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Dominique A Glauser and Werner Schlegel

, glucagon-like peptide-1 (GLP-1), or glucose-dependent insulinotropic polypeptide (GIP) ( Trumper et al. 2000 , 2001 , Wrede et al. 2002 , Buteau et al. 2006 ). The binding of IGF-I or insulin to their receptors results in the

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Flávia Maria Silva-Veiga, Carolline Santos Miranda, Fabiane Ferreira Martins, Julio Beltrame Daleprane, Carlos Alberto Mandarim-de-Lacerda, and Vanessa Souza-Mello

inhibitor of dipeptidyl peptidase-4 (DPP-4) that suppresses the rapid degradation of the glucagon-like peptide-1 (GLP-1), a gastrointestinal hormone (incretin) that increases glucose-dependent insulin secretion. DPP-4 inhibitors decrease GLP-1 degradation

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Cho-Rong Bae, Kazuya Hasegawa, Sayaka Akieda-Asai, Yurie Kawasaki, Kazuyo Senba, Youn-Soo Cha, and Yukari Date

in the stomach 5 and 10 h after feeding. We monitored plasma levels of the satiety signals cholecystokinin (CCK), glucagon-like peptide 1 (GLP1), and peptide YY (PYY), as well as the levels of glucose and insulin at pre-, mid-, and post-feeding. We

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Takaharu Maruyama, Kenichi Tanaka, Jun Suzuki, Hiroyuki Miyoshi, Naomoto Harada, Takao Nakamura, Yasuhisa Miyamoto, Akio Kanatani, and Yoshitaka Tamai

). It was also reported that bile acid stimulated glucagon-like peptide-1 (GLP-1) secretion from STC-1 cells via Gpbar1/TGR5 ( Katsuma et al. 2005 ). GLP-1 is secreted from the L-cells in the intestine after meals and indirectly decreases blood glucose

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Xinrong Zhou, Bangguo Qian, Ning Ji, Conghui Lui, Zhiyuan Liu, Bing Li, Huarong Zhou, and Caifeng Yan

, 30, 60, and 120 min after glucose administration. One week later, OGTT were repeated with the same glucose load. Blood (0.75 ml) was drawn by eye bleed at 0 and 30 min. For measurement of c-peptide, total glucagon like peptide-1 (GLP-1), and total

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Libor Vítek and Martin Haluzík

) CAR Liver Lipid and glucose metabolism Maglich et al . (2009) and Gao et al . (2009) Cytoplasmic receptors TGR5 Intestine Induction of GLP-1 secretion Parker et al . (2012) Brown adipose tissue/skeletal muscles Energy expenditure via activation of

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Yoon Sin Oh, Youn-Jung Lee, Yup Kang, Jaeseok Han, Oh-Kyung Lim, and Hee-Sook Jun

-1 (GLP1), a potent gluco-incretin hormone, has an antidiabetic function. It enhances glucose-dependent insulin release, insulin biosynthesis, and β-cell proliferation and suppresses β-cell apoptosis ( Doyle & Egan 2007 ). Exendin-4, a GLP1 receptor

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Ivan Quesada, Eva Tudurí, Cristina Ripoll, and Ángel Nadal

-induced inhibition of glucagon release. Figure 3 Paracrine signalling in the α-cell. See text for details. ADCY, adenylate cyclase; AMPA-R, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; GABA, γ-aminobutyric acid; GLP1, glucagon-like peptide-1; GRM

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Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze, and Jaroslav Kuneš

periphery, leptin increases expression of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and cholecystokinin (CCK) produced by intestine. In the brain centers connected to food intake regulation which are solitary tract

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Yasushi Kirino, Youichi Sato, Takayuki Kamimoto, Kazuyoshi Kawazoe, Kazuo Minakuchi, and Yutaka Nakahori

the penultimate L -proline or L -alanine at the N-terminus of several polypeptides, such as glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP; De Meester et al . 2000 ). The major incretin hormones, GLP1 and GIP