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Jennifer J DuPont Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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Iris Z Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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-responsive elements in gene promoters ( Marzolla et al. 2017 ), interaction between MR and other transcription factors such as NFkB and AP-1 ( Fiebeler et al. 2001 ), non-genomic activation of signaling pathways that impinge on gene regulation, and suppression of

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Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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.1242/jcs.088500 ) Featherstone K White MRH Davis JRE 2012 The prolactin gene: a paradigm of tissue-specific gene regulation with complex temporal transcription dynamics . Journal of Neuroendocrinology 24 977 – 990 . ( doi:10.1111/j.1365

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Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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regulated by gene regulation networks and epigenetic control, are also of great importance. Consequently, study of variations in levels of RNA transcripts has also been applied to identify new molecular mechanisms and signalling pathways involved in

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Arturo Hernandez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA
Graduate School for Biomedical Science and Engineering, University of Maine, Orono, Maine, USA
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA

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M Elena Martinez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA

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2013 Genomic imprinting of the type 3 thyroid hormone deiodinase gene: regulation and developmental implications . Biochimica et Biophysica Acta 1830 3946 – 3955 . ( https://doi.org/10.1016/j.bbagen.2012.03.015 ) Chatonnet F Livera G Fumel

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Sanda Raulic London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Yudith Ramos-Valdes London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Gabriel E DiMattia London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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hormonal treatment, they were washed twice with 1× PBS and cultured in an oestrogen-depleted medium: phenol red-free DMEM-F12 medium with 10% charcoal-stripped FBS (Wisent) and 50 μg/ml penicillin–streptomycin, for 24 h. For gene regulation studies in MCF-7

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Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Peter Aldiss Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Neele Dellschaft Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Hernan P Fainberg Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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Harold Sacks VA Endocrinology and Diabetes Division, VA Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK

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et al . 2018 ). Dynamic changes in gene regulation with age are rarely examined but do enable the identification of important regulatory relationships. These will have crucial depot-specific roles to enable differentiation and the adaptation necessary

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Juan Sun Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Liqun Mao Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Hongyan Yang Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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Decheng Ren Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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412 179 – 190 . ( https://doi.org/10.1042/BJ20080281 ) 10.1042/BJ20080281 Iype T Francis J Garmey JC Schisler JC Nesher R Weir GC Becker TC Newgard CB Griffen SC Mirmira RG 2005 Mechanism of insulin gene regulation by the

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Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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activity) and that results in a male and female differential endocrine susceptibility and gene regulation, particularly in sex steroid-responsive genes. The relevance of oestrogen programming mechanisms within the mammalian foetus and perinatal time period

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Viktorija Gustaityte Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Martina Winkler Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Ines Stölting Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Walter Raasch Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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FM Johren O Raasch W 2012 Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARgamma target gene regulation . Endocrinology 153 1103 – 1115 . ( https://doi.org/10.1210/en.2011-0183 ) 22253423 10

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María Andrea Camilletti Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Alejandra Abeledo-Machado Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Jimena Ferraris Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Pablo A Pérez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Erika Y Faraoni Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Daniel Pisera Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Silvina Gutierrez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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.09.001 ) 28969926 10.1016/j.tins.2017.09.001 Mitchner NA Garlick C Ben Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland . Endocrinology 139 3976 – 3983 . ( https://doi.org/10

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