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2 diabetes, cardiovascular disease and cancer ( Eyre et al . 2004 ). While common molecular mechanisms are only just beginning to emerge, there has been a wealth of epidemiological data describing the overlap between many of the diseases. Among this
Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Pathobiology, The University of Tennessee, 1215 W. Cumberland Avenue, JHB 229, Knoxville, Tennessee 37996-1920, USA
The Jackson Laboratory, Bar Harbor, Maine, USA
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Introduction The prevalence of diabetes is growing worldwide and it is estimated that 366 million people will be affected by the year 2030 (171 million in the year 2000; Wild et al. 2004 ). Diabetes is associated with an increased
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College of Health and Biomedicine, School of Biomedical Sciences, Biosciences Research Precinct, School of Pharmacy, Victoria University, St Albans, Victoria 3021, Australia
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College of Health and Biomedicine, School of Biomedical Sciences, Biosciences Research Precinct, School of Pharmacy, Victoria University, St Albans, Victoria 3021, Australia
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College of Health and Biomedicine, School of Biomedical Sciences, Biosciences Research Precinct, School of Pharmacy, Victoria University, St Albans, Victoria 3021, Australia
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most devastating acquired vascular complications of diabetes mellitus, is responsible for affecting overall life quality worldwide. It has been estimated that the number of Americans suffering from DR will be 16 million by 2050 ( Milne & Brownstein 2013
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Introduction The population with type 2 diabetes mellitus and metabolic syndrome has been increasing worldwide and diabetic nephropathy is a leading cause in many countries, requiring renal replacement therapy. Obesity and insulin
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Introduction The current worldwide obesity epidemic drives an increased incidence and prevalence of gestational diabetes mellitus (GDM) as well as type 2 diabetes (T2D) in pregnancy ( Sun et al. 2022 ). In 2019, according to the
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( Cypess et al. 2009 , van Marken Lichtenbelt et al. 2009 ). More recent analysis of large datasets support the protective effects of 18 F-FDG uptake by human BAT at room temperature against developing type 2 diabetes mellitus (T2DM), hypertension and
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. Diabetes 46 2119 – 2123 . ( doi:10.2337/diabetes.46.12.2119 ) Schwartz MW Woods SC Porte D Jr Seeley RJ Baskin DG 2000 Central nervous system control of food intake . Nature 404 661 – 671 . Smajilovic S Clemmensen C Johansen
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Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK
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Hubrecht Institute, Utrecht, the Netherlands
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Introduction Phenotypic plasticity of fully differentiated cells in adult pancreatic islets has been demonstrated in several rodent models of diabetes in vivo ( Thorel et al. 2010 , Talchai et al. 2012 , Brereton et al. 2014 , Piran
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Ralph H. Johnson Veterans Affairs Medical Center, Division of Endocrinology, Charleston, South Carolina 29401, USA
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Ralph H. Johnson Veterans Affairs Medical Center, Division of Endocrinology, Charleston, South Carolina 29401, USA
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Introduction Epidemiological studies have consistently shown that patients with diabetes mellitus have increased mortality and morbidity of cardiovascular disease compared with the general population ( Soedamah-Muthu & Stehouwer 2005 ). To determine
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Introduction Type 1 (insulin-dependent) diabetes is a chronic disease affecting genetically predisposed individuals, in which insulin-secreting β-cells within pancreatic islets of Langerhans are selectively and irreversibly destroyed