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Denys deCatanzaro Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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Tyler Pollock Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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gonadotropins. During the follicular phase of the cycle, E 2 stimulates uterine endometrial growth ( Garcia et al . 1988 ) and triggers a mid-cycle surge of luteinizing hormone (LH), which in turn induces ovulation and release of P 4 during the luteal phase

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Ya-Li Yang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Li-Rong Ren Shenzhen Key Laboratory of Birth Defects, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong, China

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Li-Feng Sun Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Chen Huang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
University of Chinese Academy of Sciences, Shenzhen, China

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Tian-Xia Xiao Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Bao-Bei Wang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Jie Chen Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Brian A Zabel Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA

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Peigen Ren Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Jian V Zhang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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female mice were injected i.p. with 5IU of pregnant mare serum gonadotropin (PMSG) (ProSpec, Ness-Ziona, Israel) to stimulate follicular development, followed by injection of 5IU of hCG (Sigma) 48h after PMSG injection to induce ovulation. Animals were

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Elizabeth M Simpson School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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Iain J Clarke School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia

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Christopher J Scott School of Dentistry and Medical Science, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia

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Cyril P Stephen School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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Alexandra Rao School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia

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Allan J Gunn School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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-releasing hormone (GnRH), luteinising hormone (LH) and follicle stimulating hormone (FSH), may delay puberty and delay the return to cyclicity following parturition or lactation. This is associated with reduced conception rates, reduced ovulation rates/ovulation

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David R Grattan Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand

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). In most mammalian species, there are two populations of kisspeptin neurons, with kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) playing an essential role in enabling ovulation in rodents by activating GnRH neurons

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F Wahab Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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M Shahab Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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R Behr Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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-negative feedback, estradiol-positive feedback during ovulation, as well as seasonal, circadian, metabolic, and stress signals to the reproductive axis ( Smith 2009 , 2013 , Castellano et al . 2010 a , b , Clarke & Caraty 2013 , Kriegsfeld 2013 , Sanchez

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L Nicol
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M-O Faure MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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J R McNeilly
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J Fontaine MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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C Taragnat MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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A S McNeilly
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production of these hormones is crucial, particularly in females, to coordinate follicle selection and terminal follicular growth as well as the timing and number of ovulations. Synthesis and release of LH and FSH are regulated by hypothalamic gonadotrophin

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Joachim M Weitzel Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Albrecht Institute of Microbiology, Ernst-Moritz-Arndt-University, Greifswald, Germany

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Rupert Bruckmaier Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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Marion Schmicke Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Hannover, Germany

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Armin Tuchscherer Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Franziska Koch Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Björn Kuhla Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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thyroid hormone deiodinase gene expression in dairy heifers on the day of ovulation and during the early peri-implantation period . Acta Veterinaria Scandinavica 58 52 . ( doi:10.1186/s13028-016-0231-6 ) 27608831 Mullur R Liu YY Brent GA

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Valentina Pampanini Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Daniela Germani Department of Systems Medicine, Tor Vergata University, Rome, Italy

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Antonella Puglianiello Department of Systems Medicine, Tor Vergata University, Rome, Italy

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Jan-Bernd Stukenborg Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Ahmed Reda Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Iuliia Savchuk Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Kristín Rós Kjartansdóttir Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Stefano Cianfarani Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden
Dipartimento Pediatrico Universitario Ospedaliero ‘Bambino Gesù’ Children’s Hospital – Tor Vergata University, Rome, Italy

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Olle Söder Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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postnatally undernourished female rats: follicular growth and ovulation after stimulation with pregnant mare serum gonadotropin at first cycle . Journal of Endocrinology 173 297 – 304 . ( doi:10.1677/joe.0.1730297 ) Erkkila K Aito H Aalto K

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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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diminishes the formation of uterine glands. The number of embryos recovered from the uteri of the mutant mice, however, was not different from wild-type mice, indicating that implantation failed in the mutants rather than an ovulation or embryo defect

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Matthew W S Lim School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Angela K Lucas-Herald School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Avril Mason Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Christian Delles School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Paul J Connelly School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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, albeit at a lower live birth rate ( Youssef et al. 2014 ). Following ovulation, the addition of GnRH agonist to progesterone for luteal phase support may improve the chance of a successful implantation ( Linden et al. 2015 ). A case–control study

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