deletion analysis and transcription factor-binding site analysis, GATA-binding factor 1 (GATA1) was identified as a transcription factor most relevant to the HSD3B2 gene expression after cells were incubated with baicalin. To further confirm these results
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Jin Yu, Yuhuan Liu, Danying Zhang, Dongxia Zhai, Linyi Song, Zailong Cai, and Chaoqin Yu
Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani
) ( Garcia et al . 2014 ). Alternatively, as normal pituitary development depends on the sequential temporal and spatial expression of a cascade of signaling molecules and transcription factors, mutations in early ( HESX1, LHX3, LHX4, SOX3, OTX2 ) or late
Lei Zhang, Carol Paddon, Mark D Lewis, Fiona Grennan-Jones, and Marian Ludgate
-Akt (1:1000, room temperature, 1 h, Santa Cruz); and anti phospho-SYK (Tyr 352, 1:5000, overnight, 4 °C, BD Biosciences, San Jose, CA, USA). To investigate transcription factors, rabbit antibodies to phospho-PPARγ (Ser 82, 1:1000 overnight, 4 °C, Upstate
Sara Della Torre, Gianpaolo Rando, Clara Meda, Paolo Ciana, Luisa Ottobrini, and Adriana Maggi
oestrogen – are predominantly mediated through two distinct ERs (ERα and ERβ) that share a common phylogenetic origin, conserved structural organization and similar mode of action (mainly as ligand-operated transcription factors) with the other members of
A McMaster, T Chambers, Q-J Meng, S Grundy, A S I Loudon, R Donn, and D W Ray
translocating to the nucleus, and interacting with other transcription factors and transcriptional modulators ( Chen et al . 2001 , Stevens et al . 2003 , Garside et al . 2004 , O'Malley 2005 , McMaster & Ray 2007 ). In vivo target cells are subject to
Miroslav Adzic, Jelena Djordjevic, Ana Djordjevic, Ana Niciforovic, Constantinos Demonacos, Marija Radojcic, and Marija Krstic-Demonacos
-releasing hormone (CRH), brain-derived neurotropic factor (BDNF), and cytokines ( Goujon et al . 1997 , Schulkin et al . 1998 , Morsink et al . 2006 , Schulte-Herbruggen et al . 2006 ). The GR transcriptional activity is dependent on the cell type, the
Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby
transcription factors in macrophages ( Tsatsanis et al . 2006 ). These data contrast with the reduced IRS1 and AKT phosphorylation observed in the transgenic mice ( Jamieson et al . 2011 ), which may have been the result of the reduced circulating insulin
Shona Wood and Andrew Loudon
, including GFAP and S100 protein ( Hazlerigg et al . 2001 ). The PT has a distinct developmental origin from the rest of the pituitary gland, involving the bHLH transcription factor hairy enhancer of split ( HES1 ) as a PT-specific differentiating factor
Craig L Doig, Jamila Bashir, Agnieszka E Zielinska, Mark S Cooper, Paul M Stewart, and Gareth G Lavery
. 5 B). Figure 5 The NF-κB transcription factor p65 is recruited to the Hsd11b1 P1 promoter upon stimulation by TNFα. (A) RNA isolated from C2C12 myotubes was assessed for the expression of Hsd11b1 promoter 1 (P1), promoter 2 (P2), total and GAPDH
Qinglei Yin, Liyun Shen, Yicheng Qi, Dalong Song, Lei Ye, Ying Peng, Yanqiu Wang, Zhou Jin, Guang Ning, Weiqing Wang, Dongping Lin, and Shu Wang
. 2009 , Gao et al. 2012 , Kong et al. 2011 ). Moreover, SIRT1 is a critical suppressor of T-cell immunity that acts by suppressing the activity of transcription factors, such as nuclear factor kappa light chain enhancer of activated B cells (NF
