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K S Wilson, C S Tucker, E A S Al-Dujaili, M C Holmes, P W F Hadoke, C J Kenyon and M A Denvir

, results from controls of the dexamethasone group were not different from the controls in the hypoxia and GR morpholino group which were not exposed to ethanol. Previous work involving a dose-ranging study (1–200μM) established 100µM dexamethasone as the

Open access

Ekaterine Tskitishvili, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël and Jean-Michel Foidart

hypoxic–ischemic encephalopathy (HIE) remains a serious condition that causes significant mortality and morbidity in near-term and term newborns; also, it does occur in premature infants as well ( Volpe 2001 ). The brain damage due to hypoxia and ischemia

Open access

Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu and Pann-Ghill Suh

28 339 – 350 . ( doi:10.1055/s-0028-1091978 ) Lee M Hwang JT Lee HJ Jung SN Kang I Chi SG Kim SS Ha J 2003 AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target

Open access

Andrea Mafficini and Aldo Scarpa

inactivating mutations in the namesake gene, which is a negative regulator of the of the hypoxia-induced pro-proliferative HIF1 gene, a downstream effector of the PI3K/mTOR pathway as well; the VHL gene has also been reported to be frequently inactivated by

Open access

Colin P Sibley

). In pre-eclampsia, it is proposed that hypoxia and/or ischaemia-reperfusion lead to the release of free radicals and inflammatory mediators causing cellular stress in the syncytiotrophoblast (the placental epithelium) ( Powe et al . 2011 , Burton et

Open access

Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl and Karen E Chapman

associated with reduced adipose tissue hypoxia and inflammation ( Michailidou et al . 2012 ) and in cutaneous surgical wounds, where it is associated with improved wound repair ( Small et al . 2005 ). Here, we have generated mice deficient in 11β-HSD1 in

Open access

Joachim M Weitzel, Torsten Viergutz, Dirk Albrecht, Rupert Bruckmaier, Marion Schmicke, Armin Tuchscherer, Franziska Koch and Björn Kuhla

these defense enzymes seems to be a mechanism to allow for accumulating levels of peroxides and other reactive oxygen species, which in turn may activate transcription factors such as heat shock factor 1 ( HSF1 ) or hypoxia-inducible factor 1 ( HIF-1

Open access

David O'Regan, Christopher J Kenyon, Jonathan R Seckl and Megan C Holmes

nicotine impairs the maturation of both central and peripheral catecholaminergic pathways ( Navarro et al . 1990 ) and hypoxia alters development of sympathetic centres involved in BP regulation ( Peyronnet et al . 2002 ), effects which persist into

Open access

Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby and Margit Mahlapuu

Friess H Kleeff J 2009 Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma . Neoplasia 11 497 – 508 . ( doi:10.1593/neo.81618 ) Fukuda K Tesch GH Yap FY Forbes JM

Open access

Craig L Doig, Jamila Bashir, Agnieszka E Zielinska, Mark S Cooper, Paul M Stewart and Gareth G Lavery

generation . Journal of Biological Chemistry 281 6546 – 6551 . ( doi:10.1074/jbc.M512635200 ) Lee JH Gao Z Ye J 2013 Regulation of 11β-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-κB and HIF-1α