding globulins undergo serpin conformational change in inflammation . Nature 336 257 – 258 . ( https
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EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK
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Introduction For almost a century, neuroendocrinologists have worked towards characterising the central regulation of endocrine axes that ensure critical functions such as reproduction, growth, and metabolism. While research questions have for
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Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
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population and are, by mass, the largest endocrine tissue in the body ( Ahlman & Nilsson 2001 ). EE cells consist of an array of different cell types, synthesising and secreting a combination of more than 20 hormones in response to a variety of luminal and