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Saleela M Ruwanpura Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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Robert I McLachlan Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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Sarah J Meachem Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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accumulate suggesting failed physiological apoptosis ( Knudson et al . 1995 , Russell et al . 2002 ), and when Apaf1 was removed via gene-targeted deletion, high numbers of degenerating spermatogonia were observed. ( Honarpour et al . 2000

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S F Ahmed
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C Farquharson Developmental Endocrinology Research Group, Bone Biology Group, Division of Developmental Medicine, Department of Child Health, Royal Hospital For Sick Children, University of Glasgow, Yorkhill, Glasgow G3 8SJ, UK

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gene targeting. In Molecular mechanisms to Regulate the Activities of Insulin-like Growth Factors , pp 57–63. Eds T Katano, N Hizuka & SI Takahashi. Elsevier: Amsterdam.. Wong SC Hassan K McGrogan P Weaver LT Ahmed SF 2007 The effects of

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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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outcome after tamoxifen treatment ( Zwart et al. 2011 ). This link between SRC3 gene targets and tamoxifen treatment is in line with previous reports describing increased SRC3 expression, in combination with increased ERBB2 expression, to correlate with

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Bruce S McEwen Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Jason D Gray Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Carla Nasca Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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unexplored set of new gene targets that have been identified, which are activated by stress, but function outside of traditional CORT or inflammatory signaling pathways. Epigenetic regulation: search for rapidly acting treatments Although the action of

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Pauline Campos College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK

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Jamie J Walker College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK
EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK

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Patrice Mollard IGF, University of Montpellier, CNRS, INSERM, Montpellier, France

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) Vasileva A Jessberger R 2005 Precise hit: adeno-associated virus in gene targeting . Nature Reviews: Microbiology 3 837 – 847 . ( https://doi.org/10.1038/nrmicro1266 ) Viskaitis P Irvine EE Smith MA Choudhury AI Alvarez-Curto E

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Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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. Drugs Indication Circadian gene target Dipeptidyl peptidase-4 inhibitors Diabetes mellitus DPP4 Gliclazide Diabetes mellitus ABCC8 and VEGFA Glimepiride Diabetes mellitus KCNJ1 and ABCC8 Insulin

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Sunita M C De Sousa Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Nèle F Lenders Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Lydia S Lamb Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Warrick J Inder Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia
Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia

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Ann McCormack Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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-specific medical therapy does not yet exist in familial pituitary tumours, but gene-targeted treatments are rapidly evolving across medicine. PARP inhibitors, used in the treatment of patients with BRCA1/2 -mutated cancers, have been shown to decrease cell

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Femke L Groeneweg
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Henk Karst Department of Medical Pharmacology, Department of Neuroscience and Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands

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E Ron de Kloet
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Marian Joëls Department of Medical Pharmacology, Department of Neuroscience and Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands

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: search for gene targets . European Journal of Pharmacology 583 272 – 289 doi:10.1016/j.ejphar.2007.11.070 . Di S Malcher-Lopes R Halmos KC Tasker JG 2003 Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus

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Chen-Che Jeff Huang Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

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Yuan Kang Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

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Zavarsek S Hasthorpe S Drago J de Kretser D Hertzog PJ , et al . 2001 Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs . Genome Research 11 1327 – 1334

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Bo Chen Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China
Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China

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Yanrong Lu Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China

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Younan Chen Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China

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Jingqiu Cheng Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China

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tandem NF-E2/AP1 repeat of the β-globin locus control region . PNAS 91 9926 – 9930 . ( doi:10.1073/pnas.91.21.9926 ) Morin P Jr Ni Z McMullen DC Storey KB 2008 Expression of Nrf2 and its downstream gene targets in hibernating 13-lined

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