Search Results

You are looking at 91 - 100 of 244 items for :

  • User-accessible content x
Clear All
Free access

Shin Tsunekawa, Naoki Yamamoto, Katsura Tsukamoto, Yuji Itoh, Yukiko Kaneko, Toshihide Kimura, Yoh Ariyoshi, Yoshitaka Miura, Yutaka Oiso, and Ichiro Niki

Introduction The beneficial effects of glucagon-like peptide 1 (GLP-1) and its related substances such as inhibitors of dipeptidyl peptidase IV, its degrading enzyme, on the pancreatic β-cells have been reported; these agents enhance

Free access

Hiranya Pintana, Nattayaporn Apaijai, Nipon Chattipakorn, and Siriporn C Chattipakorn

al . 2010 ). In this context, anti-diabetic agents such as rosiglitazone and glucagon-like peptide (GLP-1) have been reported to negate cognitive decline ( During et al . 2003 , Escribano et al . 2009 , Wang et al . 2011 ). Recently developed

Restricted access

Neil Tanday, Peter R Flatt, Nigel Irwin, and R Charlotte Moffett

incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), in T2DM have been linked to direct positive effects at the level of the endocrine pancreas. This includes, but not limited to, potentiation of glucose

Free access

Bethany P Cummings, Ahmed Bettaieb, James L Graham, Kimber Stanhope, Fawaz G Haj, and Peter J Havel

peroxisome proliferator receptor γ (PPARγ) and glucagon-like peptide 1 (GLP1). PPARγ is a nuclear receptor that is highly expressed in adipose tissue and macrophages and acts to upregulate the expression of factors involved in adipocyte differentiation and

Free access

Hidetada Ogata, Yusuke Seino, Norio Harada, Atsushi Iida, Kazuyo Suzuki, Takako Izumoto, Kota Ishikawa, Eita Uenishi, Nobuaki Ozaki, Yoshitaka Hayashi, Takashi Miki, Nobuya Inagaki, Shin Tsunekawa, Yoji Hamada, Susumu Seino, and Yutaka Oiso

Introduction Incretins, the gut hormones such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP1), which are secreted from enteroendocrine K-cells and L-cells, respectively, following meal ingestion stimulate

Free access

Weiwei Xu, Jamie Morford, and Franck Mauvais-Jarvis

acting on β cells, to facilitate the effect of testosterone in a paracrine manner. For that reason, we explored the possibility that AR action in β cells amplifies GLP-1R signaling to increase cAMP production. We reasoned that because GLP-1 is secreted by

Free access

Carmen Sanz, Isabel Roncero, Patricia Vázquez, M Angeles Navas, and Enrique Blázquez

glucose concentrations and peptides on GK gene promoter expression was tested in transiently transfected GT1-7 cells. Neither different glucose concentrations (2.8, 5.5, 10, or 20 mM) nor leptin (LEP), glucagon-like peptide 1 (GLP-1) or neuropeptide Y

Open access

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

test (ITT), and measurement of GIP and GLP-1 content in intestine were evaluated in the second cohort. Energy expenditure, food intake, and gene expression were evaluated in the third cohort. The mice were housed in an air-controlled 25°C room with a

Free access

Antonella Amato, Sara Baldassano, and Flavia Mulè

the gastrointestinal tract and in the brain, resulting in glucagon-like peptide-1 (GLP1), GLP2, intervening peptide-2, oxynthomodulin and glicentin ( Ugleholdt et al . 2004 ). The studies on proglucagon-derived peptides have supplied two classes of

Free access

Martin Haluzík, Helena Kratochvílová, Denisa Haluzíková, and Miloš Mráz

gastrointestinal tract with ghrelin, somatostatin and gastrin primarily produced in the stomach; GLP1 in jejunum, ileum and colon; GIP in duodenum; CCK in duodenum and jejunum and PYY in distal ileum and colon, respectively ( Meek et al . 2016 ). With the