Search Results
Search for other papers by C Suarez in
Google Scholar
PubMed
Search for other papers by I Garcia Tornadu in
Google Scholar
PubMed
Search for other papers by W Khalil in
Google Scholar
PubMed
Search for other papers by D Becu-Villalobos in
Google Scholar
PubMed
The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim of the present study was to determine the role of DHEA in diethylstilboestrol (DES)-induced pituitary hyperplasia. Female Sprague-Dawley rats were divided into four treatment groups: DES (implanted s.c. with a 20 mg DES pellet), DHEA (two 50 mg DHEA pellets), DHEA/DES (both DHEA and DES pellets), and controls (not implanted). Every week, all rats were weighed and cycled, and jugular blood samples were obtained. After 7 weeks, rats were killed. Hypophyses were removed and weighed, and serum prolactin, GH, IGF-I and leptin levels were assayed by RIA. DHEA cotreatment reduced pituitary enlargement by 39% in DES-treated rats. It also reduced the hyperprolactinaemia (280.4+/-43.6 ng/ml for DHEA/DES vs 823.5+/- 127.1 ng/ml for DES) and partially reversed the loss of body weight induced by DES. DHEA treatment did not modify the effects of DES on serum GH, IGF-I and leptin levels. But DHEA per se also increased pituitary weight and induced hyperprolactinaemia, although to a lesser degree than DES. We conclude that DHEA administration has beneficial effects on oestrogen-induced pituitary hyperplasia and hyperprolactinaemia, but the fact that DHEA per se also induces diverse hormonal effects and a slight pituitary enlargement limits its use as a possible therapeutic drug.
Search for other papers by Iain R Thompson in
Google Scholar
PubMed
Search for other papers by Annisa N Chand in
Google Scholar
PubMed
Search for other papers by Kim C Jonas in
Google Scholar
PubMed
Search for other papers by Jacky M Burrin in
Google Scholar
PubMed
Search for other papers by Mark E Steinhelper in
Google Scholar
PubMed
Search for other papers by Caroline P Wheeler-Jones in
Google Scholar
PubMed
Search for other papers by Craig A McArdle in
Google Scholar
PubMed
Endocrine Signalling Group, Barts and the London School of Medicine and Dentistry, Department of Medicine, Cardiovascular and Inflammation Group, Laboratory for Integrated Neurosciences and Endocrinology, Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Endocrine Signalling Group, Barts and the London School of Medicine and Dentistry, Department of Medicine, Cardiovascular and Inflammation Group, Laboratory for Integrated Neurosciences and Endocrinology, Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
Search for other papers by Robert C Fowkes in
Google Scholar
PubMed
lethality ( Chusho et al . 2001 ), but investigation of their neuroendocrine tissues has not been reported. Early studies characterising the expression profile of CNP suggested that the CNS and anterior pituitary are rich sources of CNP ( Sudoh et al
Search for other papers by Saadia Basharat in
Google Scholar
PubMed
Search for other papers by Jennifer A Parker in
Google Scholar
PubMed
Search for other papers by Kevin G Murphy in
Google Scholar
PubMed
Search for other papers by Stephen R Bloom in
Google Scholar
PubMed
Search for other papers by Julia C Buckingham in
Google Scholar
PubMed
Search for other papers by Christopher D John in
Google Scholar
PubMed
sepsis in patients, allowing differentiation between patients with systemic inflammatory response syndrome and patients with sepsis ( Yousef et al . 2010 ). The hypothalamic–pituitary–adrenal (HPA) axis plays an important protective role in the body
Search for other papers by Dóra Zelena in
Google Scholar
PubMed
Search for other papers by Ágnes Domokos in
Google Scholar
PubMed
Search for other papers by Subodh Kumar Jain in
Google Scholar
PubMed
Search for other papers by Ryan Jankord in
Google Scholar
PubMed
Search for other papers by Ludmila Filaretova in
Google Scholar
PubMed
Introduction Maintaining homeostasis in a constantly changing environment is a fundamental process of life. Hans Selye, the father of the stress concept, defined the hypothalamic–pituitary–adrenocortical (HPA) axis as the major component required
Search for other papers by Belkis Gizem Uzturk in
Google Scholar
PubMed
Search for other papers by Shan-xue Jin in
Google Scholar
PubMed
Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology
Search for other papers by Beverly Rubin in
Google Scholar
PubMed
Search for other papers by Christopher Bartolome in
Google Scholar
PubMed
Sackler School of Graduate Biomedical Sciences, Departments of Developmental, Integrated Physiology and Pathobiology, Molecular and Chemical Biology
Search for other papers by Larry A Feig in
Google Scholar
PubMed
Introduction The hypothalamic–pituitary–adrenal (HPA) axis plays a vital role in restoring homeostasis following environmental challenge. Physical or psychological stress results in cortisol production in humans or corticosterone (CORT) in rodents
Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, Tennessee 38163, USA
Search for other papers by Michal A Zmijewski in
Google Scholar
PubMed
Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, Tennessee 38163, USA
Search for other papers by Rajesh K Sharma in
Google Scholar
PubMed
Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, Tennessee 38163, USA
Search for other papers by Andrzej T Slominski in
Google Scholar
PubMed
Introduction Corticotropin-releasing factor (CRF) is the most proximal element of the hypothalamic–pituitary–adrenal (HPA) axis, a system that coordinates the body response to systemic stress ( Selye 1936 , Vale et al. 1981
Search for other papers by Francesca Spiga in
Google Scholar
PubMed
Search for other papers by Louise R Harrison in
Google Scholar
PubMed
Search for other papers by Susan Wood in
Google Scholar
PubMed
Search for other papers by David M Knight in
Google Scholar
PubMed
Search for other papers by Cliona P MacSweeney in
Google Scholar
PubMed
Search for other papers by Fiona Thomson in
Google Scholar
PubMed
Search for other papers by Mark Craighead in
Google Scholar
PubMed
Search for other papers by Stafford L Lightman in
Google Scholar
PubMed
Introduction Vasopressin (arginine vasopressin, AVP) and CRH are the two main neuropeptides regulating the hypothalamic–pituitary–adrenal (HPA) axis. AVP is a nonapeptide synthesised in parvocellular neurons of the paraventricular nucleus (PVN) of
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
Search for other papers by Nathalie Marissal-Arvy in
Google Scholar
PubMed
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
Search for other papers by Rachel Hamiani in
Google Scholar
PubMed
Search for other papers by Emmanuel Richard in
Google Scholar
PubMed
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
Search for other papers by Marie-Pierre Moisan in
Google Scholar
PubMed
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
Search for other papers by Véronique Pallet in
Google Scholar
PubMed
brain-derived neurotrophic factor ( Brossaud et al . 2013 ), only a few studies have explored the regulation of hypothalamic–pituitary–adrenal (HPA) axis function by retinoids. Previous studies have suggested an inhibition of glucocorticoid synthesis
Search for other papers by Ladan Eshkevari in
Google Scholar
PubMed
Search for other papers by Eva Permaul in
Google Scholar
PubMed
Search for other papers by Susan E Mulroney in
Google Scholar
PubMed
Introduction The classic response to chronic stress consists of an elegant, concerted interplay of two important pathways, the sympathetic nervous system (SNS) and the hypothalamus–pituitary–adrenal axis (HPA). The chronic activation of these stress
Search for other papers by Nathalie Marissal-Arvy in
Google Scholar
PubMed
Search for other papers by Alexandra Gaumont in
Google Scholar
PubMed
Search for other papers by Allan Langlois in
Google Scholar
PubMed
Search for other papers by Fabrice Dabertrand in
Google Scholar
PubMed
Search for other papers by Marion Bouchecareilh in
Google Scholar
PubMed
Search for other papers by Claudine Tridon in
Google Scholar
PubMed
Search for other papers by Pierre Mormede in
Google Scholar
PubMed
in animals ( Levin et al . 1997 ). A key process involved in this variability lies in the responsivity of the hypothalamic–pituitary–adrenocortical (HPA) axis. Indeed, corticosteroid hormones are implicated in nutritional regulations 1) by their
