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Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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8–9 h/night in 1960 to 7 h/night in 1995 ( Van Cauter & Knutson 2008 ). The prevalence of short sleep duration was reported as 45% in the United States in 2014, with a third of US adults not getting enough sleep (<7 h/night), which led the Centre for
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therefore characterised the metabolic phenotype of the PWS-IC del model in this study, quantifying appetitive and consummatory feeding behaviour, lipid profiling and storage, short-term responses to high-fat diet exposure and assessment of thermogenic
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Tokyo Adachi Hospital, Adachi, Tokyo, Japan
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KK-Ta mice, which are a polygenic model of metabolic syndrome with hypoadiponectinemia, have a shorter activity period under constant dark conditions and dampened circadian locomotor rhythms with increased light-phase activity relative to controls
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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metabolic syndrome, i.e. visceral fat accumulation, insulin resistance, hypertension and dyslipidemia ( Kalsbeek et al. 2015 ), and with a range of neuropsychiatric symptoms such as depression, impaired memory and sleep disturbances ( Pivonello et al
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years. Donors with young-onset (age <10 years) and short duration (<2 years); those with long duration (>35 years); and those with late-onset (age >30 years) receive less attention due to limited access. The need to study ‘all’ groups is highlighted by
Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA
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Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
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secretion. Injury to the hypothalamus can cause improper activation of the GH axis, leading to growth hormone deficiency (GHD) ( Kgosidialwa et al. 2019 ). GHD places children at risk for delayed skeletal maturation, short height, psychosocial difficulties
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK
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-A204E variant, which has a loss of constitutive activity in vitro , and has been identified in patients with short stature and obesity ( Pantel et al. 2006 ). Although this mutation abolishes constitutive activity, reduces body length, and impairs GH
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EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK
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discussed later in this review, anaesthetics, even when used for a very short period of time, may affect neuronal dynamics, lead to changes in hormone secretion, or alter animal behaviour. Head-fixed habituation For head-fixed experiments, it is useful