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Open access

Sara Della Torre, Gianpaolo Rando, Clara Meda, Paolo Ciana, Luisa Ottobrini, and Adriana Maggi

active in most reproductive and non-reproductive tissue cells ( Ciocca & Roig 1995 , Maggi et al. 2004 , Bookout et al. 2006 ). Their expression and transcriptional activity in the course of embryo development is less studied ( Brandenberger et al

Open access

Miroslav Adzic, Jelena Djordjevic, Ana Djordjevic, Ana Niciforovic, Constantinos Demonacos, Marija Radojcic, and Marija Krstic-Demonacos

-releasing hormone (CRH), brain-derived neurotropic factor (BDNF), and cytokines ( Goujon et al . 1997 , Schulkin et al . 1998 , Morsink et al . 2006 , Schulte-Herbruggen et al . 2006 ). The GR transcriptional activity is dependent on the cell type, the

Open access

Lisa L Koorneef, Jan Kroon, Eva M G Viho, Lucas F Wahl, Kim M L Heckmans, Marloes M A R van Dorst, Menno Hoekstra, René Houtman, Hazel Hunt, and Onno C Meijer

the complex can bind to the DNA to induce or repress gene expression, generally involving parallel regulation of hundreds of genes. Eventual GR transcriptional activity is influenced by ligand concentration, receptor levels and the presence of

Open access

A McMaster, T Chambers, Q-J Meng, S Grundy, A S I Loudon, R Donn, and D W Ray

Introduction Glucocorticoid hormones exert a wide diversity of effects in target tissues. Their activity has been typically explored using a limited number of timed end points, both in vivo and in vitro , and using such approaches a variety of

Open access

Shona Wood and Andrew Loudon

. 2008 ). This SCN read-out of the photoperiod signal has all of the characteristics of an internal co-incidence timer, and is also reflected in changes in the patterns of SCN electrical activity ( Brown & Piggins 2009 ). The current dogma is that the

Open access

Craig L Doig, Jamila Bashir, Agnieszka E Zielinska, Mark S Cooper, Paul M Stewart, and Gareth G Lavery

transcriptional mechanisms in mature cells. Here, we demonstrate that in both a murine skeletal muscle cell line and primary cultured myotubes 11β-HSD1 expression and activity are suppressed following TNFα exposure, with anisomycin experiments attributing this

Open access

Jin Yu, Yuhuan Liu, Danying Zhang, Dongxia Zhai, Linyi Song, Zailong Cai, and Chaoqin Yu

inhibitor of HSD3B2 ( Nakamura et al. 2011 ), was chosen as a positive control ( Fig. 1E and F ). Baicalin repressed promoter activities of HSD3B2 via transcription factor GATA1 To obtain promoter–luciferase reporter constructs, the promoter DNA

Open access

Qinglei Yin, Liyun Shen, Yicheng Qi, Dalong Song, Lei Ye, Ying Peng, Yanqiu Wang, Zhou Jin, Guang Ning, Weiqing Wang, Dongping Lin, and Shu Wang

. 2009 , Gao et al. 2012 , Kong et al. 2011 ). Moreover, SIRT1 is a critical suppressor of T-cell immunity that acts by suppressing the activity of transcription factors, such as nuclear factor kappa light chain enhancer of activated B cells (NF

Open access

D Pugazhendhi, K A Watson, S Mills, N Botting, G S Pope, and P D Darbre

ligand-activated functions of these transcription factors on patterns of gene expression ( Woods 2003 ). Of the many phytoestrogens, the isoflavones genistein and daidzein can be consumed in relatively large amounts in soya bean-rich diets such as those

Open access

Dawn E W Livingstone, Sarah L Grassick, Gillian L Currie, Brian R Walker, and Ruth Andrew

urinary 5α-reduced metabolites can be accounted for by up-regulation of expression and activities of hepatic A-ring reductases ( Livingstone et al . 2005 ). 5αR1 is also expressed in adipose tissue but is not dysregulated in subcutaneous (s.c.) adipose in