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Hnin ThidarMyint Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan

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Hiroko Yoshida Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan

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Tetsuya Ito Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan

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Hideto Kuwayama Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro 080-8555, Japan

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elevated plasma ghrelin may mimic the temporary negative energy balance in heifers because plasma ghrelin levels were elevated in conditions of energy insufficiency ( Korbonits et al. 2004 , Anderson et al. 2005 ). In addition, ghrelin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06746
Volume/Issue:
Volume 189: Issue 3
Free access
María F Andreoli Laboratory of Experimental Neurodevelopment, Institute of Development and Paediatric Research (IDIP), La Plata Children’s Hospital and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), La Plata, Buenos Aires, Argentina
Argentine Research Council (CONICET), La Plata, Buenos Aires, Argentina

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Jose Donato Jr Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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Isin Cakir Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA

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Mario Perello Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology (IMBICE, Argentine Research Council (CONICET), National University of La Plata and Scientific Research Commission, Province of Buenos Aires (CIC-PBA)), La Plata, Buenos Aires, Argentina

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1077 recruits STAT5, which mediates some effects of leptin on energy balance and reproduction as well as effects of prolactin ( Tups 2009 ). Leptin-induced JAK2 activation also leads to the phosphatidylinositol 3-kinase (PI3K) activation, which is the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0606
Volume/Issue:
Volume 241: Issue 3
Free access
L van Bloemendaal
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J S ten Kulve
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S E la Fleur Diabetes Centre, Department of Endocrinology and Metabolism, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands

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R G Ijzerman
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M Diamant
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, such as cardiovascular disease and cancer ( Stratton et al . 2000 , Field et al . 2001 ). Obesity is the result of a long-term positive energy balance whereby energy intake surpasses expenditure. The CNS plays a major role in the maintenance of body

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0414
Volume/Issue:
Volume 221: Issue 1
Free access
Adrian Holliday School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK
Carnegie School of Sport, Leeds Beckett University, Headingley Campus, Leeds, UK

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Andrew Blannin School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK

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. However, the monitoring of food intake, physical activity and metabolic rate over the course of the whole day and beyond would be required to determine likely effects of the exercise bout, and subsequent appetite response, on energy balance. The post

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0570
Volume/Issue:
Volume 235: Issue 3
Free access
Jimena Laporta Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Spencer A E Moore Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Samantha R Weaver Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Callyssa M Cronick Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Megan Olsen Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Austin P Prichard Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Brian P Schnell Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Thomas D Crenshaw Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Francisco Peñagaricano Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Rupert M Bruckmaier Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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Laura L Hernandez Departments of Dairy Science, Animal Sciences, Veterinary Physiology, University of Wisconsin‐Madison, 1675 Observatory Drive, Madison, Wisconsin 53706, USA

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in the regulation of energy balance ( Tecott 2007 ), mainly through the modulation of glucose and lipid metabolism. The liver expresses TPH1 and several serotonin receptor subtypes ( Papadimas et al . 2012 ). Serotonin is thought to mediate hepatic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0693
Volume/Issue:
Volume 226: Issue 1
Free access
Clare M Reynolds Liggins Institute, University of Auckland, Auckland, New Zealand

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Mark H Vickers Liggins Institute, University of Auckland, Auckland, New Zealand

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a negative feedback loop to maintain homeostatic control of adipose tissue mass. This then stimulates a negative energy balance controlling appetite and increasing energy expenditure ( Friedman 2016 ). Leptin also exerts its actions across a wide

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0686
Volume/Issue:
Volume 242: Issue 1
Free access
M J Vazquez Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain

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I Velasco Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain

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M Tena-Sempere Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain
FiDiPro Program, Department of Physiology, University of Turku, Turku, Finland

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), and hence, is essential for maintenance of energy balance at the whole body level ( Martins et al. 2012 ). In this context, studies carried out in our group demonstrated that hypothalamic mTOR plays an important role in the metabolic control of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0223
Volume/Issue:
Volume 242: Issue 2
Free access
Silvana Y Romero-Zerbo Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Alex Rafacho Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Adenis Díaz-Arteaga Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Juan Suárez Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ivan Quesada Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Mónica Imbernon Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ruth A Ross Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Carlos Dieguez Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Fernando Rodríguez de Fonseca Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Rubén Nogueiras Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Ángel Nadal Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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Francisco J Bermúdez-Silva Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain
Fundación IMABIS, Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Institute of Medical Sciences, Neurocentre Magendie, Hospital Carlos Haya de Málaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, sótano, Avenida Carlos Haya 82, 29010 Málaga, Spain

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macrophages. However, at present there is no data regarding the putative role of GPR55 in metabolism or glucose homeostasis. By contrast, the cannabinoid CB1 receptor is a well-known player in controlling energy balance ( Pagotto et al . 2006 ). In fact, the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0166
Volume/Issue:
Volume 211: Issue 2
Free access
Brenton T Laing Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA

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Khoa Do Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA

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Tomoko Matsubara Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA

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David W Wert East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA

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Michael J Avery Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA

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Erin M Langdon Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA

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Donghai Zheng Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, Collage of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA

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Hu Huang Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA
Human Performance Laboratory, Collage of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA
Department of Physiology, East Carolina University, Greenville, North Carolina, USA

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detailing how exercise training mechanistically induces weight loss via neurological control of energy balance and body weight in obese subjects. Given the facts, certain areas within the hypothalamus, such as ARC, VMH, DMH, and PVH, play important roles in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0510
Volume/Issue:
Volume 229: Issue 2
Free access
Sabina Börner
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Michael Derno
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Sandra Hacke
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Ulrike Kautzsch
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Christine Schäff
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Sint ThanThan Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Hideto Kuwayama Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Harald M Hammon
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Monika Röntgen
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Rosemarie Weikard Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Christa Kühn Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Armin Tuchscherer Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Björn Kuhla
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nutritional state in situations of positive energy balance (EB). Wertz-Lutz et al . (2006) found a weak increase in feed intake upon acyl ghrelin injection; however, neither s.c. ( Roche et al . 2008 ) nor centrally infused acyl ghrelin ( Iqbal et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0384
Volume/Issue:
Volume 216: Issue 2
Free access