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Open access

Jethro S Johnson, Monica N Opiyo, Marian Thomson, Karim Gharbi, Jonathan R Seckl, Andreas Heger, and Karen E Chapman

is protective against the adverse metabolic and pro-inflammatory effects of a high-fat diet ( Morton et al . 2004 , Wamil et al . 2011 ) and improves insulin sensitivity/glucose homeostasis in models of type 2 diabetes ( Morton et al . 2004 ). 11β

Open access

Jane J Reavey, Catherine Walker, Alison A Murray, Savita Brito-Mutunayagam, Sheona Sweeney, Moira Nicol, Ana Cambursano, Hilary O D Critchley, and Jacqueline A Maybin

( Brasted et al. 2003 ) where mice were randomised to a high-fat or control diet for three months prior to menses induction. As a surrogate marker of MBL, endometrial repair was graded and compared in the two groups ( Kaitu’u-Lino et al. 2007 ). Current

Open access

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

glucose-dependent insulin secretion through the GIP receptor (GIPR) expressed in pancreatic β-cells ( Seino et al . 2013 ). GIPR is expressed in adipose tissue as well ( Joo et al . 2017 ). GIP plays an important role in high-fat diet (HFD

Open access

Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, and Margit Mahlapuu

sensitivity compared with wild-type littermates when both genotypes are fed a high-fat diet ( Cansby et al. 2013 ). Reciprocally, Stk25 knockout mice are protected against high-fat diet-induced whole-body glucose intolerance and insulin resistance compared

Open access

Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

patients with NAFLD ( Younossi et al . 2011 ). High-fat (HF) diets promote weight gain leading to an increase in adipose tissue mass (i.e. obesity). Simultaneously, these HF diets cause an increase in levels of circulating free fatty acids (FFAs) and

Open access

Stuart A Morgan, Laura L Gathercole, Zaki K Hassan-Smith, Jeremy Tomlinson, Paul M Stewart, and Gareth G Lavery

same genotype (‘young’). In a separate cohort, male C57BL/6 WT and 11β-HSD1 KO mice were maintained on normal chow for 18 months prior to being transferred to a 45% high-fat (HF) diet (composition in kcal: fat: 45%, carbohydrate: 35% protein: 20

Open access

David M Cartwright, Lucy A Oakey, Rachel S Fletcher, Craig L Doig, Silke Heising, Dean P Larner, Daniela Nasteska, Caitlin E Berry, Sam R Heaselgrave, Christian Ludwig, David J Hodson, Gareth G Lavery, and Antje Garten

by a diet high in saturated fat (60%) for 8 weeks (HFD), and whole-body energy metabolism and mitochondrial function were assessed. We found slight effects of NR on mitochondrial respiration in soleus muscle in both mouse strains that were not

Open access

Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker, and Ruth Andrew

aged 3 m were fed high-fat sucrose (58% kcal fat and 13% kcal sucrose) or control diet (10.5% kcal fat, 0% kcal sucrose; Research Diets Inc, New Brunswick, NJ, USA) for 4 weeks, subjected to GTT as above and culled ( n  = 10–18/group). Laboratory

Open access

David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, and Timothy Wells

)RNA Snord116 show mild hyperphagia, and impaired meal termination, coupled with leanness, even on a high-fat diet ( Ding et al . 2008 ). Given that single gene mutations constitute a rare subset of PWS individuals ( Sahoo et al . 2008 ) and display an

Open access

Laura L Gathercole, Nikolaos Nikolaou, Shelley E Harris, Anastasia Arvaniti, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, and Jeremy W Tomlinson

darkness cycle), temperature (21 ± 2°C) and humidity (55 ± 10%). They had free access to water (9–13 ppm chlorine) and standard diet (SDS Rat and Mouse No. 3 Breeding diet, RM3) until 10 weeks of age when they were transferred to a high fat (60% kcal from