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Ya-Li Yang
Ya-Li Yang
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Li-Rong Ren
Li-Rong Ren
Shenzhen Key Laboratory of Birth Defects, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong, China
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Li-Feng Sun
Li-Feng Sun
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Chen Huang
Chen Huang
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
University of Chinese Academy of Sciences, Shenzhen, China
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University of Chinese Academy of Sciences, Shenzhen, China
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Tian-Xia Xiao
Tian-Xia Xiao
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Bao-Bei Wang
Bao-Bei Wang
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Jie Chen
Jie Chen
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Brian A Zabel
Brian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
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Peigen Ren
Peigen Ren
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Jian V Zhang
Jian V Zhang
Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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tissues in the human body, not only in liver and white adipose tissue, but also in placenta, skin, adrenal gland, lung, intestine, pancreas, and ovary ( Wittamer et al . 2003 ). The physiological functions of chemerin include regulation of blood pressure
Georgina G J Hazell
Georgina G J Hazell
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Song T Yao
Song T Yao
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James A Roper
James A Roper
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Eric R Prossnitz
Eric R Prossnitz
LINE, University of New Mexico, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
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Anne-Marie O'Carroll
Anne-Marie O'Carroll
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Stephen J Lolait
Stephen J Lolait
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glomerulosa of the cortex. In the kidney, GPR30-ir was present in the smooth-muscle cells of the pelvic region and to a lesser extent the medulla, with only a few positive cells in the cortex ( Fig. 6 B). In the ovary, dense staining was found within the
Jin Yu
Jin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Yuhuan Liu
Yuhuan Liu
Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China
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Danying Zhang
Danying Zhang
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Dongxia Zhai
Dongxia Zhai
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Linyi Song
Linyi Song
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Zailong Cai
Zailong Cai
Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China
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Chaoqin Yu
Chaoqin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 6–15% of women in their reproductive age ( Fauser et al. 2012 ). Hyperandrogenism, a hallmark of PCOS, is characterized by excessive
Tina Seidu
Tina Seidu
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
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Patrick McWhorter
Patrick McWhorter
Department of Chemistry, Youngstown State University, Youngstown, Ohio, USA
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Jessie Myer
Jessie Myer
Department of Biology, University of Missouri, Columbia, Missouri, USA
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Rabita Alamgir
Rabita Alamgir
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
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Nicole Eregha
Nicole Eregha
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
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Dilip Bogle
Dilip Bogle
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
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Taylor Lofton
Taylor Lofton
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
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Carolyn Ecelbarger
Carolyn Ecelbarger
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
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Stanley Andrisse
Stanley Andrisse
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Introduction Polycystic ovary syndrome (PCOS) affects 10–20% of reproductive-aged women. Hyperandrogenemia (HA) is a hallmark of PCOS. Impaired insulin signaling in white adipose tissue (WAT) promotes lipolysis leading to increased serum
Helen L Jeanes
Helen L Jeanes
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Caroline Tabor
Caroline Tabor
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Darcey Black
Darcey Black
Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Antwan Ederveen
Antwan Ederveen
Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Gillian A Gray
Gillian A Gray
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not have any influence on weight when given to rats receiving placebo or 17βE 2 ( Table 1 ). The uterine weights of all animals were recorded at the experimental end point to confirm the effective removal of the ovaries and successful hormone delivery
Ryun S Ahn
Ryun S Ahn
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Jee H Choi
Jee H Choi
Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea
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Bum C Choi
Bum C Choi
Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea
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Jung H Kim
Jung H Kim
Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea
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Sung H Lee
Sung H Lee
Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea
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Simon S Sung
Simon S Sung
Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea
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LH surge in rodents and humans has provided evidence that the SCN is also involved in regulating the function of the hypothalamus–pituitary–ovary (HPO) axis. The preovulatory LH surge occurs around the time of lights-off in nocturnal laboratory
Hiroyuki Enomoto
Hiroyuki Enomoto
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Kinuyo Iwata
Kinuyo Iwata
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Keisuke Matsumoto
Keisuke Matsumoto
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Mai Otsuka
Mai Otsuka
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Akio Morita
Akio Morita
Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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Hitoshi Ozawa
Hitoshi Ozawa
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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in the brain sections was also determined. Experiment 2 A silicon cannula (0.5-mm inner diameter; 1-mm outer diameter; Shin-Etsu Polymer, Tokyo, Japan) was inserted into the right atrium of 8- to 9-week-old rats with intact ovaries. On the
Carmen Corciulo
Carmen Corciulo
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Julia M Scheffler
Julia M Scheffler
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Piotr Humeniuk
Piotr Humeniuk
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Alicia Del Carpio Pons
Alicia Del Carpio Pons
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Alexandra Stubelius
Alexandra Stubelius
Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Ula Von Mentzer
Ula Von Mentzer
Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
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Christina Drevinge
Christina Drevinge
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Aidan Barrett
Aidan Barrett
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sofia Wüstenhagen
Sofia Wüstenhagen
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Matti Poutanen
Matti Poutanen
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland
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Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland
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Claes Ohlsson
Claes Ohlsson
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden
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Marie K Lagerquist
Marie K Lagerquist
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Ulrika Islander
Ulrika Islander
Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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were subjected to motor tests 2 and 8 weeks after DMM surgery. At 2 weeks post-DMM surgery, OVX mice showed a tendency toward decreased movement compared to mice with intact ovaries ( Fig. 3A , left). E2 treatment for 2 weeks increased both track length
Dawn E W Livingstone
Dawn E W Livingstone
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Emma M Di Rollo
Emma M Di Rollo
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Chenjing Yang
Chenjing Yang
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Lucy E Codrington
Lucy E Codrington
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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John A Mathews
John A Mathews
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Madina Kara
Madina Kara
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Katherine A Hughes
Katherine A Hughes
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Christopher J Kenyon
Christopher J Kenyon
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Brian R Walker
Brian R Walker
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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Ruth Andrew
Ruth Andrew
Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
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feedback loops mediated via the HPA axis has not been studied. Upregulation of 5α-reductase has been invoked to explain adrenal androgen excess in polycystic ovary syndrome ( Stewart et al . 1990 , Fassnacht et al . 2003 , Tsilchorozidou et al . 2003
J Fahrenkrug
J Fahrenkrug
Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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B Georg
B Georg
Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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J Hannibal
J Hannibal
Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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H L Jørgensen
H L Jørgensen
Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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the delayed feedback model of the oscillator. These findings are in accordance with our previous observations in the rat ovaries ( Fahrenkrug et al . 2006 ). As the expression and rhythmicity of the local clock in the thyroid gland was unaffected by
