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Beverly A S Reyes Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Hiroko Tsukamura Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Helen I’Anson Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Maria Amelita C Estacio Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Kanjun Hirunagi Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Kei-Ichiro Maeda Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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paraventricular hypothalamus: relationship to circadian rhythm and deprivation-induced eating behavior. Life Science 45 275 –282. Sugahara H , Akamine M, Kondo T, Fujisawa K, Yoshimasu K, Tokunaga S & Kudo C 2004 Somatic symptoms

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Hironobu Kobayashi Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Fukushi Kambe Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Tsuneo Imai Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Yatsuka Hibi Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Toyone Kikumori Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Sachiko Ohmori Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Akimasa Nakao Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Hisao Seo Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
Department of Breast and Endocrine Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Second Department of Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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that cell proliferation in this zone is associated with the circadian rhythm of plasma ACTH levels ( Miyamoto et al. 1999 ). Our results are partially compatible with these reports, although the cell proliferation observed in our study is mainly in

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Eva B Nygaard Global Research, Novo Nordisk A/S, Måløv, Denmark

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Cathrine Ørskov Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Thomas Almdal Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark

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Henrik Vestergaard NNF-CBMR, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Copenhagen, Denmark

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Birgitte Andersen Global Research, Novo Nordisk A/S, Måløv, Denmark

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a circadian rhythm during a 72-h fast in healthy female volunteers . Clinical Endocrinology 75 514 – 519 . ( https://doi.org/10.1111/j.1365-2265.2011.04084.x ) 10.1111/j.1365-2265.2011.04084.x 21521350 Badman MK Pissios P Kennedy AR Koukos G

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Luba Sominsky School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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Ilvana Ziko School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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Thai-Xinh Nguyen School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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Julie Quach School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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Sarah J Spencer School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia

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azide at 4°C until use. All experiments took place between 09:00 and 13:00 h to limit potential effects of circadian rhythms on any parameters measured. Immunohistochemistry Sections through the hypothalamus were immunolabelled for pSTAT3 (CL and

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Aurea Orozco
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Carlos Valverde-R
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Aurora Olvera
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Carlota García-G Instituto de Neurobiología, Departamento de Investigación Biomédica, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Juriquilla, Querétaro 76230, México

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/D3 and D2 is the fact that the latter exhibits a remarkable circadian rhythm entrained by the light/dark cycle. This rhythmicity has been documented in teleosts ( García-G et al . 2004 , Isorna et al . 2009 ), birds ( Yoshimura et al . 2003

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Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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mirror the oscillations of basal cortisol concentrations with the circadian rhythm ( Krug et al. 2014 ). Almost simultaneously, Benato et al . generated the Tg(9GCRE-HSV.Ul23:EGFP) ia20 transgenic zebrafish line, from herein named ia20 . The

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T’ng Choong Kwok University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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Roland H Stimson University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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, revealing key species-specific differences that emphasize the importance of studying BAT in humans ( Broeders et al. 2015 , Ramage et al. 2016 , Blondin et al. 2020 ). In addition, human brown adipocytes have been used to reveal the circadian rhythm

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Christina Antza Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Georgios Kostopoulos Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

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Samiul Mostafa Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Krishnarajah Nirantharakumar Institute of Applied Health Research, University of Birmingham, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Abd Tahrani Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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. ( https://doi.org/10.1210/jc.2014-3911 ) 25658017 Rao R Somvanshi P Klerman EB Marmar C Doyle 3rd FJ 2021 Modeling the influence of chronic sleep restriction on cortisol circadian rhythms, with implications for metabolic disorders

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Richard R Almon Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Debra C DuBois Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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William Lai Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Bai Xue Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Jing Nie Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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William J Jusko Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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with WKY rats. Because we only measured expression at one time within the 24-h cycle, we cannot determine whether the difference between GK and WKY reflects a disturbance in circadian rhythms in GK rats, which itself has been shown to contribute to

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Gary B Silberstein Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA

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Katharine Van Horn Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA

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Eva Hrabeta-Robinson Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA

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Jennifer Compton Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA

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& Virshup DM 2005 Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Molecular and Cellular Biology 25 2795 –2807. El Khissiin A & Leclercq G 1999 Implication of

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