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Ling He Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Shumei Meng Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Emily L Germain-Lee Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Sally Radovick Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Fredric E Wondisford Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Introduction Diabetes mellitus is increasing in prevalence worldwide due to dietary excesses and sedentary lifestyles. About 25.8 million individuals in the USA have diabetes, accounting for 8.3% of the population. Type 2 diabetes previously was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0084
Volume/Issue:
Volume 221: Issue 3
Free access
Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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GLP-1R activation ( Baggio et al. 2004 ). Further, oxyntomodulin production is blunted in individuals with type 2 diabetes (T2D) ( Wewer Albrechtsen et al. 2016 ), and treatment with oxyntomodulin is beneficial for glucose homeostasis via the

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0019
Volume/Issue:
Volume 258: Issue 2
Free access
Morten Lundh Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Marco Bugliani Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Tina Dahlby Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Danny Hung-Chieh Chou Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Bridget Wagner Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

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Seyed Mojtaba Ghiasi Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Vincenzo De Tata Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Zhifei Chen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Marianne Nissan Lund Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Food Science, University of Copenhagen, Copenhagen, Denmark

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Michael J Davies Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Piero Marchetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Thomas Mandrup-Poulsen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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animal models, and our study clarifies the translational potential of this concept, in that our data in human islets do not support the use of inhibitors selective for the i-proteasome in diabetes. In conclusion, beta cells upregulate immunoproteasome

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0110
Volume/Issue:
Volume 233: Issue 3
Free access
Sara S Ellingwood Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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Alan Cheng Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This work was supported in part by the American Diabetes Association (#1-17-IBS-135 to A C). S S E was supported by the National

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0120
Volume/Issue:
Volume 238: Issue 3
Free access
Yi Lin Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

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Zhongjie Sun Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

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Introduction It is estimated that diabetes affects about 150 million people worldwide, and this figure is expected to be doubled in the next 20 years ( Zimmet et al . 2001 ). About 90–95% of all North American cases of diabetes are type 2 diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0260
Volume/Issue:
Volume 204: Issue 1
Free access
Paige V Bauer Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada
Department of Physiology, University of Toronto, Toronto, ON, Canada

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Frank A Duca Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada

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Introduction The incidence of type 2 diabetes has more than doubled since 1980, with over 382 million affected individuals worldwide, in conjunction with an increase in obesity rates and the spread of a western lifestyle ( Scully 2012 ). Given

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0056
Volume/Issue:
Volume 230: Issue 3
Free access
Jin-Bong Lee Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon Republic of Korea
Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea

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Sung-Jin Yoon Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Sang-Hyun Lee Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Moo-Seung Lee Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Haiyoung Jung Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Tae-Don Kim Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Suk Ran Yoon Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Inpyo Choi Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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Ik-Soo Kim Hanwool Life Sciences, Daejeon, Republic of Korea

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Su Wol Chung School of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, Republic of Korea

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Hee Gu Lee Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea

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Jeong-Ki Min Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea

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Young-Jun Park Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

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-α (TNF-α), which also influence insulin sensitivity ( Hofmann et al . 1994 ). Recently, many reports have examined how the phosphorylation of PPARγ is a crucial factor in modulating adipose tissue function, specifically as it relates to diabetes and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0233
Volume/Issue:
Volume 235: Issue 3
Free access
Tessa J Roseboom Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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babies who were small at birth were at increased risk of developing type 2 diabetes. Hales had found that nutritional interventions during early development affected pancreatic development and glucose tolerance. They hypothesised that poor nutrition in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0683
Volume/Issue:
Volume 242: Issue 1
Free access
Li Ding Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Yue Yin Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Lingling Han Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Yin Li Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Jing Zhao Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Weizhen Zhang Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA

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Brand Glucometer (Roche) with blood collected from the tail vein. Glucose clamp studies Two-hour hyperglycemic clamps were performed in either WT or TN mice fasted for 4 h following the instruction of National Institute of Diabetes and Digestive

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0276
Volume/Issue:
Volume 232: Issue 1
Free access
Margo P Emont Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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Hui Yu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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Jun Wu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

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.who.int/mediacentre/factsheets/fs311/en ). A number of conditions including heart disease, type 2 diabetes, and some cancers are more prevalent in obese individuals, and worldwide ∼3.4 million deaths each year are related to obesity (WHO: www.who.int/mediacentre/factsheets/fs311/en

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0026
Volume/Issue:
Volume 225: Issue 2
Free access