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Graham W Aberdeen Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Jeffery S Babischkin Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Mediation by M 3 -muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat . British Journal of Pharmacology 112 519 – 524 . ( https://doi.org/10.1111/j.1476

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G Basini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S Bussolati Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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S E Santini Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Bianchi Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Careri Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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A Mangia Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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M Musci Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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F Grasselli Dipartimento di Produzioni Animali, Dipartimento di Chimica Generale ed Inorganica, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria

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-hydroxyestrogens in polycystic ovary syndrome . Journal of Clinical Endocrinology and Metabolism 92 3285 – 3291 . Sato Y 2006 Update on endogenous inhibitors of angiogenesis . Endothelium 13 147 – 155 . Shelhamer JH Volkman DJ Parrillo JE

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Cintia B Ueta Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil
Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Gustavo W Fernandes Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Luciane P Capelo Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Tatiane L Fonseca Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Flávia D'Angelo Maculan Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Cecilia H A Gouveia Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Patrícia C Brum Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Marcelo A Christoffolete Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Marcelo S Aoki Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Carmen L Lancellotti Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Brian Kim Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Antonio C Bianco Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Miriam O Ribeiro Centro de Ciências Biológicas e da Saúde, Department of Cell and Developmental Biology, School of Arts, Natural and Humans Science Center, Department of Anatomy, Division of Endocrinology, School of Physical Education and Sport, AFIP and Pathology, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1° Andar, 01302-907 São Paulo, Brazil

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Therapeutics 261 638 – 642 . Huang Y Kwok KH Chan NW Lau CW Chen ZY 1998 Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery . Clinical and Experimental Pharmacology & Physiology 25 405 – 411

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E Louiset INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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V Contesse INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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L Groussin INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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D Cartier INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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C Duparc INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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V Perraudin INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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J Bertherat INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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H Lefebvre INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France
INSERM U413, INSERM U567, Department of Endocrinology, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France

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impartiality of this scientific work. References Aldasoro M Medina P Vila JM Otero E Martinez-Leon JB Lluch S 1997 Endothelium-dependent relaxation of human saphenous veins in response to vasopressin and desmopressin . Journal of Vascular Surgery

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Constanze Hantel
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Felicitas Lewrick Endocrine Research Unit, Department of Pharmaceutical Technology and Biopharmacy, Medizinische Klinik and Poliklinik IV, Ludwig‐Maximilians‐University, Ziemssenstraße 1, D-80336 Munich, Germany

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Martin Reincke
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Regine Süss Endocrine Research Unit, Department of Pharmaceutical Technology and Biopharmacy, Medizinische Klinik and Poliklinik IV, Ludwig‐Maximilians‐University, Ziemssenstraße 1, D-80336 Munich, Germany

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Felix Beuschlein
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toxicity based on the modified biodistribution of the drug ( Gabizon et al . 1982 ). The relatively large size of liposomal carriers (45–200 nm) prevents them from passing through the 2 nm pores found in the endothelium of blood vessels in most healthy

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Anna Cinkajzlová Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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, reduces the expression of insulin-regulated glucose transporter type 4 located in adipocytes and skeletal and cardiac muscles TNFα : involved in atherosclerosis progression, stimulates interaction between leukocytes and the endothelium through

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S Ramaswamy
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C R Pohl
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G R Marshall
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T M Plant
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through the vascular endothelium. Journal of Endocrinology 145 1 –9. Gnessi L , Fabri A & Spera G 1997 Gonadal peptides as mediators of development and functional control of the testis: An integrated system with hormones

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Omer Turker Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Kamil Kumanlioglu Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Inanc Karapolat Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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Ismail Dogan Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey
Department of Nuclear Medicine, Faculty of Medicine, Ege University, Izmir, Turkey
Department of Nuclear Medicine, Sifa Hospital, Izmir, Turkey

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. Selenoprotein P is the Se transport protein and is an antioxidant on endothelium. The other types of selenoproteins are defined as H, I, K, M, N, O, R, S, T, and V, and most of their functions are still unknown ( Beckett & Arthur 2005 ). In Turkey, there

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Abby J Sarkar Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Kirti Chaturvedi Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Cui Ping Chen Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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Dipak K Sarkar Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA

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antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. Journal of Clinical Pathology 43 752 –757. Relf M , LeJeune S & Scott PA 1997 Expression of the angiogenic factors

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M Zerani Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Boiti Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Dall’Aglio Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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L Pascucci Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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M Maranesi Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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G Brecchia Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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C Mariottini Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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G Guelfi Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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D Zampini Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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A Gobbetti Dipartimento di Biologia Molecolare, Cellulare e Animale, Università di Camerino, via F Camerini 1, 62032 Camerino, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Laboratorio di Biotecnologie Fisiologiche, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy
Dipartimento di Scienze Biopatologiche Veterinarie, Sezione di Anatomia, Università di Perugia, S Costanzo 4, 06100 Perugia, Italy

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–339. Kimura K , Tsuda K, Baba A, Kawabe T, Bohoka S, Ibata M, Moriwaki C, Hano T & Nishio I 2000 Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochemical and Biophysical Research

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