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Thomas Funck-Brentano Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Karin H Nilsson Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Robert Brommage Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Petra Henning Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ulf H Lerner Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Antti Koskela Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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Juha Tuukkanen Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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Martine Cohen-Solal BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France

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Sofia Movérare-Skrtic Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Claes Ohlsson Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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therapies targeting the WNT pathway have recently been described ( Smith et al. 2013 , O’Cearbhaill et al. 2016 ). Among them, vantictumab ( Smith et al. 2013 ), a monoclonal antibody against several Frizzled (FZD) receptors and ipafricept ( O

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0153
Volume/Issue:
Volume 238: Issue 1
Open access
K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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) , Tickle (2003) , Towers & Tickle (2009) and Wolpert (2010) ). Recent emerging evidence has suggested that planar cell polarity, a non-canonical WNT pathway involving the cadherins Fat and Dachsous (Fat/Dchs), is also important in embryonic skeletal

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https://doi.org/10.1530/JOE-13-0276
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Volume 219: Issue 1
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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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preimplantation uterus . Molecular Endocrinology 17 610 – 627 . ( doi:10.1210/me.2002-0290 ) Zimmerman ZF Moon RT Chien AJ 2012 Targeting Wnt pathways in disease . Cold Spring Harbor Perspectives in Biology 4 1 – 24 . ( doi:10

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DOI:
https://doi.org/10.1530/JOE-15-0523
Volume/Issue:
Volume 229: Issue 2
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Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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in the CTNNB1 gene, encoding β-catenin ( Buslei et al. 2005 ). These mutations are thought to impair the proteosomal degradation of this protein, resulting in its nucleo-cytoplasmic accumulation and subsequent upregulation of the Wnt pathway

Article Type:
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DOI:
https://doi.org/10.1530/JOE-17-0258
Volume/Issue:
Volume 236: Issue 1
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Erica Yeo Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

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Patricia L Brubaker Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada

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Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada

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investigated these signaling pathways in the maternal L-cell during pregnancy, although genetic variants of TCF proteins (nuclear Wnt pathway components) have been associated with the development of GDM ( Shaat et al. 2007 , Reyes-López et al. 2014 ). But

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Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-21-0354
Volume/Issue:
Volume 253: Issue 1
Open access