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Elena Maneschi, Annamaria Morelli, Sandra Filippi, Ilaria Cellai, Paolo Comeglio, Benedetta Mazzanti, Tommaso Mello, Alessandra Calcagno, Erica Sarchielli, Linda Vignozzi, Farid Saad, Roberto Vettor, Gabriella B Vannelli, and Mario Maggi

and obesity and testosterone treatment of hypogonadal patients improves insulin sensitivity and reduces fat mass ( Corona et al . 2011 a ). Despite this evidence, the pathogenetic link and the clinical significance of MetS-associated male hypogonadism

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Salvatore P Mangiafico, Shueh H Lim, Sandra Neoh, Helene Massinet, Christos N Joannides, Joseph Proietto, Sofianos Andrikopoulos, and Barbara C Fam

insulin sensitivity in young and adult PEPCK transgenic and Piebald Virol Glaxo (PVG/c) control rats. The results showed that a primary increase in glucose production did not lead to glucose intolerance, due to normal hepatic and peripheral insulin

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A Corbould

Introduction Adipose tissue is now recognized to play a central role in determining whole body insulin sensitivity ( Minokoshi et al. 2003 ). In animal models, insulin resistance in adipose tissue secondarily results in insulin

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Monique C Saleh, Michael B Wheeler, and Catherine B Chan

determine if the age-related changes in glucose tolerance (as measured by the ins:gluc ratio, Table 1 ) of ob/ob mice were related to changes in tissue insulin sensitivity. The 16-week-old lean mice were more sensitive to insulin than ob/ob mice in any

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Shin-Ichi Kato, Katsuyoshi Sato, Haruka Chida, Sang-Gun Roh, Shyuichi Ohwada, Shusuke Sato, Paul Guilloteau, and Kazuo Katoh

insulin sensitivity. In veal calves, milk feeding for a long period was demonstrated to cause insulin resistance. The responses of plasma glucose and insulin to a MF ingestion in calves became greater by aging and remained elevated for more than 6 h after

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Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, and Mary E Wlodek

rats born small due to uteroplacental insufficiency, although confounded by obesity, pregnancy unmasked maternal diabetes that led to macrosomic F2 offspring with increased adiposity, impaired glucose tolerance, and reduced insulin sensitivity ( Boloker

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Gulizar Issa Ameen and Silvia Mora

acid oxidation in skeletal muscle and whole-body insulin sensitivity ( Molero et al . 2004 ). These mice have also exhibited resistance to the deleterious effects of a high-fat diet ( Molero et al . 2006 ). White adipose tissue (WAT) has an

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Sarah L Craig, Victor A Gault, Gerd Hamscher, and Nigel Irwin

glucose, insulin, GIP and GLP-1, as well as glucose and pyruvate tolerance, peripheral insulin sensitivity, expression of key genes involved in liver glucose metabolism and insulin action, as well as DPP-4 activity and pancreatic islet morphology were

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Clare M Reynolds and Mark H Vickers

). Adiponectin Adiponectin modulates a number of metabolic processes, including fatty acid oxidation and glucose homeostasis with a reduced adiponectin expression commonly associated with impaired insulin sensitivity in animal models ( Diez & Iglesias 2003

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M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu, and E W Kraegen

adiponectin to increase both fatty acid oxidation and glucose disposal into skeletal muscle ( Yamauchi et al . 2002 , Yoon et al . 2006 ) and additionally to improve insulin sensitivity ( Yamauchi et al . 2001 ) has been proposed, effects that have been