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Jane J Reavey MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Catherine Walker MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Alison A Murray MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Savita Brito-Mutunayagam MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Sheona Sweeney MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Moira Nicol MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Ana Cambursano MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Hilary O D Critchley MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Jacqueline A Maybin MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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women have no structural cause for their regular AUB and are assigned the AUB-E (AUB of endometrial origin) category. The cause of AUB-E remains undefined but current studies implicate excessive inflammation, delayed repair of the endometrium and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0446
Volume/Issue:
Volume 249: Issue 2
Open access
Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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epithelial cells surrounding the lumen and glands of the endometrium, as well as the smooth muscle cells of the myometrium ( Simitsidellis et al. 2018 ). Studies in women and rodents have demonstrated that secretions from endometrial glands play a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0153
Volume/Issue:
Volume 242: Issue 3
Open access
Yaxiong Huang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Zihan Wang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Bin Li Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Lina Ke Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Yao Xiong Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Yuanzhen Zhang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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EM, and they also experience a higher rate of pregnancy-related complications ( Breintoft et al. 2021 , Corachan et al. 2021 ). Recent studies have indicated that the nonreceptive endometrium plays a crucial role in infertility among EM patients

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0319
Volume/Issue:
Volume 261: Issue 2
Open access
Yoshihiro Joshua Ono Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Yoshito Terai Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Akiko Tanabe Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Atsushi Hayashi Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Masami Hayashi Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Yoshiki Yamashita Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Satoru Kyo Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Masahide Ohmichi Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan

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Introduction Endometriosis is a chronic, benign disease, which is characterized by the presence of endometrium-like tissue outside the uterine cavity, primarily on the ovaries. It is a major cause of symptoms such as pelvic pain, dysmenorrhea

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0393
Volume/Issue:
Volume 223: Issue 2
Open access
Graham W Aberdeen Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Jeffery S Babischkin Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Vascular endothelial growth factor mediates the estrogen-induced breakdown of tight junctions between and increase in proliferation of microvessel endothelial cells in the baboon endometrium . Endocrinology 149 6076 – 6083 . ( https://doi.org/10.1210/en

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0364
Volume/Issue:
Volume 262: Issue 1
Open access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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addition, sex steroid-sensitive epithelial cells in organs such as the prostate, breast, and endometrium are separated from blood capillaries by complex basement membranes, and are compartmentalized together with other cell types (e.g., stroma and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0070
Volume/Issue:
Volume 230: Issue 1
Open access
Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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documented in a range of tissues, including the prostate, adipose tissue and the endometrium ( Schiffer et al. 2018 , Simitsidellis et al. 2018 ). Notably, intracrine androgen action has been proposed to affect immune cell function and has been described

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0398
Volume/Issue:
Volume 261: Issue 3
Open access
Gulizar Issa Ameen Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Silvia Mora Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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studied. A recent study in heifers showed Rbp4 mRNA and protein levels raised in the endometrium during the dioestrus phase with elevated progesterone levels ( Mullen et al . 2012 ). This may be related to the role of retinoic acid signalling in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0359
Volume/Issue:
Volume 236: Issue 1
Open access
Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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the decidua and interface with the fetal placenta. All of the four genes studied exhibited an increase in transcript expression in response to progesterone alone. The expression of WNT5A protein in the endometrium was restricted to the epithelial cells

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0523
Volume/Issue:
Volume 229: Issue 2
Open access
Colin P Sibley Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
St Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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abnormal physiological conversion of the spiral arteries in the endometrium supplying blood to the intervillous (maternal) blood space (IVS) of the placenta ( Brosens et al . 2011 ). In normal pregnancy, following the formation of the placenta extravillous

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0185
Volume/Issue:
Volume 234: Issue 2
Open access