combined stresses induced nuclear translocation of the receptor, whereas chronic stress does not induce GR translocation ( Fig. 1 ). Figure 1 Western-blot (WB) experiment demonstrating the effects of acute immobilization (A), chronic isolation (C), or
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Miroslav Adzic, Jelena Djordjevic, Ana Djordjevic, Ana Niciforovic, Constantinos Demonacos, Marija Radojcic, and Marija Krstic-Demonacos
Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole, and Jeremy W Tomlinson
nuclear receptors including the LXRs, GR, PXR and the retinoic acid receptor-related orphan receptors (RORs) ( Ma & Nelson 2019 ). In this regard, there is compelling evidence on the role of oxysterols as important mediators of metabolic syndrome
Karin L Gustafsson, Sofia Movérare-Skrtic, Helen H Farman, Cecilia Engdahl, Petra Henning, Karin H Nilsson, Julia M Scheffler, Edina Sehic, Ulrika Islander, Ellis Levin, Claes Ohlsson, and Marie K Lagerquist
-Letron I Guihot AL Boudou F Sautier L Vessieres E Kim SH 2014 Mutation of the palmitoylation site of estrogen receptor alpha in vivo reveals tissue-specific roles for membrane versus nuclear actions . PNAS 111 E283 – E290 . ( https://doi.org/10
Lisa Rice, Charlotte E Waters, Jennifer Eccles, Helen Garside, Paula Sommer, Paul Kay, Fiona H Blackhall, Leo Zeef, Brian Telfer, Ian Stratford, Rob Clarke, Dave Singh, Adam Stevens, Anne White, and David W Ray
Introduction Glucocorticoids (GC) act through the GC receptor (GR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors ( Hollenberg et al . 1985 , Weinberger et al . 1985 , 1987 , Perlmann & Evans 1997
J Fahrenkrug, B Georg, J Hannibal, and H L Jørgensen
evidence for the existence of a pituitary-independent thyroid clock in the rat by demonstrating 24-h antiphase oscillations for the transcripts of the canonical clock genes Per1 and Bmal1 and by visualising a daily cytoplasmatic–nuclear shuttling of PER
Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, and Stanley Andrisse
level ( Berlanga et al. 2014 ). Nuclear transcription factors (Liver X receptor (LxRα), sterol regulatory element-binding protein 1c (SREBP1c), carbohydrate-responsive element-binding protein (ChREBP), and farnesoid X receptor (FxR) and enzymes ACC1
Ann R Finch, Kathleen R Sedgley, Christopher J Caunt, and Craig A McArdle
). One of the key advances in this field has been the development of pharmacological chaperones that stabilize protein conformations that are more efficiently trafficked. In the case of seven transmembrane (7TM) receptors, at least ten diseases are linked
Sara Della Torre, Gianpaolo Rando, Clara Meda, Paolo Ciana, Luisa Ottobrini, and Adriana Maggi
the nuclear receptor (NR) family ( Tsai & O’Malley 1994 , Kininis & Kraus 2008 ). In addition, ERs may interfere with the signalling of other membrane receptors as well as intracellular receptors, and ERα, may associate with the plasma membrane and
Maria L Price, Cameron D Ley, and Caroline M Gorvin
the stomach. Activation requires acylation by the ghrelin-O-acyltransferase (GOAT) enzyme, which is itself released under fasted conditions ( Gutierrez et al. 2008 ). Ghrelin acts by binding to the growth hormone secretagogue receptor-1 (GHSR1), a G
Ekaterine Tskitishvili, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël, and Jean-Michel Foidart
, traditionally mediate their primary effects at the genomic level. In recent years, a large number of reports have described membrane-associated estrogen receptors, either similar to or distinct from the classical nuclear estrogen receptors ( Toran-Allerand et
