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-responsive elements in gene promoters ( Marzolla et al. 2017 ), interaction between MR and other transcription factors such as NFkB and AP-1 ( Fiebeler et al. 2001 ), non-genomic activation of signaling pathways that impinge on gene regulation, and suppression of
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.1242/jcs.088500 ) Featherstone K White MRH Davis JRE 2012 The prolactin gene: a paradigm of tissue-specific gene regulation with complex temporal transcription dynamics . Journal of Neuroendocrinology 24 977 – 990 . ( doi:10.1111/j.1365
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regulated by gene regulation networks and epigenetic control, are also of great importance. Consequently, study of variations in levels of RNA transcripts has also been applied to identify new molecular mechanisms and signalling pathways involved in
Graduate School for Biomedical Science and Engineering, University of Maine, Orono, Maine, USA
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
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2013 Genomic imprinting of the type 3 thyroid hormone deiodinase gene: regulation and developmental implications . Biochimica et Biophysica Acta 1830 3946 – 3955 . ( https://doi.org/10.1016/j.bbagen.2012.03.015 ) Chatonnet F Livera G Fumel
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hormonal treatment, they were washed twice with 1× PBS and cultured in an oestrogen-depleted medium: phenol red-free DMEM-F12 medium with 10% charcoal-stripped FBS (Wisent) and 50 μg/ml penicillin–streptomycin, for 24 h. For gene regulation studies in MCF-7
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et al . 2018 ). Dynamic changes in gene regulation with age are rarely examined but do enable the identification of important regulatory relationships. These will have crucial depot-specific roles to enable differentiation and the adaptation necessary
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412 179 – 190 . ( https://doi.org/10.1042/BJ20080281 ) 10.1042/BJ20080281 Iype T Francis J Garmey JC Schisler JC Nesher R Weir GC Becker TC Newgard CB Griffen SC Mirmira RG 2005 Mechanism of insulin gene regulation by the
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activity) and that results in a male and female differential endocrine susceptibility and gene regulation, particularly in sex steroid-responsive genes. The relevance of oestrogen programming mechanisms within the mammalian foetus and perinatal time period
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FM Johren O Raasch W 2012 Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARgamma target gene regulation . Endocrinology 153 1103 – 1115 . ( https://doi.org/10.1210/en.2011-0183 ) 22253423 10
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.09.001 ) 28969926 10.1016/j.tins.2017.09.001 Mitchner NA Garlick C Ben Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland . Endocrinology 139 3976 – 3983 . ( https://doi.org/10