Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 101 - 110 of 1,638 items for :

  • Refine by access: Content accessible to me x
Clear All
Margo P Emont Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

Search for other papers by Margo P Emont in
Google Scholar
PubMed Close
,
Hui Yu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

Search for other papers by Hui Yu in
Google Scholar
PubMed Close
, and
Jun Wu Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA
Life Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA

Search for other papers by Jun Wu in
Google Scholar
PubMed Close

.who.int/mediacentre/factsheets/fs311/en ). A number of conditions including heart disease, type 2 diabetes, and some cancers are more prevalent in obese individuals, and worldwide ∼3.4 million deaths each year are related to obesity (WHO: www.who.int/mediacentre/factsheets/fs311/en

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0026
Volume/Issue:
Volume 225: Issue 2
Free access
Anna Krook Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, SE-171 77 Stockholm, Sweden

Search for other papers by Anna Krook in
Google Scholar
PubMed Close

Peripheral insulin resistance is characteristic not only for subjects with type 2 diabetes, but a clinically relevant finding also in subjects with type 1 diabetes ( Yki-Järvinen et al . 1987 , Rossetti et al . 1990 , Bingley et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0263
Volume/Issue:
Volume 211: Issue 1
Free access
M Fraenkel Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

Search for other papers by M Fraenkel in
Google Scholar
PubMed Close
,
J Caloyeras Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

Search for other papers by J Caloyeras in
Google Scholar
PubMed Close
,
S-G Ren Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

Search for other papers by S-G Ren in
Google Scholar
PubMed Close
, and
S Melmed Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

Search for other papers by S Melmed in
Google Scholar
PubMed Close

-cell proliferation and an inability to expand islet cell mass with aging. Diabetes onset is accompanied by loss of fat tissue. In contrast, pttg −/− female mice rarely develop diabetes before 1 year of age and the incidence of diabetes in older pttg -null females

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06656
Volume/Issue:
Volume 189: Issue 3
Free access
Yoko Yagishita Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Yoko Yagishita in
Google Scholar
PubMed Close
,
Akira Uruno Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

Search for other papers by Akira Uruno in
Google Scholar
PubMed Close
,
Dionysios V Chartoumpekis Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Dionysios V Chartoumpekis in
Google Scholar
PubMed Close
,
Thomas W Kensler Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Thomas W Kensler in
Google Scholar
PubMed Close
, and
Masayuki Yamamoto Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
Tohoku Medical-Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

Search for other papers by Masayuki Yamamoto in
Google Scholar
PubMed Close

Introduction Type 1 diabetes is caused by destruction or dysfunction of insulin-producing pancreatic β-cells, and its incidence is increasing in the modern world ( Tuomilehto 2013 ). Protecting β-cells from inflammation and destruction is an

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0355
Volume/Issue:
Volume 240: Issue 3
Free access
Bethany P Cummings
Search for other papers by Bethany P Cummings in
Google Scholar
PubMed Close
,
Ahmed Bettaieb Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

Search for other papers by Ahmed Bettaieb in
Google Scholar
PubMed Close
,
James L Graham Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

Search for other papers by James L Graham in
Google Scholar
PubMed Close
,
Kimber Stanhope Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

Search for other papers by Kimber Stanhope in
Google Scholar
PubMed Close
,
Fawaz G Haj Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

Search for other papers by Fawaz G Haj in
Google Scholar
PubMed Close
, and
Peter J Havel Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

Search for other papers by Peter J Havel in
Google Scholar
PubMed Close

Introduction The prevalence of type 2 diabetes is steadily rising with approximately one in ten adults affected in industrialized countries ( Danaei et al . 2011 ), necessitating the advent of more effective therapeutic strategies for the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0601
Volume/Issue:
Volume 221: Issue 1
Free access
Chun Zeng Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Chun Zeng in
Google Scholar
PubMed Close
,
Xin Yi Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Xin Yi in
Google Scholar
PubMed Close
,
Danny Zipris Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Danny Zipris in
Google Scholar
PubMed Close
,
Hongli Liu Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Hongli Liu in
Google Scholar
PubMed Close
,
Lin Zhang Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Lin Zhang in
Google Scholar
PubMed Close
,
Qiaoyun Zheng Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Qiaoyun Zheng in
Google Scholar
PubMed Close
,
Krishnamurthy Malathi Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Krishnamurthy Malathi in
Google Scholar
PubMed Close
,
Ge Jin Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Ge Jin in
Google Scholar
PubMed Close
, and
Aimin Zhou Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA
Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA
Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

Search for other papers by Aimin Zhou in
Google Scholar
PubMed Close

Introduction The etiology of diabetes continues to be a focus of investigation. Both genetic and environmental factors such as toxins, viruses, and diets are believed to play an important role in its pathogenesis ( Mathis et al . 2001 ). A

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0509
Volume/Issue:
Volume 223: Issue 3
Free access
Rosalia C M Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Rosalia C M Simmen in
Google Scholar
PubMed Close
,
Dustin M Brown Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Dustin M Brown in
Google Scholar
PubMed Close
,
Charles M Quick Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Charles M Quick in
Google Scholar
PubMed Close
,
Iad Alhallak Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Iad Alhallak in
Google Scholar
PubMed Close
,
Tyler Rose Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Tyler Rose in
Google Scholar
PubMed Close
,
Shi J Liu Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Search for other papers by Shi J Liu in
Google Scholar
PubMed Close
, and
Angela S Kelley Department of Obstetrics and Gynecology, The University of Michigan Health System, Ann Arbor, Michigan, USA

Search for other papers by Angela S Kelley in
Google Scholar
PubMed Close

Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disease, resulting from the destruction of insulin-producing β-cells of the pancreatic islets of Langerhans, which leads to a state of hypoinsulinemia and hyperglycemia. In 2015, 1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0248
Volume/Issue:
Volume 243: Issue 3
Free access
Bernadette M Trojanowski Institute of Physiological Chemistry, Ulm University, Ulm, Germany

Search for other papers by Bernadette M Trojanowski in
Google Scholar
PubMed Close
,
Heba H Salem Faculty of Pharmacy, Cairo University, Cairo, Egypt
Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

Search for other papers by Heba H Salem in
Google Scholar
PubMed Close
,
Heike Neubauer Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

Search for other papers by Heike Neubauer in
Google Scholar
PubMed Close
,
Eric Simon Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

Search for other papers by Eric Simon in
Google Scholar
PubMed Close
,
Martin Wagner Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm University, Ulm, Germany

Search for other papers by Martin Wagner in
Google Scholar
PubMed Close
,
Rajkumar Dorajoo Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

Search for other papers by Rajkumar Dorajoo in
Google Scholar
PubMed Close
,
Bernhard O Boehm Lee Kong Chiang School of Medicine, Nanyang Technological University, Singapore, Singapore
Imperial College London, London, UK

Search for other papers by Bernhard O Boehm in
Google Scholar
PubMed Close
,
Leticia Labriola Institute of Physiological Chemistry, Ulm University, Ulm, Germany
Department of Biochemistry, University of São Paulo, São Paulo, Brazil

Search for other papers by Leticia Labriola in
Google Scholar
PubMed Close
,
Thomas Wirth Institute of Physiological Chemistry, Ulm University, Ulm, Germany

Search for other papers by Thomas Wirth in
Google Scholar
PubMed Close
, and
Bernd Baumann Institute of Physiological Chemistry, Ulm University, Ulm, Germany

Search for other papers by Bernd Baumann in
Google Scholar
PubMed Close

Introduction Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous form of diabetes that is inherited in an autosomal-dominant pattern and in general, affected families have a history of diabetes over several generations

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0208
Volume/Issue:
Volume 244: Issue 2
Open access
Haijiang Wu Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

Search for other papers by Haijiang Wu in
Google Scholar
PubMed Close
,
Xinna Deng Departments of Oncology & Immunotherapy, Hebei General Hospital, Shijiazhuang, China

Search for other papers by Xinna Deng in
Google Scholar
PubMed Close
,
Yonghong Shi Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

Search for other papers by Yonghong Shi in
Google Scholar
PubMed Close
,
Ye Su Mathew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
Departments of Medicine and Pathology, University of Western Ontario, London, Ontario, Canada

Search for other papers by Ye Su in
Google Scholar
PubMed Close
,
Jinying Wei Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

Search for other papers by Jinying Wei in
Google Scholar
PubMed Close
, and
Huijun Duan Department of Pathology, Hebei Medical University, Shijiazhuang, China
Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China

Search for other papers by Huijun Duan in
Google Scholar
PubMed Close

Introduction Type 2 diabetes mellitus (T2DM) is a chronic metabolic isorder characterized by hyperglycemia in the context of insulin resistance (IR) and insulin secretion deficiency due to β-cell dysfunction. The global prevalence of T2DM is

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0021
Volume/Issue:
Volume 229: Issue 3
Free access
Sheree D Martin Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Australia

Search for other papers by Sheree D Martin in
Google Scholar
PubMed Close
and
Sean L McGee Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Australia

Search for other papers by Sean L McGee in
Google Scholar
PubMed Close

2 diabetes, cardiovascular disease and cancer ( Eyre et al . 2004 ). While common molecular mechanisms are only just beginning to emerge, there has been a wealth of epidemiological data describing the overlap between many of the diseases. Among this

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0037
Volume/Issue:
Volume 237: Issue 2
Free access