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Robson A S Santos Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Anderson J Ferreira Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Thiago Verano-Braga Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Michael Bader Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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, angiotensin. Figure 3 Phenotypic changes observed in mice with gene-targeted deletion of Mas. In this review, we will briefly highlight recent findings concerning the cardiovascular, renal, and metabolic roles of the ACE2/Ang-(1–7)/Mas axis. Furthermore, we

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Sanda Raulic London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Yudith Ramos-Valdes London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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Gabriel E DiMattia London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of
London Regional Cancer Program, Biochemistry, 790 Commissioners Road, Room A4-921, London, Ontario, N6A 4L6 Canada Departments of

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steroid receptor function by gene targeting in mice . Journal of Steroid Biochemistsry and Molecular Biology 93 107 – 112 . Xu Z Stokoe D Kane LP Weiss A 2002 The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and

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Yanwen Jiang College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Lu Chen College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Robert N Taylor Departments of Obstetrics and Gynecology and Molecular Medicine and Translational Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

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Chunjin Li College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Xu Zhou College of Animal Sciences, Jilin University, Changchun, Jilin, China

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-selective and conditional gene targeting approaches is necessary to better understand the role of these enzymes during the ovarian cycle and gestation. As previously mentioned, excess RA concentration is harmful to decidualization and implantation. Thus, actual

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K J Oldknow Developmental Biology, The Roslin Institute, Edinburgh, UK

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V E MacRae Developmental Biology, The Roslin Institute, Edinburgh, UK

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C Farquharson Developmental Biology, The Roslin Institute, Edinburgh, UK

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ceramide-generating neutral sphingomyelinase 2 enzyme (nSMase2/SMPD3 – gene-targeted Smpd3 −/− and fro/fro mice) display gross skeletal abnormalities, including deformed long bones, short-limb dwarfism, hypomineralisation, delayed dentin mineralisation

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Esther Isorna Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Nuria de Pedro Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Ana I Valenciano Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Ángel L Alonso-Gómez Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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María J Delgado Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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152 1347 – 1354 . ( doi:10.1210/en.2010-1068 ) Appelbaum L Vallone D Anzulovich A Ziv L Tom M Foulkes NS Gothilf Y 2006 Zebrafish arylalkylamine-N-acetyltranferase genes–targets for regulation of the circadian clock

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Daniel M Kelly Department of Human Metabolism, Robert Hague Centre for Diabetes and Endocrinology, Medical School, The University of Sheffield, Sheffield S10 2RX, UK

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T Hugh Jones Department of Human Metabolism, Robert Hague Centre for Diabetes and Endocrinology, Medical School, The University of Sheffield, Sheffield S10 2RX, UK
Department of Human Metabolism, Robert Hague Centre for Diabetes and Endocrinology, Medical School, The University of Sheffield, Sheffield S10 2RX, UK

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). This study additionally described the inhibition of nuclear factor κB (NFκB) activation, not only as a potential mechanism for decreased VCAM-1 expression, but also as a prospective modulator of several other inflammatory gene targets known to be

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David R Grattan Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand

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function, including gene-targeting approaches that allow conditional regulation of prolactin responsive cells, will provide the impetus for a new wave of research to enhance our understanding of this fascinating system. Sixty years on from Geoffrey Harris

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Vimal Selvaraj Department of Animal Science, Cornell University, Ithaca, New York, USA

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Lan N Tu Department of Animal Science, Cornell University, Ithaca, New York, USA

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. 2015 ). In 2015, use of the same MA-10 Leydig cells made deficient in TSPO by CRISPR/Cas9-mediated gene targeting indicated that PK11195 could stimulate steroidogenesis even in the absence of TSPO ( Tu et al . 2015 ). This work performed using three

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K A Walters School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia
Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia

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V Rodriguez Paris School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia

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A Aflatounian School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia

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D J Handelsman Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia

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randomized controlled trial . European Journal of Obstetrics, Gynecology, and Reproductive Biology 200 . ( https://doi.org/10.1016/j.ejogrb.2016.02.009 ) 26963897 Kuhn R Torres RM 2002 Cre/loxP recombination system and gene targeting . Methods

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Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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Endocrinology 52 11 – 28 . ( https://doi.org/10.1530/JME-13-0106 ) 24049066 Martinez-Sanchez A Nguyen-Tu MS Rutter GA 2015 DICER inactivation identifies pancreatic beta-cell “disallowed” genes targeted by microRNAs . Molecular Endocrinology

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