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Denys deCatanzaro Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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Tyler Pollock Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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( Butcher et al . 1974 , Robker & Richards 1998 , Freeman 2006 ). Actions of E 2 at the hypothalamus can induce female sexual receptivity ( Pfaff 1980 ). After fertilization, E 2 influences the rate of passage of fertilized ova through the fallopian

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0247
Volume/Issue:
Volume 231: Issue 3
Open access
Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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assessment of isolated populations or deduced from cohort differences due to sex or suppression of endogenous hormones. It is well known that sexual dimorphism in immune responses affects the prevalence and severity of a range of inflammatory conditions, but

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0398
Volume/Issue:
Volume 261: Issue 3
Open access
Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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sexual differentiation of reproductive tissues, including the brain ( Phoenix et al. 1959 , Pang et al. 1979 , Tobet et al. 1986 , Korach et al. 1988 , Greco et al. 1991 , Rissman et al. 1997 , Nielsen et al. 2000 , Albrecht et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0003
Volume/Issue:
Volume 238: Issue 3
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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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progesterone ( Rider & Psychoyos 1994 ). Stromal cells proliferate and differentiate to form the maternal tissue referred to as the decidua that interfaces with the fetal placenta. Differentiation of stromal cells is accompanied by an increase in cell size

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0523
Volume/Issue:
Volume 229: Issue 2
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K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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differentiation and function. This knowledge may help to decipher those mechanisms surrounding joint pathology and ossification, and aid future research into effective disease-modifying therapies. In this review, we discuss aspects of cartilage and bone physiology

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0276
Volume/Issue:
Volume 219: Issue 1
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Nerine T Joseph Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Kevin Morgan Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robin Sellar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Derek McBride Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robert P Millar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Ian C Dunn Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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ovulatory cycle . Comparative Biochemistry and Physiology. Part A, Physiology 105 729 – 734 . Liu RC Lea RW Sharp PJ 1995 Sexually differentiated role of calcium ions in chicken GnRH-I-stimulated release of LH from anterior pituitary glands

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0544
Volume/Issue:
Volume 202: Issue 1
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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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implicated in the sexually dimorphic characteristics of prolactinomas described by some ( Ma et al . 2002 , Nishioka et al . 2003 , Delgrange et al . 2005 , Schaller 2005 ) but not all groups ( Calle-Rodrigue et al . 1998 ) and in the increased

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0474
Volume/Issue:
Volume 200: Issue 3
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David E Maridas Maine Medical Center Research Institute, Scarborough, Maine, USA

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Victoria E DeMambro Maine Medical Center Research Institute, Scarborough, Maine, USA

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Phuong T Le Maine Medical Center Research Institute, Scarborough, Maine, USA

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Kenichi Nagano Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Roland Baron Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Subburaman Mohan VA Loma Linda Healthcare System, Loma Linda, California, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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% penicillin/streptomycin. For BMSCs differentiation into osteoblasts, cells were plated in 6-well plates at 1,000,000 cells/cm 2 . Culture media was replenished every other day. Once cultures were confluent, cells were switched to an osteoblast

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0673
Volume/Issue:
Volume 233: Issue 1
Open access
Lianne Abrahams School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Nina M Semjonous School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Phil Guest School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Agnieszka Zielinska School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Beverly Hughes School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Gareth G Lavery School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Paul M Stewart School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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’ CRD is a continuum of hyperandrogenism with premature puberty due to mutations in H6PDH and 11β-HSD1 respectively ( Lavery 2007 , Lawson et al . 2011 ). In this regard, urinary steroidobolomics have been instrumental in differentiating ACRD from CRD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0178
Volume/Issue:
Volume 214: Issue 3
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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Shelley E Harris Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Toryn M Poolman Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Jonathan M Hazlehurst Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Denise V Kratschmar Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Marijana Todorčević Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ahmad Moolla Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Niall Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ryan C Pink Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Michael F Saikali Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Liz Bentley Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Claes Ohlsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Carolyn L Cummins Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Matti Poutanen Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Alex Odermatt Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Roger D Cox Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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. Figure 1 Hepatic and serum bile acids are lower in Akr1d1 –/– mice with sexually dimorphic changes to bile acid metabolism and composition. Mature (30 weeks) male and female Akr1d1 –/– mice have decreased total hepatic and serum bile acids (A) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0280
Volume/Issue:
Volume 253: Issue 3
Open access