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Ying Sze
Ying Sze
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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Joana Fernandes
Joana Fernandes
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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Zofia M Kołodziejczyk
Zofia M Kołodziejczyk
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
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Paula J Brunton
Paula J Brunton
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China
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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China
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( Pariante & Lightman 2008 ). The HPA axis is the primary neuroendocrine stress response system. It is activated following perturbations to normal homeostasis, resulting in increased secretion of glucocorticoids from the adrenal gland, which mobilises energy
Huali Yu
Huali Yu
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Ye Guo
Ye Guo
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Yang Zhao
Yang Zhao
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Feng Zhou
Feng Zhou
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Kehan Zhao
Kehan Zhao
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Mayuqing Li
Mayuqing Li
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Junxiong Wen
Junxiong Wen
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Zixuan He
Zixuan He
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Xiaojuan Zhu
Xiaojuan Zhu
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Xiaoxiao He
Xiaoxiao He
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Introduction Glucocorticoids (GCs) have profound influences on many physiological functions, including growth, metabolism, development, behaviors and stress reactions ( Blodgett et al. 1956 , Munck et al. 1984 , Haskett 1985 ). They also
K S Wilson
K S Wilson
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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C S Tucker
C S Tucker
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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E A S Al-Dujaili
E A S Al-Dujaili
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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M C Holmes
M C Holmes
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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P W F Hadoke
P W F Hadoke
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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C J Kenyon
C J Kenyon
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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M A Denvir
M A Denvir
The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
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publications have highlighted the developmental aspects of altered embryonic glucocorticoid exposure in zebrafish ( Hillegass et al . 2008 , Pikulkaew et al . 2011 , De Marco et al . 2013 , Nesan & Vijayan 2013 , 2016 , Faught et al . 2016 ), few
Dawn E W Livingstone
Dawn E W Livingstone
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Emma M Di Rollo
Emma M Di Rollo
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Chenjing Yang
Chenjing Yang
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Lucy E Codrington
Lucy E Codrington
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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John A Mathews
John A Mathews
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Madina Kara
Madina Kara
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Katherine A Hughes
Katherine A Hughes
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Christopher J Kenyon
Christopher J Kenyon
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Brian R Walker
Brian R Walker
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Ruth Andrew
Ruth Andrew
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Introduction Activation of the hypothalamic–pituitary–adrenal (HPA) axis is a vital component of the stress response, driving production of glucocorticoid hormones (cortisol in humans, corticosterone in rodents) that mediate essential adaptations of
Jethro S Johnson
Jethro S Johnson
Computational Genomics Analysis and Training, Medical Research Council-Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
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Monica N Opiyo
Monica N Opiyo
University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK
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Marian Thomson
Marian Thomson
Edinburgh Genomics, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK
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Karim Gharbi
Karim Gharbi
Edinburgh Genomics, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK
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Jonathan R Seckl
Jonathan R Seckl
University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK
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Andreas Heger
Andreas Heger
Computational Genomics Analysis and Training, Medical Research Council-Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
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Karen E Chapman
Karen E Chapman
University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK
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) contributes to intracellular glucocorticoid action by catalysing the conversion of inactive to active forms of the principal glucocorticoids found in humans (cortisone to cortisol) and mice (11-dehydrocorticosterone to corticosterone). Whilst widely
Elisa Villalobos
Elisa Villalobos
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Allende Miguelez-Crespo
Allende Miguelez-Crespo
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Ruth A Morgan
Ruth A Morgan
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Scotland’s Rural College, The Roslin Institute, Easter Bush Campus, United Kingdom
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Scotland’s Rural College, The Roslin Institute, Easter Bush Campus, United Kingdom
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Lisa Ivatt
Lisa Ivatt
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Mhairi Paul
Mhairi Paul
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Joanna P Simpson
Joanna P Simpson
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Natalie Z M Homer
Natalie Z M Homer
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Dominic Kurian
Dominic Kurian
The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom
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Judit Aguilar
Judit Aguilar
The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom
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Rachel A Kline
Rachel A Kline
The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom
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Thomas M Wishart
Thomas M Wishart
The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom
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Nicholas M Morton
Nicholas M Morton
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Centre for Systems Health and Integrated Metabolic Research, Nottingham Trent University, Nottingham, United Kingdom
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Centre for Systems Health and Integrated Metabolic Research, Nottingham Trent University, Nottingham, United Kingdom
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Roland H Stimson
Roland H Stimson
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Ruth Andrew
Ruth Andrew
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Brian R Walker
Brian R Walker
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Mark Nixon
Mark Nixon
University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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Introduction Glucocorticoids are required to maintain glucose and lipid homeostasis in times of physiological stress, ensuring an adequate fuel supply for the body ( Kuo et al. 2015 ). In key metabolic tissues such as adipose tissue
Andrea Lovdel
Andrea Lovdel
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Karla J Suchacki
Karla J Suchacki
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Fiona Roberts
Fiona Roberts
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Richard J Sulston
Richard J Sulston
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Robert J Wallace
Robert J Wallace
Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK
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Benjamin J Thomas
Benjamin J Thomas
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Rachel M B Bell
Rachel M B Bell
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Iris Pruñonosa Cervera
Iris Pruñonosa Cervera
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Gavin J Macpherson
Gavin J Macpherson
Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
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Nicholas M Morton
Nicholas M Morton
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK
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Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK
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Natalie Z M Homer
Natalie Z M Homer
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Karen E Chapman
Karen E Chapman
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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William P Cawthorn
William P Cawthorn
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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) ( Bravenboer et al. 2020 , Cawthorn 2020 ). Bone marrow adipocytes further accumulate in diverse conditions, including ageing, obesity, type 2 diabetes, osteoporosis, chronic kidney disease, and in iatrogenic contexts such as chronic glucocorticoid treatment
Stuart A Morgan
Stuart A Morgan
Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK
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Department of Biosciences, Nottingham Trent University, Nottingham, UK
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Laura L Gathercole
Laura L Gathercole
Department of Biological & Medical Sciences, Oxford Brooks University, Oxford, UK
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Zaki K Hassan-Smith
Zaki K Hassan-Smith
Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
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Jeremy Tomlinson
Jeremy Tomlinson
Radcliffe Department of Medicine, University of Oxford, Oxford, UK
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Paul M Stewart
Paul M Stewart
Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
NEXUS, Discovery Way, University of Leeds, Leeds, UK
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NEXUS, Discovery Way, University of Leeds, Leeds, UK
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Gareth G Lavery
Gareth G Lavery
Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK
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Department of Biosciences, Nottingham Trent University, Nottingham, UK
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improve healthspan. Interestingly, the aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid (GC) excess (Cushing’s syndrome), including insulin resistance, type 2 diabetes mellitus, central obesity, hypertension
Geoffrey L Hammond
Geoffrey L Hammond
Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
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aldosterone, which is bound primarily by albumin, other steroid hormones bind to CBG and SHBG with high (nM) affinity and specificity, with SHBG binding the major androgens and estrogens, and CBG binding the glucocorticoids and progesterone, preferentially
A McMaster
A McMaster
Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular
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Medicine, Faculty of Life Sciences, Centre for Molecular
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T Chambers
T Chambers
Medicine, Faculty of Life Sciences, Centre for Molecular
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Q-J Meng
Q-J Meng
Medicine, Faculty of Life Sciences, Centre for Molecular
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S Grundy
S Grundy
Medicine, Faculty of Life Sciences, Centre for Molecular
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A S I Loudon
A S I Loudon
Medicine, Faculty of Life Sciences, Centre for Molecular
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R Donn
R Donn
Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular
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Medicine, Faculty of Life Sciences, Centre for Molecular
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D W Ray
D W Ray
Medicine, Faculty of Life Sciences, Centre for Molecular
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Introduction Glucocorticoid hormones exert a wide diversity of effects in target tissues. Their activity has been typically explored using a limited number of timed end points, both in vivo and in vitro , and using such approaches a variety of
