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Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu, and Pann-Ghill Suh

2008 ). Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic component of metabolic syndrome, which is highly associated with obesity and insulin resistance ( Postic & Girard 2008 ). A representative phenomenon of NAFLD is hepatic

Open access

Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole, and Jeremy W Tomlinson

Introduction Glucocorticoids (GCs) are steroid hormones that are released in response to stress and play a crucial role in inflammation and in carbohydrate, lipid and protein metabolism. Within key metabolic target tissues, notably the liver

Open access

Sandra Pereira, Wen Qin Yu, María E Frigolet, Jacqueline L Beaudry, Yaniv Shpilberg, Edward Park, Cristina Dirlea, B L Grégoire Nyomba, Michael C Riddell, I George Fantus, and Adria Giacca

animals. At the end of the clamp, rats were anesthetized, the liver was freeze-clamped with pre-cooled aluminum tongs, and the soleus muscle was collected. Tissues were stored at −80 °C. The tissue determinations have a lower n than the glucose kinetics

Open access

Joachim M Weitzel, Torsten Viergutz, Dirk Albrecht, Rupert Bruckmaier, Marion Schmicke, Armin Tuchscherer, Franziska Koch, and Björn Kuhla

likely that the TH system and TH-mediated signaling play a pivotal role in the control of substrate utilization and thus body temperature of heat-stressed cows. In order to distinguish between heat and energy intake-related effects, we analyzed the liver

Open access

Taira Wada, Yukiko Yamamoto, Yukiko Takasugi, Hirotake Ishii, Taketo Uchiyama, Kaori Saitoh, Masahiro Suzuki, Makoto Uchiyama, Hikari Yoshitane, Yoshitaka Fukada, and Shigeki Shimba

, Shimba et al. 2011 ). Conversely, obesity simultaneously decreases the expression of clock genes in each tissue; for example, a high-fat diet can alter the rhythmic expression of clock genes in the liver and the adipose tissue and affect behavioral

Open access

Alyce M Martin, Emily W Sun, and Damien J Keating

pathogenesis of human metabolic disorders. Gut hormone regulation of metabolism The regulation of whole-body metabolism involves the integrated activity of multiple metabolically active tissues, including the GI tract, pancreas, adipose tissue, liver

Open access

Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, and Stanley Andrisse

triglycerides and free fatty acids (FFA), thus driving lipid accumulation mainly in the liver ( Samuel & Shulman 2016 ). Previous work has shown that low-dose DHT female mice displayed obesity-independent impaired glucose tolerance, insulin resistance, and

Open access

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, and Masamitsu Nakazato

al. 2001 , Zigman et al. 2006 ). Liver-expressed antimicrobial peptide 2 (LEAP2), a 40 amino acid peptide, was originally isolated by comprehensive chromatographic characterization of human hemofiltrate ( Krause et al. 2003 ). Human LEAP2 is

Open access

Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovscki, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan, and Assaf Rudich

( Elgazar-Carmon et al . 2008 , Talukdar et al . 2012 ), but already could be tied to insulin resistance, particularly in the liver ( Elgazar-Carmon et al . 2008 , Hadad et al . 2013 ). The secretory profile of adipose tissue is thought to be altered

Open access

T Mracek, D Gao, T Tzanavari, Y Bao, X Xiao, C Stocker, P Trayhurn, and C Bing

al . 1998 ). Further, there is evidence that ZAG directly promotes lipid utilisation, possibly by the upregulation of mitochondrial uncoupling proteins ( Bing et al . 2002 ). ZAG has been identified in various organs, including the liver, breast