identified (reviewed by Moller et al . (2003) ). In pancreatic islets, receptors have been identified on both α- and β-cells ( Strowski et al . 2000 , Cejvan et al . 2003 ) and exogenously administered SST inhibits both insulin and glucagon secretion
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Astrid C Hauge-Evans, James Bowe, Zara J Franklin, Zoheb Hassan and Peter M Jones
A L Pierce, M Shimizu, L Felli, P Swanson and W W Dickhoff
the primary hormonal regulators of liver IGFBP-1 production, other anabolic and catabolic hormones also play roles. In general, growth hormone (GH) decreases and glucagon increases hepatocyte IGFBP-1 mRNA levels ( Denver & Nicoll 1994 , Kachra et al
Jennifer S ten Kulve, Dick J Veltman, Liselotte van Bloemendaal, Paul F C Groot, Henricus G Ruhé, Frederik Barkhof, Michaela Diamant and Richard G Ijzerman
, Cummings 2013 ), except for glucagon-like peptide-1 (GLP1). GLP1 is a gut-derived hormone, mainly known for its glucose-lowering effects ( Kreymann et al. 1987 , Mojsov et al. 1987 ); however, numerous preclinical and clinical studies have shown that
Amy R Quinn, Cynthia L Blanco, Carla Perego, Giovanna Finzi, Stefano La Rosa, Carlo Capella, Rodolfo Guardado-Mendoza, Francesca Casiraghi, Amalia Gastaldelli, Marney Johnson, Edward J Dick Jr and Franco Folli
both types of this disease has been linked to loss of β-cell mass, impaired β-cell function, as well as increased glucagon secretion. The potential for β-cell regeneration in humans is an area under active investigation ( Dhawan et al . 2007 , Karaca
Angela S Bang, Steven G Soule, Tim G Yandle, A Mark Richards and Chris J Pemberton
) or glucose administration alone ( Shiiya et al. 2002 ). However, the in vivo physiological contributions of putative ghrelin secretagogues, including insulin, glucagon and leptin remain unclear or controversial ( Korbonits et al. 2004 , Soule
Sandra K Szlapinski, Anthony A Botros, Sarah Donegan, Renee T King, Gabrielle Retta, Brenda J Strutt and David J Hill
novel postpartum data in this study ( Szlapinski et al. 2019 ). Following the IPGTT, maternal (F1) blood was collected via cardiac puncture in order to quantify serum insulin, glucagon, and PD-L1 quantified using an Ultra Sensitive Mouse Insulin ELISA
Sehee Kim, Minho Moon and Seungjoon Park
pharmacological intervention of MMP-3 and microglial activation could be considered as plausible candidates for neuroprotective agents in PD. Glucagon-like peptide-1 (GLP-1), an endogenous 30-amino acid gut–brain peptide hormone, is synthesized from proglucagon
Weiwei Xu, Jamie Morford and Franck Mauvais-Jarvis
induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival . Diabetologia 54 2067 – 2076 . ( https://doi.org/10.1007/s00125-011-2181-x ) 10.1007/s00125-011-2181-x 21567300 Lubahn DB Joseph DR Sullivan PM Willard
Yi Zhao, Tao Liu, Nina Zhang, Fenghua Yi, Qinghua Wang, Ivan George Fantus and Tianru Jin
Introduction Pancreatic islets consist of three major types of endocrine cells, synthesizing three different peptide hormones that are important in blood glucose homeostasis. These include glucagon-producing α cells, insulin
Benjamin J Lamont and Sofianos Andrikopoulos
Introduction The incretins glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) act via specific G-protein-coupled receptors to potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner
