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accumulate suggesting failed physiological apoptosis ( Knudson et al . 1995 , Russell et al . 2002 ), and when Apaf1 was removed via gene-targeted deletion, high numbers of degenerating spermatogonia were observed. ( Honarpour et al . 2000
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gene targeting. In Molecular mechanisms to Regulate the Activities of Insulin-like Growth Factors , pp 57–63. Eds T Katano, N Hizuka & SI Takahashi. Elsevier: Amsterdam.. Wong SC Hassan K McGrogan P Weaver LT Ahmed SF 2007 The effects of
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outcome after tamoxifen treatment ( Zwart et al. 2011 ). This link between SRC3 gene targets and tamoxifen treatment is in line with previous reports describing increased SRC3 expression, in combination with increased ERBB2 expression, to correlate with
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unexplored set of new gene targets that have been identified, which are activated by stress, but function outside of traditional CORT or inflammatory signaling pathways. Epigenetic regulation: search for rapidly acting treatments Although the action of
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EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK
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) Vasileva A Jessberger R 2005 Precise hit: adeno-associated virus in gene targeting . Nature Reviews: Microbiology 3 837 – 847 . ( https://doi.org/10.1038/nrmicro1266 ) Viskaitis P Irvine EE Smith MA Choudhury AI Alvarez-Curto E
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. Drugs Indication Circadian gene target Dipeptidyl peptidase-4 inhibitors Diabetes mellitus DPP4 Gliclazide Diabetes mellitus ABCC8 and VEGFA Glimepiride Diabetes mellitus KCNJ1 and ABCC8 Insulin
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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-specific medical therapy does not yet exist in familial pituitary tumours, but gene-targeted treatments are rapidly evolving across medicine. PARP inhibitors, used in the treatment of patients with BRCA1/2 -mutated cancers, have been shown to decrease cell
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: search for gene targets . European Journal of Pharmacology 583 272 – 289 doi:10.1016/j.ejphar.2007.11.070 . Di S Malcher-Lopes R Halmos KC Tasker JG 2003 Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus
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Zavarsek S Hasthorpe S Drago J de Kretser D Hertzog PJ , et al . 2001 Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs . Genome Research 11 1327 – 1334
Key Laboratory of Transplant Engineering and Immunology, Department of Human Anatomy, Ministry of Health, Regenerative Medicine Research Center, West China Hospital, Sichuan University, No.1, Keyuan Road 4th, Wuhou District, Chengdu, Sichuan Province 610041, People's Republic of China
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tandem NF-E2/AP1 repeat of the β-globin locus control region . PNAS 91 9926 – 9930 . ( doi:10.1073/pnas.91.21.9926 ) Morin P Jr Ni Z McMullen DC Storey KB 2008 Expression of Nrf2 and its downstream gene targets in hibernating 13-lined
