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S E Ulbrich Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Rehfeld Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Bauersachs Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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E Wolf Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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R Rottmayer Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Hiendleder Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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M Vermehren Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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F Sinowatz Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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H H D Meyer Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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R Einspanier Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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frequency and amplitude of motility around oestrus ( Bennett et al. 1988 ). Therefore, several mediators of contraction could be involved in this regulation, influencing or orchestrating the NOS expression in the oviduct, namely, oestradiol, oxytocin

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A Glover Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand

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S J Assinder Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand

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, Boer GJ & Pickering BT 1991 Testicular oxytocin: effects of intratesticular oxytocin in the rat. Journal of Endocrinology 130 231 –238. Ohkawa H , Ohishi N & Yagi K 1979 Assay for lipid peroxides in animal tissues by

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George Fink Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, Genetics Lane, Parkville, Victoria 3010, Australia

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anterior pituitary hormones as well as the regulation of the neurohypophysial hormones vasopressin and oxytocin. In this Thematic Review, I outline some aspects of the neurohumoral control of anterior pituitary (adenohypophysial) hormone secretion

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Darryl L Hadsell Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Walter Olea Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Nicole Lawrence Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Jessy George Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Daniel Torres Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Takahashi Kadowaki Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Adrian V Lee Department of Pediatrics,
Department of Molecular and Cellular Biology,
Department of Medicine, The Breast Center, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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weight gain on the Irs null dams, milk samples and mammary tissue were collected on day 10 post partum . Both the amount of milk recovered after oxytocin injection, and the wet weights of the number 4 mammary glands were significantly lower ( P < 0

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Andrés Quintanar-Stephano
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Roberto Chavira-Ramírez
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Kalman Kovacs
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Istvan Berczi
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. 1996 ). In rats with PSC, VP and oxytocin are transported via the newly formed neurohumoral connections from the remnants of the neural lobe axons to the long portal vessels ( Makara et al. 1995 , 1996 ). We have found that humoral (agglutinin

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Seymour Reichlin Professor of Medicine, Emeritus, Tufts University, Boston, Massachusetts, USA

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pituitary . Journal of the American Chemical Society 75 4880 – 4881 . ( doi:10.1021/ja01115a554 ) Du Vignaud V Ressier C Trippett S 1953b The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin . Journal of

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Kok-Min Seow Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Jyun-Lin Lee Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Ming-Luen Doong Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Seng-Wong Huang Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Jiann-Loung Hwang Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Wei-Ju Huang Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Full-Young Chang Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Low-Tone Ho Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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Chi-Chang Juan Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Institute of Physiology, Department of Surgery, Department of Obstetrics and Gynecology, Department of Nursing, Division of Gastroenterology, Department of Internal Medicine, Department of Education and Medical Research, Department of Education and Research, Shin Kong Wu Ho‐Su Memorial Hospital, Taipei, Taiwan

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gastrointestinal motility by estradiol in ovariectomized rats . Scandinavian Journal of Gastroenterology 37 1133 – 1139 . ( doi:10.1080/003655202760373326 ) Wu CL Hung CR Chang FY Pau KY Wang PS 2003 Pharmacological effects of oxytocin on gastric

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Madhusmita Misra BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Anne Klibanski BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Oxytocin is now known to have anorexigenic and bone anabolic effects ( Tamma et al . 2009 ), and oxytocin levels are lower in women with AN than controls and are associated with lower BMD ( Lawson et al . 2011 b ). Fig. 6 summarizes the various hormonal

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Hiroshi Nagano Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, Gifu, Japan

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Yuki Sobue Laboratory of Veterinary Pharmacology, Faculty of Applied Biological Science, Gifu University, Gifu, Japan

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Hayato Matsuyama Laboratory of Veterinary Pharmacology, Faculty of Applied Biological Science, Gifu University, Gifu, Japan

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Shoichiro Saito Laboratory of Veterinary Anatomy, Faculty of Applied Biological Science, Gifu University, Gifu, Japan

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Hiroki Sakai Laboratory of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, Gifu, Japan

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Firoj Alom Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, Gifu, Japan

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Yasuyuki Tanahashi Department of Animal Medical Sciences, Faculty of Life Science, Kyoto Sangyo University, Kyoto, Japan

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Toshiaki Ishii Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

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Toshihiro Unno Laboratory of Veterinary Pharmacology, Faculty of Applied Biological Science, Gifu University, Gifu, Japan

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CM Monesi N de Oliveira-Pelegrin GR Passos GA Rocha MJA 2007 Time course of c-fos, vasopressin and oxytocin mRNA expression in the hypothalamus following long-term dehydration . Cellular and Molecular Neurobiology 27 575 – 584 . ( https

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T V Novoselova Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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R Larder University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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D Rimmington University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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C Lelliott Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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E H Wynn Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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R J Gorrigan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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P H Tate Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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L Guasti Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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The Sanger Mouse Genetics Project Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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S O’Rahilly University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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A J L Clark Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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D W Logan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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A P Coll University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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L F Chan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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found that Sim1 mRNA level in the PVN of Mrap2 tm1a/tm1a mice was less than 50% of that observed in wild-type littermates ( Fig. 5C ). Sim1 is responsible for the late stages of the differentiation of oxytocin (Oxt), arginine vasopressin (Avp

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