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Bernard Freudenthal, John Logan, Sanger Institute Mouse Pipelines, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

identification of extreme skeletal phenotypes in mutant mouse lines that carry single-gene knockouts representing all the known protein-coding genes. This approach has been made possible by the International Knockout Mouse Consortium (IKMC), whose aim is to

Open access

David M Cartwright, Lucy A Oakey, Rachel S Fletcher, Craig L Doig, Silke Heising, Dean P Larner, Daniela Nasteska, Caitlin E Berry, Sam R Heaselgrave, Christian Ludwig, David J Hodson, Gareth G Lavery, and Antje Garten

al. 2019 ) were conducted with male C57BL/6J or C57BL/6JRj mice (B6J), a commonly used mouse model to study the effects of diet-induced obesity and glucose intolerance. A limitation of using these mice for metabolic studies is a deficiency in

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu, and Itaru Kojima

function in MIN6 cells. Their results suggest that mouse T1R3 (mT1R3) is not totally insensitive to lactisole. Nevertheless, since their results are apparently contradictory to previous reports ( Johnson et al . 1994 , Jiang et al . 2005 ), investigators

Open access

David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, and Timothy Wells

. Insight into the relationship between the imprinted genes within the PWS cluster and impaired function has been gained by comparing the phenotype of mouse models bearing different PWS-associated mutations. For example, neonatal failure to thrive and early

Open access

Anne-Marie O'Carroll, Gillian M Howell, Emma M Roberts, and Stephen J Lolait

). In addition, Ucn III is expressed in mouse β-cells suggesting that the CRH system may be involved in the local regulation of pancreatic endocrine secretions ( Li et al . 2003 ). Indeed, accumulating evidence suggests that the CRH family of peptides

Open access

Ioannis Simitsidellis, Arantza Esnal-Zuffiaure, Olympia Kelepouri, Elisabeth O’Flaherty, Douglas A Gibson, and Philippa T K Saunders

mouse model to test the impact of two SARMs, GTx-007 (also known as Andarine, S4: ) and GTx-024 (Enobosarm, Ostarine: ) on uterine tissue and to

Open access

Nele Cielen, Nele Heulens, Karen Maes, Geert Carmeliet, Chantal Mathieu, Wim Janssens, and Ghislaine Gayan-Ramirez

deficiency per se may play a role in skeletal muscle dysfunction in COPD, we examined the time-course effect of chronic vitamin D deficiency on skeletal muscle function in a smoking mouse model. We used a vitamin D-deficient mouse model with normalized

Open access

A Edlund, M Barghouth, M Hühn, M Abels, J S E Esguerra, I G Mollet, E Svedin, A Wendt, E Renström, E Zhang, N Wierup, B J Scholte, M Flodström-Tullberg, and L Eliasson

et al. 2016 ). In both human and mouse, F508del-CFTR is misprocessed in the endoplasmatic reticulum and the channel is subsequently degraded. However, a small portion of F508del-CFTR escapes degradation and reaches the plasma membrane where it has

Open access

Emma Castrique, Marta Fernandez-Fuente, Paul Le Tissier, Andy Herman, and Andy Levy

used to drive the expression of Cre recombinase in the lactotrophs of PRL-Cre transgenic mice. In combination with the ROSA26-expression of yellow fluorescent protein (EYFP) reporter mouse, which has a fluorescent marker for Cre-driven recombination

Open access

T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

backgrounds to further study the role of MRAP2 in the regulation of energy homeostasis and the control of cholesterol and lipid metabolism. Materials and methods Generation of Mrap2 -deficient mouse Mice carrying the knockout-first conditional