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Jay W Porter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Joe L Rowles III Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

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Justin A Fletcher Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Research Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Terese M Zidon Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Nathan C Winn Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Leighton T McCabe Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Young-Min Park Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
University of Colorado Denver – Anschutz Medical Campus, Denver, Colorado, USA

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James W Perfield II Lilly Research Laboratories, Indianapolis, Indiana, USA

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John P Thyfault Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
Kansas City VA Medical Center, Kansas City, Missouri, USA

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R Scott Rector Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Research Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Department of Child Health, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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adaptations are not completely understood. Fibroblast growth factor 21 (FGF21), a pleotropic endocrine hormone produced by several tissues, plays an important role in systemic glucose and lipid metabolism ( Kharitonenkov et al . 2005 , Zhang et al . 2008

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Henrik Oster Institute of Neurobiology, University of Lübeck, Lübeck, Germany

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repertoire ( Timmermans et al. 2019 ). This GC-mediated response takes minutes to hours to complete, making it less suited for fight-or-flight responses, but rather for intermediate-term adaptations to a stressful environment. Both response systems share

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Anjara Rabearivony School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China

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Huan Li School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China

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Shiyao Zhang School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China

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Siyu Chen School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China

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Xiaofei An Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

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Chang Liu School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China

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all the physiological processes affected by environmental temperature, the circadian clock might be the most representative, which plays an important role in the adaptation to external cues. Daily cycles of light and temperature are the most reliable

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Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Ian Bloor Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Reham Alagal Department of Physical Sport Science, Princess Nourah Bint AbdulRahman University, Riyadh, Saudi Arabia

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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than any other organ in the body ( Symonds 2013 ). A major factor determining energy balance and thus the relative amounts of brown, beige or white adipose is ambient temperature, an adaptation that may be recruited from the first appearance of

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M G Gnanalingham Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK

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A Mostyn Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK

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D S Gardner Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK

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T Stephenson Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK

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M E Symonds Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK

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concentrations, in the fetal lung of umbilical cord compression fetuses ( Gnanalingham et al. 2005 b ). These parallel changes in the mitochondria within fetal lung may better prepare the compromised fetus for preterm birth and extrauterine adaptation by

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David R Grattan Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand

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, rendering the short-loop negative feedback system functionally inactive ( Grattan & Averill 1995 , Fliestra & Voogt 1997 ). This adaptation persists into lactation, and dopamine secretion remains low throughout this period of elevated prolactin secretion

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Michael Wallis Biochemistry Department, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9QG, UK

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the process of function switching ( Wallis 1997 , Forsyth & Wallis 2002 ). If prolactin acquired a second function, the importance of which fluctuated over time, each switch (fluctuation) would lead to adaptation and additional substitutions. Repeated

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M Jankowski Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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D Wang Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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S Mukaddam-Daher Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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J Gutkowska Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l’Université de Montreal (CHUM) Montreal, Quebec, Canada

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Introduction In the rat, maternal cardiovascular adaptation to pregnancy is initiated 2 days after implantation and is manifested by expanded stroke volume as well as increased heart contractility ( Slangen et al. 1997 ). In effect

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S Pearce
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H Budge
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A Mostyn
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E Genever
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R Webb
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P Ingleton
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A M Walker
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M E Symonds
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T Stephenson
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attest to the specificity of staining during the immunoblotting procedure. Furthermore, these adaptations occurred despite no change in total plasma membrane protein in adipose tissue with postnatal age (data not shown). Therefore, although there is an

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Christian K Tipsmark Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

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Steffen S Madsen Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

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) families . Aquaculture 272 625 – 635 . Madsen SS 1990 The role of cortisol and growth hormone in seawater adaptation and development of hypoosmoregulatory mechanisms in sea trout parr ( Salmo trutta trutta ) . General and Comparative

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