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Katie J Mylonas, Neil A Turner, Sumia A Bageghni, Christopher J Kenyon, Christopher I White, Kieran McGregor, Robert A Kimmitt, Richard Sulston, Valerie Kelly, Brian R Walker, Karen E Porter, Karen E Chapman, and Gillian A Gray

Introduction Ischemic cell death associated with myocardial infarction (MI) prompts the recruitment and activation of immune cells to ensure repair ( Epelman & Mann 2012 , Frangogiannis 2012 ). Neutrophils are recruited early, removing

Open access

Lesley A Hill, Dimitra A Vassiliadi, Ioanna Dimopoulou, Anna J Anderson, Luke D Boyle, Alixe H M Kilgour, Roland H Stimson, Yoan Machado, Christopher M Overall, Brian R Walker, John G Lewis, and Geoffrey L Hammond

(RCL) that is characteristic of the SERPIN structure ( Gettins & Olson 2016 ). While CBG is not known to inhibit proteases, its RCL is cleaved by neutrophil elastase (NE) ( Hammond et al. 1990 ), chymotrypsin ( Lewis & Elder 2014 ) and Pseudomonas

Open access

Helen L Jeanes, Caroline Tabor, Darcey Black, Antwan Ederveen, and Gillian A Gray

mice ( Gabel et al . 2005 ). Neutrophils invade the myocardium during reperfusion and are an important source of oxidant stress causing injury ( Reimer et al . 1989 ). In vivo , the inhibition of myocardial adhesion molecule expression by oestrogen

Open access

Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl, and Karen E Chapman

following intra-peritoneal injection of thioglycollate (0.2 mL, 10%) were collected by lavage with 5mL ice-cold PBS ( Coutinho et al . 2016 ). At 24 h, cells comprise mainly neutrophils and monocytes, whereas the population is predominantly macrophages at

Open access

Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovscki, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan, and Assaf Rudich

. 2010 ). In mouse models amenable to detailed time-course analyses, even short-term (3 days) high-fat feeding (HFF) induced neutrophil-dominated adipose tissue inflammation. This inflammatory response clearly occurred before the development of obesity

Open access

Nele Cielen, Nele Heulens, Karen Maes, Geert Carmeliet, Chantal Mathieu, Wim Janssens, and Ghislaine Gayan-Ramirez

counts. Three hundred cells per mouse were counted to determine the number of neutrophils. Histopathology of the lungs The left lung was fixed in 6% v/v paraformaldehyde at a constant hydrostatic pressure of 25 cm H 2 O for 24 h and embedded in

Open access

Xiang Xiao, C Yan Cheng, and Dolores D Mruk

adhesion molecule (ICAM)-2 regulates angiogenesis . Blood 106 1636 – 1643 . ( doi:10.1182/blood-2004-12-4716 ) Huang MT Larbi KY Scheiermann C Woodfin A Gerwin N Haskard DO Nourshargh S 2006 ICAM-2 mediates neutrophil transmigration

Open access

Geoffrey L Hammond

now known that several endogenous proteases, including neutrophil elastase ( Hammond et al. 1990 ) and chymotrypsin ( Lewis & Elder 2014 ), and a protease (LasB) produced by the opportunistic bacterial pathogen, Pseudomonas aeruginosa ( Simard et

Open access

Gisela Helfer and Qing-Feng Wu

. In contrast, chemerin treatment reduces the recruitment of neutrophil and macrophages to the inflammatory sites and the expression of proinflammatory cytokine ( Cash et al . 2008 , Luangsay et al . 2009 ). These studies suggest that chemerin acts

Open access

Denys deCatanzaro and Tyler Pollock

leukocytes including neutrophils, eosinophils, macrophages and uterine natural killer cells ( Tibbetts et al . 1999 , Hunt et al . 2000 ). E 2 also facilitates transport of preimplantation embryos from the oviduct to the uterus ( Roblero & Garavagno 1979