Search Results

You are looking at 111 - 120 of 1,875 items for :

  • transcriptional activity x
  • Refine by Access: Content accessible to me x
Clear All
Free access

Michal A Zmijewski, Rajesh K Sharma, and Andrzej T Slominski

epidermal keratinocytes ( Zbytek & Slominski 2005 , Slominski et al. 2006 a ) and squamous cell carcinoma ( Kiang 1995 ). We also studied transcriptional activity of CRE and AP1 responsive elements and of human POMC promoter (−771 to −8) in

Restricted access

Yan Cao, Zijie Feng, Xin He, Xuyao Zhang, Bowen Xing, Yuan Wu, Taylor Hojnacki, Bryson W Katona, Jian Ma, Xiaorong Zhan, and Xianxin Hua

(JAK2)-signal transducer and activator of transcription 5 (STAT5), phosphatidylinositol 3-kinase (PI3K)-AKT, and MAPK-extracellular regulated protein kinase (ERK) pathways ( Amaral et al. 2004 , Brelje et al. 2004 , Rieck et al. 2009

Free access

Vicki E Smith, Jayne A Franklyn, and Christopher J McCabe

promoter activity and PTTG had only a limited effect. However, co-expression of PTTG and PBF induced activity more than threefold, indicating that PBF is required for PTTG to transactivate FGF-2 ( Chien & Pei 2000 ). PBF may, therefore, mediate the

Free access

Chad D Osterlund, Vanessa Thompson, Laura Hinds, and Robert L Spencer

the rat PVN ( Luo et al . 1995 ). Thus, the long-term absence of CORT may lead to an augmented positive CRH feedback loop onto PVN CRH neurons, resulting in increased signaling activity (e.g., MAP-kinase activation), transcriptional processes (e

Free access

O A Sukocheva and D O Carpenter

phosphorylation of the nuclear THs receptor (TR) and transcriptional activity ( Yen 2001 , Davis & Davis 2002 , Shih et al. 2004 ). THs may also exert a fast permissive action on the target cells’ responsiveness to other active peptide and hormones

Free access

L Bouraoui, J Gutiérrez, and I Navarro

(PPARγ) have been identified as transcriptional factors ( MacDougald & Lane 1995 ) and are necessary for the transition of pre-adipocytes into adipocytes in vitro . In mammals, insulin growth factor-I (IGF-I) affects adipocyte proliferation and

Restricted access

Anne-Marie Neumann, Cathleen Geißler, Violetta Pilorz, Iwona Olejniczak, Alfor G Lewis, Randy J Seeley, Orr Shomroni, Gabriela Salinas-Riester, Henriette Kirchner, and Henrik Oster

environment. Major SCN outputs include locomotor activity, body temperature and feeding ( Begemann et al. 2020 ). Peripheral circadian clocks are synchronized by the SCN to regulate tissue physiology via transcriptional programs. Unlike the SCN, many

Free access

Giuseppe Calamita, Maria Moreno, Domenico Ferri, Elena Silvestri, Patrizia Roberti, Luigi Schiavo, Patrizia Gena, Maria Svelto, and Fernando Goglia

to thyroid hormone administration or to physiological states modulating thyroid gland activity (e.g. cold exposure, aging, dietary changes; Goglia et al. 1999 ). Indeed, alterations to the thyroid state of animals have considerable effects on the

Free access

Barry N Madison, Patrick T K Woo, and Nicholas J Bernier

). Parasite infection was also associated with multiple changes in transcriptional activity in the interrenal cells of the head kidney. Relative to those in the control fish, while the mRNA levels of mc2r in the infected fish were increased by 2.8-fold at 4

Free access

Xiaojiong Du, Sirong He, Yaowen Jiang, Lingling Wei, and Weiming Hu

( Yang et al . 2001 , Elias-Miro et al . 2011 ). A number of reports suggest that the beneficial vascular and anti-inflammatory activity of adiponectin might contribute to its therapeutic potential during ischemia–reperfusion injury ( Goldstein et al