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Sharon Maor Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Doris Mayer Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Ronit I Yarden Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Adrian V Lee Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Rive Sarfstein Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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Moshe Z Papa Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Group on Hormones and Signal Transduction, German Cancer Research Center, Heidelberg D-69120, Germany
Laboratory of Genomic Applications, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Department of Oncological Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel

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WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. Journal of Biological Chemistry 278 3474 –3482. Khan S , Abdelrahim M, Samudio I & Safe S 2003 Estrogen receptor/Sp1 complexes are

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L Grinius Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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C Kessler Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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J Schroeder Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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S Handwerger Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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, Nakamura N, Sansal I, Bergeron L & Sellers WR 2002 A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2 81 –91. Rena G , Guo S, Cichy SC, Unterman TG

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C Giuliani Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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M Saji Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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I Bucci Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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G Fiore Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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M Liberatore Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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D S Singer Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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F Monaco Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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L D Kohn Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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G Napolitano Unit of Endocrinology, Department of Medicine and Sciences of Aging, University ‘G D’Annunzio’ and Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Campus Universitario, via Colle dell’Ara, 66013 Chieti, Italy
Arthur G Janes Cancer Center and Richard J Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Unit of Immuno-oncology Aging Research Center, Ce.S.I., ‘Gabriele D’Annunzio’ University Foundation, Chieti-Pescara, Italy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA

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, Medina & Santisteban 2000 ). The pathophysiologic relevance of these data needs to be confirmed with studies on different systems. However, the reliability of FRTL-5 cells as a model to study MHC gene regulation has been validated by studies conducted in

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M-J Kim Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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J-H Kang Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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Y G Park Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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G R Ryu Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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S H Ko Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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I-K Jeong Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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K-H Koh Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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D-J Rhie Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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S H Yoon Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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S J Hahn Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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M-S Kim Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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Y-H Jo Departments of Physiology and
Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
Department of Biochemistry, College of Medicine, Korea University, Seoul 136-701, Korea
Department of Internal Medicine, School of Medicine, Hallym University, Seoul 150-030, Korea
Department of Food Science and Nutrition, The Catholic University of Korea, Puchon City 420-743, Korea

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postnatal pancreatic β-cell growth. Molecular and Cellular Biology 25 3752 –3762. Lalli E & Sassone-Corsi P 1994 Signal transduction and gene regulation. Journal of Biological Chemistry 269 17359 –17362

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J E Sánchez-Criado Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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J Martín de las Mulas Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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C Bellido Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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V M Navarro Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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R Aguilar Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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J C Garrido-Gracia Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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M M Malagón Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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M Tena-Sempere Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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A Blanco Departments of Cell Biology, Physiology and Immunology and
Comparative Pathology, University of Córdoba, Avda. Menendez Pidal s/n, 14004 Córdoba, Spain

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acetylene and polar analogues. Journal of Medicinal Chemistry 44 4230 –4251. Mitchner NA , Garlick C & Ben-Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptor α and β in the rat pituitary gland

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John Le Lay Department of Molecular Physiology and Biophysics, Vanderbilt University, 2001 West End Ave Nashville, Tennessee 37235, USA

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Roland Stein Department of Molecular Physiology and Biophysics, Vanderbilt University, 2001 West End Ave Nashville, Tennessee 37235, USA

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insulin/simian virus 40 oncogenes. Nature 315 115 –122. Iype T , Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffien SC & Mirmira RG 2005 Mechanism of insulin gene regulation by the

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Akiko Katoh Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Hiroaki Fujihara Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Toyoaki Ohbuchi Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Tatsushi Onaka Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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W Scott Young III Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Govindan Dayanithi Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Yuka Yamasaki Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Mitsuhiro Kawata Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Hitoshi Suzuki Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Hiroki Otsubo Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Hideaki Suzuki Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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David Murphy Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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Yoichi Ueta Departments of, Physiology, Otorhynolaryngology, Department of Physiology, Section on Neural Gene Expression, Department of Cellular Neurophysiology, Department of Anatomy and Neurobiology, Molecular Neuroendocrinology Research Group, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

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critical reading and language editing of the manuscript. References Abbott A 2004 The renaissance rat . Nature 428 464 – 466 . Burbach JP Luckman SM Murphy D Gainer H 2001 Gene regulation in the magnocellular hypothalamo

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Yu Wang Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Fan Li Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Xiaoqian Gao Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Huahui Yu Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Zhiyong Du Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Linyi Li Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Yunhui Du Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Chaowei Hu Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Yanwen Qin Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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-5p reduces cholesterol levels, we used TargetScan8.0 and miRWALK to predict possible target genes regulated by miR-181d-5p. This analysis identified PCSK9 , which is associated with the LDL-C clearance pathway. The mechanism of miRNA-mediated gene

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Pengli Bu Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Shintaro Yagi Laboratory of Cellular Biochemistry, Veterinary Medical Sciences/Animal Resource Sciences, The University of Tokyo, Tokyo, Japan

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Kunio Shiota Laboratory of Cellular Biochemistry, Veterinary Medical Sciences/Animal Resource Sciences, The University of Tokyo, Tokyo, Japan
Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

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S M Khorshed Alam Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Jay L Vivian Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Michael W Wolfe Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M A Karim Rumi Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Damayanti Chakraborty Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Kaiyu Kubota Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Pramod Dhakal Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Michael J Soares Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA

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. Furthermore, comparisons of rodent amino acid sequences indicated that proteins encoded by the Prl3c1 gene have undergone positive selection ( Chuong et al. 2010 ), a measure of a rapidly evolving gene. Regulation of Prl3c1-v1 vs Prl3c1-v2

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Dipali Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Sean W Limesand School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Ravi Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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have emerged as essential players in post-transcriptional gene regulation. These are subtypes of small, noncoding RNA, 21–25 nucleotides in length. miRNAs are capable of base pairing with mRNA, and fine-tuning gene expression during development and

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