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Astrid C Hauge-Evans, James Bowe, Zara J Franklin, Zoheb Hassan and Peter M Jones

identified (reviewed by Moller et al . (2003) ). In pancreatic islets, receptors have been identified on both α- and β-cells ( Strowski et al . 2000 , Cejvan et al . 2003 ) and exogenously administered SST inhibits both insulin and glucagon secretion

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A L Pierce, M Shimizu, L Felli, P Swanson and W W Dickhoff

the primary hormonal regulators of liver IGFBP-1 production, other anabolic and catabolic hormones also play roles. In general, growth hormone (GH) decreases and glucagon increases hepatocyte IGFBP-1 mRNA levels ( Denver & Nicoll 1994 , Kachra et al

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Jennifer S ten Kulve, Dick J Veltman, Liselotte van Bloemendaal, Paul F C Groot, Henricus G Ruhé, Frederik Barkhof, Michaela Diamant and Richard G Ijzerman

, Cummings 2013 ), except for glucagon-like peptide-1 (GLP1). GLP1 is a gut-derived hormone, mainly known for its glucose-lowering effects ( Kreymann et al. 1987 , Mojsov et al. 1987 ); however, numerous preclinical and clinical studies have shown that

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Amy R Quinn, Cynthia L Blanco, Carla Perego, Giovanna Finzi, Stefano La Rosa, Carlo Capella, Rodolfo Guardado-Mendoza, Francesca Casiraghi, Amalia Gastaldelli, Marney Johnson, Edward J Dick Jr and Franco Folli

both types of this disease has been linked to loss of β-cell mass, impaired β-cell function, as well as increased glucagon secretion. The potential for β-cell regeneration in humans is an area under active investigation ( Dhawan et al . 2007 , Karaca

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Angela S Bang, Steven G Soule, Tim G Yandle, A Mark Richards and Chris J Pemberton

) or glucose administration alone ( Shiiya et al. 2002 ). However, the in vivo physiological contributions of putative ghrelin secretagogues, including insulin, glucagon and leptin remain unclear or controversial ( Korbonits et al. 2004 , Soule

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Sandra K Szlapinski, Anthony A Botros, Sarah Donegan, Renee T King, Gabrielle Retta, Brenda J Strutt and David J Hill

novel postpartum data in this study ( Szlapinski et al. 2019 ). Following the IPGTT, maternal (F1) blood was collected via cardiac puncture in order to quantify serum insulin, glucagon, and PD-L1 quantified using an Ultra Sensitive Mouse Insulin ELISA

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Sehee Kim, Minho Moon and Seungjoon Park

pharmacological intervention of MMP-3 and microglial activation could be considered as plausible candidates for neuroprotective agents in PD. Glucagon-like peptide-1 (GLP-1), an endogenous 30-amino acid gut–brain peptide hormone, is synthesized from proglucagon

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Weiwei Xu, Jamie Morford and Franck Mauvais-Jarvis

induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival . Diabetologia 54 2067 – 2076 . ( https://doi.org/10.1007/s00125-011-2181-x ) 10.1007/s00125-011-2181-x 21567300 Lubahn DB Joseph DR Sullivan PM Willard

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Yi Zhao, Tao Liu, Nina Zhang, Fenghua Yi, Qinghua Wang, Ivan George Fantus and Tianru Jin

Introduction Pancreatic islets consist of three major types of endocrine cells, synthesizing three different peptide hormones that are important in blood glucose homeostasis. These include glucagon-producing α cells, insulin

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Benjamin J Lamont and Sofianos Andrikopoulos

Introduction The incretins glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) act via specific G-protein-coupled receptors to potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner