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Ismael González-García, Pablo B Martínez de Morentin, Ánxela Estévez-Salguero, Cristina Contreras, Amparo Romero-Picó, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, Manuel Tena-Sempere, Sulay Tovar, and Miguel López

, Simonian & Herbison 1997 , Voisin et al. 1997 , Osterlund et al. 1998 , Merchenthaler et al. 2004 ). Recent evidence has shown that E2 has a nucleus-specific action in the hypothalamus to modulate energy homeostasis, particularly within the ARC and

Open access

Gisela Helfer and Qing-Feng Wu

of the hippocampus as well as ependymal cells and tanycytes lining the third ventricle of the hypothalamus ( Guo et al . 2012 , Helfer et al . 2016 ). CMKLR1 is a G i/o -protein-coupled receptor that signals through mitogen-activated protein kinase

Open access

Shona Wood and Andrew Loudon

in mice that lack rod photoreceptors ( Panda et al . 2003 ). Changes in duration of the light–darkness cycle are decoded in mammals within the supra-chiasmatic nucleus (SCN) of the hypothalamus. It has been proposed that altered phasing of clock

Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Cherl NamKoong, Abu Saleh Md Moin, Hideyuki Sakoda, and Masamitsu Nakazato

obesity and insulin resistance ( Hotamisligil et al . 1993 , Schenk et al . 2008 ). Obesity-associated inflammation, including enhanced expression of interleukin 1 beta (IL1β), tumor necrosis factor alpha (TNFα), and IL6 in the hypothalamus, was first

Open access

Georgina G J Hazell, Song T Yao, James A Roper, Eric R Prossnitz, Anne-Marie O'Carroll, and Stephen J Lolait

periventricular nucleus ++/+++/c  Lateral preoptic nucleus +/c  Medial preoptic nucleus ++/+++/c  Magnocellular preoptic area − Hypothalamus  Anterior commissural nucleus −  Anterior hypothalamic nucleus −  Arcuate nucleus +++  Dorsomedial nucleus −  Lateral

Open access

Ping Ye, Christopher J Kenyon, Scott M MacKenzie, Katherine Nichol, Jonathan R Seckl, Robert Fraser, John M C Connell, and Eleanor Davies

). Furthermore, although the presence of CYP11B2 transcripts was clearly demonstrable in brain stem, cerebral cortex, hippocampus, hypothalamus, and cerebellum, CYP11B2 expression only responded to dietary sodium restriction in the hippocampus and the

Open access

Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real, and Miguel López

administration of T 3 in the ventromedial nucleus of hypothalamus (VMH), via a mechanism dependent of AMPK. Notably, we also demonstrate that the expression of browning markers in WAT correlates with serum T 4 levels in humans. Thus, in addition to the well

Open access

Lisa L Koorneef, Jan Kroon, Eva M G Viho, Lucas F Wahl, Kim M L Heckmans, Marloes M A R van Dorst, Menno Hoekstra, René Houtman, Hazel Hunt, and Onno C Meijer

Introduction Glucocorticoids (GCs) are adrenal hormones involved in the stress response, regulating processes such as immune function and metabolism. The hypothalamus-pituitary-adrenal (HPA)-axis controls GC secretion via a cascade of hormonal

Open access

Alvaro Souto Padron, Ruy Andrade Louzada Neto, Thiago Urgal Pantaleão, Maria Carolina de Souza dos Santos, Renata Lopes Araujo, Bruno Moulin de Andrade, Monique da Silva Leandro, João Pedro Saar Werneck de Castro, Andrea Claudia Freitas Ferreira, and Denise Pires de Carvalho

these unequivocal effects on energy metabolism, 3,5-T2 might also affect the hypothalamus–pituitary–thyroid axis. Horst et al . (1995) have shown that 3,5-T2 treatment reduced serum thyroid-stimulating hormone (TSH) and thyroxine (T 4 ) levels as well

Open access

Dawn E W Livingstone, Emma M Di Rollo, Chenjing Yang, Lucy E Codrington, John A Mathews, Madina Kara, Katherine A Hughes, Christopher J Kenyon, Brian R Walker, and Ruth Andrew

-fixed. The hypothalamus, remaining brain, pituitary and other adrenal were frozen on soft dry ice. All samples were stored at −80 °C. Glucocorticoid clearance Weight matched (approximately 30 g) male WT and Srd5a1 -KO mice were adrenalectomised under