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Wu Luo Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
Department of Endocrinology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Lan Huang Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Jingying Wang Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Fei Zhuang Department of Endocrinology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Zheng Xu Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Haimin Yin Department of Endocrinology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Yuanyuan Qian Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Guang Liang Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Chao Zheng Department of Endocrinology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

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Yi Wang Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China

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interstitial and perivascular fibrosis, ventricular hypertrophy, as well as diastolic and systolic dysfunction, all occurring in the absence of coronary artery disease and hypertension ( Bugger & Abel 2014 ). The underlying factors driving the development of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0058
Volume/Issue:
Volume 242: Issue 3
Free access
Shaodong Guo Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M University Health Science Center, Scott & White, Central Texas Veterans Health Care System, 1901 South 1st Street, Bldg. 205, Temple, Texas 76504, USA

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) transcription factor, a family member of the SREBPs that promote lipid and cholesterol synthesis ( Yecies et al . 2011 ). Moreover, mTORC2 and PDK1 suppress the Foxo1 forkhead transcription factor that promotes gluconeogenesis, mediating the effect of insulin

Article Type:
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DOI:
https://doi.org/10.1530/JOE-13-0327
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Volume 220: Issue 2
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Kazunori Kageyama
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Komaki Hanada
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Yasumasa Iwasaki Department of Endocrinology and Metabolism, Department of Endocrinology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan

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Toshihiro Suda
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corticotropin-releasing factor, vasopressin and interleukin-6 gene transcription in hypothalamic 4B cells . Journal of Endocrinology 195 199 – 211 . Karalis K Muglia LJ Bae D Hilderbrand JA 1997 CRH and the immune system . Journal of

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https://doi.org/10.1677/JOE-08-0506
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Volume 201: Issue 3
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A Fratticci Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F A Grieco Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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C Spilioti Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F Giangaspero Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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L Ventura Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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V Esposito Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M Piccirilli Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Santoro Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Gulino Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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G Cantore Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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E Alesse Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M L Jaffrain-Rea Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0020
Volume/Issue:
Volume 194: Issue 3
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Stefanie Ruhs Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Alexander Nolze Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Ralf Hübschmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Claudia Grossmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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( Fig. 1 ). Figure 1 Aldosterone/MR signaling. Aldosterone (aldo) has several mechanisms of action. (1) It can bind to cytosolic MR and initiate translocation of MR into the nucleus, where the MR homodimerizes and acts as a transcription factor

Article Type:
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DOI:
https://doi.org/10.1530/JOE-16-0659
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Volume 234: Issue 1
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Susanne Granholm Department of Oral Cell Biology, Umeå University, S-901 87 Umeå, Sweden

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Pernilla Lundberg Department of Oral Cell Biology, Umeå University, S-901 87 Umeå, Sweden

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Ulf H Lerner Department of Oral Cell Biology, Umeå University, S-901 87 Umeå, Sweden

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quantitative real-time PCR analyses of c-Fms (B) and RANK (C) at 24–96 h are shown. In (D), the semi-quantitative RT-PCR analyses of the mRNA expression of the transcription factors c-Fos, c-Jun, NFAT-2 and the mRNA expression of IκBα, the inhibitory component

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https://doi.org/10.1677/JOE-07-0338
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Volume 195: Issue 3
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Dae Ryong Cha
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Young Sun Kang
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Sang Youb Han
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Yi Hwa Jee
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Kum Hyun Han
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Jee Young Han
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Young Sik Kim
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Nan Hee Kim
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Introduction Diabetic nephropathy is one of the most serious micro-vascular complications. The diabetic milieu results in the increased expression of angiogenic growth factors in numerous tissues in response to both hyperglycemia and

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https://doi.org/10.1677/joe.1.05647
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Volume 183: Issue 1
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Esther Dos Santos Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Noëlle Dieudonné Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Christine Leneveu Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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René Pecquery Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Valérie Serazin Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Yves Giudicelli Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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the phospholipase A2 in the cytoplasm and several transcription factors in the nucleus like the proto-oncogene c-fos ( Janknecht et al. 1995 ), which plays a pivotal role in preadipocyte growth induction ( Lacasa et al. 1997 a , b ). The

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https://doi.org/10.1677/JOE-06-0101
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Volume 194: Issue 2
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Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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transcription factors to regulate gene expression and composite binding in which GC/GR requires both GRE elements and physical interaction with other transcription factors to exert its transcriptional activity. BTM: basal transcription machinery. Once

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https://doi.org/10.1530/JOE-20-0173
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Volume 247: Issue 3
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Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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controlled activation/repression of specific transcription factors and downstream gene clusters in a time-dependent manner. These complex signalling events drive the transition from definitive endoderm cells to mature insulin-secreting β-cells with the

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Review Article
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https://doi.org/10.1530/JOE-17-0516
Volume/Issue:
Volume 236: Issue 2
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