Search Results

You are looking at 91 - 100 of 1,638 items for :

  • Refine by access: Content accessible to me x
Clear All
Ling He Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Search for other papers by Ling He in
Google Scholar
PubMed
Close
,
Shumei Meng Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Search for other papers by Shumei Meng in
Google Scholar
PubMed
Close
,
Emily L Germain-Lee Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Search for other papers by Emily L Germain-Lee in
Google Scholar
PubMed
Close
,
Sally Radovick Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Search for other papers by Sally Radovick in
Google Scholar
PubMed
Close
, and
Fredric E Wondisford Division of Metabolism, Division of Endocrinology, Kennedy Krieger Institute, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Search for other papers by Fredric E Wondisford in
Google Scholar
PubMed
Close

Introduction Diabetes mellitus is increasing in prevalence worldwide due to dietary excesses and sedentary lifestyles. About 25.8 million individuals in the USA have diabetes, accounting for 8.3% of the population. Type 2 diabetes previously was

Free access
Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

Search for other papers by Rachel K Meyer in
Google Scholar
PubMed
Close
and
Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

Search for other papers by Frank A Duca in
Google Scholar
PubMed
Close

GLP-1R activation ( Baggio et al. 2004 ). Further, oxyntomodulin production is blunted in individuals with type 2 diabetes (T2D) ( Wewer Albrechtsen et al. 2016 ), and treatment with oxyntomodulin is beneficial for glucose homeostasis via the

Free access
Morten Lundh Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

Search for other papers by Morten Lundh in
Google Scholar
PubMed
Close
,
Marco Bugliani Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Search for other papers by Marco Bugliani in
Google Scholar
PubMed
Close
,
Tina Dahlby Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Tina Dahlby in
Google Scholar
PubMed
Close
,
Danny Hung-Chieh Chou Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

Search for other papers by Danny Hung-Chieh Chou in
Google Scholar
PubMed
Close
,
Bridget Wagner Chemical Biology and Therapeutics Program, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA

Search for other papers by Bridget Wagner in
Google Scholar
PubMed
Close
,
Seyed Mojtaba Ghiasi Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Seyed Mojtaba Ghiasi in
Google Scholar
PubMed
Close
,
Vincenzo De Tata Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Vincenzo De Tata in
Google Scholar
PubMed
Close
,
Zhifei Chen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Zhifei Chen in
Google Scholar
PubMed
Close
,
Marianne Nissan Lund Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Food Science, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Marianne Nissan Lund in
Google Scholar
PubMed
Close
,
Michael J Davies Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Michael J Davies in
Google Scholar
PubMed
Close
,
Piero Marchetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Search for other papers by Piero Marchetti in
Google Scholar
PubMed
Close
, and
Thomas Mandrup-Poulsen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Thomas Mandrup-Poulsen in
Google Scholar
PubMed
Close

animal models, and our study clarifies the translational potential of this concept, in that our data in human islets do not support the use of inhibitors selective for the i-proteasome in diabetes. In conclusion, beta cells upregulate immunoproteasome

Free access
Sara S Ellingwood Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

Search for other papers by Sara S Ellingwood in
Google Scholar
PubMed
Close
and
Alan Cheng Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

Search for other papers by Alan Cheng in
Google Scholar
PubMed
Close

there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding This work was supported in part by the American Diabetes Association (#1-17-IBS-135 to A C). S S E was supported by the National

Free access
Yi Lin Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

Search for other papers by Yi Lin in
Google Scholar
PubMed
Close
and
Zhongjie Sun Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center (OUHSC), BMSB 662A, PO Box 26901, 940 SL Young Boulevard, Oklahoma City, Oklahoma 73104, USA

Search for other papers by Zhongjie Sun in
Google Scholar
PubMed
Close

Introduction It is estimated that diabetes affects about 150 million people worldwide, and this figure is expected to be doubled in the next 20 years ( Zimmet et al . 2001 ). About 90–95% of all North American cases of diabetes are type 2 diabetes

Free access
Paige V Bauer Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada
Department of Physiology, University of Toronto, Toronto, ON, Canada

Search for other papers by Paige V Bauer in
Google Scholar
PubMed
Close
and
Frank A Duca Toronto General Hospital Research Institute and Department of Medicine, UHN, Toronto, ON, Canada

Search for other papers by Frank A Duca in
Google Scholar
PubMed
Close

Introduction The incidence of type 2 diabetes has more than doubled since 1980, with over 382 million affected individuals worldwide, in conjunction with an increase in obesity rates and the spread of a western lifestyle ( Scully 2012 ). Given

Free access
Jin-Bong Lee Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon Republic of Korea
Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea

Search for other papers by Jin-Bong Lee in
Google Scholar
PubMed
Close
,
Sung-Jin Yoon Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Sung-Jin Yoon in
Google Scholar
PubMed
Close
,
Sang-Hyun Lee Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Sang-Hyun Lee in
Google Scholar
PubMed
Close
,
Moo-Seung Lee Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Moo-Seung Lee in
Google Scholar
PubMed
Close
,
Haiyoung Jung Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Haiyoung Jung in
Google Scholar
PubMed
Close
,
Tae-Don Kim Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Tae-Don Kim in
Google Scholar
PubMed
Close
,
Suk Ran Yoon Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Suk Ran Yoon in
Google Scholar
PubMed
Close
,
Inpyo Choi Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Inpyo Choi in
Google Scholar
PubMed
Close
,
Ik-Soo Kim Hanwool Life Sciences, Daejeon, Republic of Korea

Search for other papers by Ik-Soo Kim in
Google Scholar
PubMed
Close
,
Su Wol Chung School of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, Republic of Korea

Search for other papers by Su Wol Chung in
Google Scholar
PubMed
Close
,
Hee Gu Lee Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea

Search for other papers by Hee Gu Lee in
Google Scholar
PubMed
Close
,
Jeong-Ki Min Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea

Search for other papers by Jeong-Ki Min in
Google Scholar
PubMed
Close
, and
Young-Jun Park Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon Republic of Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Search for other papers by Young-Jun Park in
Google Scholar
PubMed
Close

-α (TNF-α), which also influence insulin sensitivity ( Hofmann et al . 1994 ). Recently, many reports have examined how the phosphorylation of PPARγ is a crucial factor in modulating adipose tissue function, specifically as it relates to diabetes and

Free access
Tessa J Roseboom Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Reproduction and Development, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

Search for other papers by Tessa J Roseboom in
Google Scholar
PubMed
Close

babies who were small at birth were at increased risk of developing type 2 diabetes. Hales had found that nutritional interventions during early development affected pancreatic development and glucose tolerance. They hypothesised that poor nutrition in

Free access
Li Ding Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Search for other papers by Li Ding in
Google Scholar
PubMed
Close
,
Yue Yin Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Search for other papers by Yue Yin in
Google Scholar
PubMed
Close
,
Lingling Han Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Search for other papers by Lingling Han in
Google Scholar
PubMed
Close
,
Yin Li Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Search for other papers by Yin Li in
Google Scholar
PubMed
Close
,
Jing Zhao Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Search for other papers by Jing Zhao in
Google Scholar
PubMed
Close
, and
Weizhen Zhang Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA

Search for other papers by Weizhen Zhang in
Google Scholar
PubMed
Close

Brand Glucometer (Roche) with blood collected from the tail vein. Glucose clamp studies Two-hour hyperglycemic clamps were performed in either WT or TN mice fasted for 4 h following the instruction of National Institute of Diabetes and Digestive

Free access
Jon G Mabley
Search for other papers by Jon G Mabley in
Google Scholar
PubMed
Close
,
Pal Pacher School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by Pal Pacher in
Google Scholar
PubMed
Close
,
Kanneganti G K Murthy School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by Kanneganti G K Murthy in
Google Scholar
PubMed
Close
,
William Williams School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by William Williams in
Google Scholar
PubMed
Close
,
Garry J Southan School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by Garry J Southan in
Google Scholar
PubMed
Close
,
Andrew L Salzman School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by Andrew L Salzman in
Google Scholar
PubMed
Close
, and
Csaba Szabo School of Pharmacy and Biomolecular Sciences, Section on Oxidative Stress Tissue Injury,, Inotek Pharmaceuticals Corporation,, Department of Surgery, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK

Search for other papers by Csaba Szabo in
Google Scholar
PubMed
Close

Introduction Type I diabetes is a disease characterized by the specific destruction of insulin-producing β-cells in the pancreatic islets of Langerhans by the immune system ( Bach 1994 ). Immune cells, particularly macrophages and T-cells, invade

Free access