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Alessandro Pocai

proteolytically cleaved in a tissue-specific manner by prohormone convertases 1 and 2. The numbers in the figure indicate amino acid positions in the 160-amino acid proglucagon sequence. In the pancreas, processing yields the glucagon sequence, whereas the region

Open access

Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee and Mehul T Dattani

feedback mediated by the hypothalamic–pituitary–thyroid (HPT) axis and centrally regulated by TRH ( Fig. 3 ). TRH is synthesized as a prohormone in the paraventricular nucleus (PVN) of the hypothalamus and matures into the TRH tripeptide amide (pGlu