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Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby and Margit Mahlapuu

secondary antibodies (see Supplementary Table 1 for antibody information). The distribution of inflammatory cell infiltrate was assessed, and a total insulitis score was calculated as described previously ( Fukuda et al. 2008 ) in all islets present in

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Bernadette M Trojanowski, Heba H Salem, Heike Neubauer, Eric Simon, Martin Wagner, Rajkumar Dorajoo, Bernhard O Boehm, Leticia Labriola, Thomas Wirth and Bernd Baumann

extent the pathology found in type 2 diabetes patients ( Lee et al. 2017 ). IKK2-DN Pdx1 mice are non-obese and non-hyperinsulinaemic, and similar to AKITA mice they exhibit a reduction of their β-cell mass without insulitis and develop islet fibrosis